Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.
<h4>Background</h4>Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB tre...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227472&type=printable |
| _version_ | 1826574272828538880 |
|---|---|
| author | Paulo Ruiz-Grosso Rodrigo Cachay Adriana de la Flor Alvaro Schwalb Cesar Ugarte-Gil |
| author_facet | Paulo Ruiz-Grosso Rodrigo Cachay Adriana de la Flor Alvaro Schwalb Cesar Ugarte-Gil |
| author_sort | Paulo Ruiz-Grosso |
| collection | DOAJ |
| description | <h4>Background</h4>Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment.<h4>Methods</h4>We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019.<h4>Results</h4>Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33-7.79; I2 = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50-11.64; I2 = 0%) and death (OR = 2.85; CI95%:1.52-5.36; I2 = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70-2.72; I2 = 94.36) or PD alone (OR = 0.92; CI95%:0.81-1.05; I2 = 0%).<h4>Conclusions</h4>DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic. |
| first_indexed | 2024-12-22T12:38:39Z |
| format | Article |
| id | doaj.art-662c50be0ee54bce92e86ec940024ece |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T12:56:10Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-662c50be0ee54bce92e86ec940024ece2025-03-02T05:33:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022747210.1371/journal.pone.0227472Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.Paulo Ruiz-GrossoRodrigo CachayAdriana de la FlorAlvaro SchwalbCesar Ugarte-Gil<h4>Background</h4>Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment.<h4>Methods</h4>We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019.<h4>Results</h4>Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33-7.79; I2 = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50-11.64; I2 = 0%) and death (OR = 2.85; CI95%:1.52-5.36; I2 = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70-2.72; I2 = 94.36) or PD alone (OR = 0.92; CI95%:0.81-1.05; I2 = 0%).<h4>Conclusions</h4>DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227472&type=printable |
| spellingShingle | Paulo Ruiz-Grosso Rodrigo Cachay Adriana de la Flor Alvaro Schwalb Cesar Ugarte-Gil Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. PLoS ONE |
| title | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. |
| title_full | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. |
| title_fullStr | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. |
| title_full_unstemmed | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. |
| title_short | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. |
| title_sort | association between tuberculosis and depression on negative outcomes of tuberculosis treatment a systematic review and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227472&type=printable |
| work_keys_str_mv | AT pauloruizgrosso associationbetweentuberculosisanddepressiononnegativeoutcomesoftuberculosistreatmentasystematicreviewandmetaanalysis AT rodrigocachay associationbetweentuberculosisanddepressiononnegativeoutcomesoftuberculosistreatmentasystematicreviewandmetaanalysis AT adrianadelaflor associationbetweentuberculosisanddepressiononnegativeoutcomesoftuberculosistreatmentasystematicreviewandmetaanalysis AT alvaroschwalb associationbetweentuberculosisanddepressiononnegativeoutcomesoftuberculosistreatmentasystematicreviewandmetaanalysis AT cesarugartegil associationbetweentuberculosisanddepressiononnegativeoutcomesoftuberculosistreatmentasystematicreviewandmetaanalysis |