Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides
Background: Brain tumors are the second most common neoplasm in the pediatric age. Pesticides may play an etiologic role, but literature results are conflicting. This review provides a systematic overview, meta-analysis, and IARC/WHO consideration of data on parental exposure to pesticides and child...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/12/1096 |
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| author | Joseph Feulefack Aiza Khan Francesco Forastiere Consolato M. Sergi |
| author_facet | Joseph Feulefack Aiza Khan Francesco Forastiere Consolato M. Sergi |
| author_sort | Joseph Feulefack |
| collection | DOAJ |
| description | Background: Brain tumors are the second most common neoplasm in the pediatric age. Pesticides may play an etiologic role, but literature results are conflicting. This review provides a systematic overview, meta-analysis, and IARC/WHO consideration of data on parental exposure to pesticides and childhood brain tumors. Methods: We searched PubMed, SCOPUS, and Google Scholar for literature (1 January 1966–31 December 2020) that assessed childhood brain tumors and parental exposure to pesticides. We undertook a meta-analysis addressing prenatal exposure, exposure after birth, occupational exposure, and residential exposure. A total of 130 case-control investigations involving 43,598 individuals (18,198 cases and 25,400 controls) were included. Results: Prenatal exposure is associated with childhood brain tumors (odds ratio, OR = 1.32; 95% CI: 1.17–1.49; I<sup>2</sup> = 41.1%). The same occurs after birth exposure (OR = 1.22; 95% CI: 1.03–1.45, I<sup>2</sup> = 72.3%) and residential exposure to pesticides (OR = 1.31; 95% CI: 1.11–1.54, I<sup>2</sup> = 67.2%). Parental occupational exposure is only marginally associated with CBT (OR = 1.17, 95% CI: 0.99–1.38, I<sup>2</sup> = 67.0%). Conclusions: There is an association between CBT and parental pesticides exposure before childbirth, after birth, and residential exposure. It is in line with the IARC Monograph evaluating the carcinogenicity of diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. |
| first_indexed | 2024-03-10T04:24:46Z |
| format | Article |
| id | doaj.art-6628c496e68a425a81bd1623ee80045c |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T04:24:46Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-6628c496e68a425a81bd1623ee80045c2023-11-23T07:41:54ZengMDPI AGChildren2227-90672021-11-01812109610.3390/children8121096Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and HerbicidesJoseph Feulefack0Aiza Khan1Francesco Forastiere2Consolato M. Sergi3National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, ChinaDepartment of Lab. Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, CanadaDepartment of Epidemiology, Regional Health Service of Lazio, 00147 Rome, ItalyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, ChinaBackground: Brain tumors are the second most common neoplasm in the pediatric age. Pesticides may play an etiologic role, but literature results are conflicting. This review provides a systematic overview, meta-analysis, and IARC/WHO consideration of data on parental exposure to pesticides and childhood brain tumors. Methods: We searched PubMed, SCOPUS, and Google Scholar for literature (1 January 1966–31 December 2020) that assessed childhood brain tumors and parental exposure to pesticides. We undertook a meta-analysis addressing prenatal exposure, exposure after birth, occupational exposure, and residential exposure. A total of 130 case-control investigations involving 43,598 individuals (18,198 cases and 25,400 controls) were included. Results: Prenatal exposure is associated with childhood brain tumors (odds ratio, OR = 1.32; 95% CI: 1.17–1.49; I<sup>2</sup> = 41.1%). The same occurs after birth exposure (OR = 1.22; 95% CI: 1.03–1.45, I<sup>2</sup> = 72.3%) and residential exposure to pesticides (OR = 1.31; 95% CI: 1.11–1.54, I<sup>2</sup> = 67.2%). Parental occupational exposure is only marginally associated with CBT (OR = 1.17, 95% CI: 0.99–1.38, I<sup>2</sup> = 67.0%). Conclusions: There is an association between CBT and parental pesticides exposure before childbirth, after birth, and residential exposure. It is in line with the IARC Monograph evaluating the carcinogenicity of diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos.https://www.mdpi.com/2227-9067/8/12/1096childrencancerbrainepidemiologycarcinogenicitydiazinon |
| spellingShingle | Joseph Feulefack Aiza Khan Francesco Forastiere Consolato M. Sergi Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides Children children cancer brain epidemiology carcinogenicity diazinon |
| title | Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides |
| title_full | Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides |
| title_fullStr | Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides |
| title_full_unstemmed | Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides |
| title_short | Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides |
| title_sort | parental pesticide exposure and childhood brain cancer a systematic review and meta analysis confirming the iarc who monographs on some organophosphate insecticides and herbicides |
| topic | children cancer brain epidemiology carcinogenicity diazinon |
| url | https://www.mdpi.com/2227-9067/8/12/1096 |
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