Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma
Objective To evaluate the role of the log odds of positive lymph nodes (LODDS) in predicting the long-term prognosis of patients with thoracic esophageal squamous cell carcinoma (TESCC). Methods We retrospectively analyzed the clinical data of 731 TESCC patients after radical surgery and the prognos...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2020-03-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.0417.htm |
| _version_ | 1828193415286751232 |
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| author | GAO Hongmei CHI Shuping SHEN Wenbin |
| author_facet | GAO Hongmei CHI Shuping SHEN Wenbin |
| author_sort | GAO Hongmei |
| collection | DOAJ |
| description | Objective To evaluate the role of the log odds of positive lymph nodes (LODDS) in predicting the long-term prognosis of patients with thoracic esophageal squamous cell carcinoma (TESCC). Methods We retrospectively analyzed the clinical data of 731 TESCC patients after radical surgery and the prognostic value of LODDS in the whole group of patients, postoperative lymph node-negative (pN0) patients and patients with the number of intraoperative lymph nodes dissected < 12. Results LODDS was significantly correlated with the number of positive lymph nodes and the number of intraoperative lymph nodes dissected (r=0.696, -0.530, all P=0.000). ROC curve analysis showed that the optimal cut-off point of LODDS was -1.028. Multivariate analysis showed that gender, age, location of esophageal lesions, pT stage, number of positive lymph nodes and LODDS value were independent factors for the survival of the whole group and the OS of the patients with the number of intraoperative lymph nodes dissected≥12 (P < 0.05). Gender, age, location of esophageal lesions, pT stage and LODDS value were independent factors affecting the survival of pN0 patients after operation (P < 0.05). pT stage and LODDS value were independent factors affecting the OS of the patients with the number of intraoperative lymph nodes dissected < 12 (P < 0.05). Conclusion LODDS could be used as an independent prognostic index for the patients with different TESCC after radical surgery. |
| first_indexed | 2024-04-12T09:07:08Z |
| format | Article |
| id | doaj.art-662b256c8ccb4b4ca581ad64c6a98bb0 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-04-12T09:07:08Z |
| publishDate | 2020-03-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-662b256c8ccb4b4ca581ad64c6a98bb02022-12-22T03:39:03ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-03-0147318518910.3971/j.issn.1000-8578.2020.19.04178578.2020.19.0417Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell CarcinomaGAO Hongmei0CHI Shuping1SHEN Wenbin2Department of Radiology, Shijiazhuang First Hospital, Shijiazhuang 050011, ChinaDepartment of Radiology, Shijiazhuang First Hospital, Shijiazhuang 050011, ChinaDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaObjective To evaluate the role of the log odds of positive lymph nodes (LODDS) in predicting the long-term prognosis of patients with thoracic esophageal squamous cell carcinoma (TESCC). Methods We retrospectively analyzed the clinical data of 731 TESCC patients after radical surgery and the prognostic value of LODDS in the whole group of patients, postoperative lymph node-negative (pN0) patients and patients with the number of intraoperative lymph nodes dissected < 12. Results LODDS was significantly correlated with the number of positive lymph nodes and the number of intraoperative lymph nodes dissected (r=0.696, -0.530, all P=0.000). ROC curve analysis showed that the optimal cut-off point of LODDS was -1.028. Multivariate analysis showed that gender, age, location of esophageal lesions, pT stage, number of positive lymph nodes and LODDS value were independent factors for the survival of the whole group and the OS of the patients with the number of intraoperative lymph nodes dissected≥12 (P < 0.05). Gender, age, location of esophageal lesions, pT stage and LODDS value were independent factors affecting the survival of pN0 patients after operation (P < 0.05). pT stage and LODDS value were independent factors affecting the OS of the patients with the number of intraoperative lymph nodes dissected < 12 (P < 0.05). Conclusion LODDS could be used as an independent prognostic index for the patients with different TESCC after radical surgery.http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.0417.htmesophageal neoplasms/esophageal squamous cell carcinomaradical surgicallog odds of positive lymph nodes(lodds)prognosis |
| spellingShingle | GAO Hongmei CHI Shuping SHEN Wenbin Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma Zhongliu Fangzhi Yanjiu esophageal neoplasms/esophageal squamous cell carcinoma radical surgical log odds of positive lymph nodes(lodds) prognosis |
| title | Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma |
| title_full | Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma |
| title_fullStr | Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma |
| title_full_unstemmed | Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma |
| title_short | Role of Log Odds of Positive Lymph Nodes in Predicting Long-term Prognosis of Patients with Thoracic Esophageal Squamous Cell Carcinoma |
| title_sort | role of log odds of positive lymph nodes in predicting long term prognosis of patients with thoracic esophageal squamous cell carcinoma |
| topic | esophageal neoplasms/esophageal squamous cell carcinoma radical surgical log odds of positive lymph nodes(lodds) prognosis |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.0417.htm |
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