The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review
Bladder cancer (BCa) is a common type of cancer that affects the urinary bladder. The early detection and management of BCa is critical for successful treatment and patient outcomes. In recent years, researchers have been exploring the use of biomarkers as a non-invasive and effective tool for the d...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/19/3119 |
| _version_ | 1827722627374907392 |
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| author | Luca Di Gianfrancesco Alessandro Crestani Antonio Amodeo Paolo Corsi Davide De Marchi Eugenio Miglioranza Giuliana Lista Francesca Simonetti Gian Maria Busetto Martina Maggi Francesco Pierconti Maurizio Martini Isabella Monia Montagner Debora Tormen Antonio Scapinello Filippo Marino Angelo Porreca |
| author_facet | Luca Di Gianfrancesco Alessandro Crestani Antonio Amodeo Paolo Corsi Davide De Marchi Eugenio Miglioranza Giuliana Lista Francesca Simonetti Gian Maria Busetto Martina Maggi Francesco Pierconti Maurizio Martini Isabella Monia Montagner Debora Tormen Antonio Scapinello Filippo Marino Angelo Porreca |
| author_sort | Luca Di Gianfrancesco |
| collection | DOAJ |
| description | Bladder cancer (BCa) is a common type of cancer that affects the urinary bladder. The early detection and management of BCa is critical for successful treatment and patient outcomes. In recent years, researchers have been exploring the use of biomarkers as a non-invasive and effective tool for the detection and monitoring of BCa. One such biomarker is programmed death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells and plays a crucial role in the evasion of the immune system. Studies have shown that the PD-L1 expression is higher in BCa tumors than in healthy bladder tissue. Additionally, PD-L1 expression might even be detected in urine samples in BCa patients, in addition to the examination of a histological sample. The technique is being standardized and optimized. We reported how BCa patients had higher urinary PD-L1 levels than controls by considering BCa tumors expressing PD-L1 in the tissue specimen. The expression of PD-L1 in urinary BCa cells might represent both a diagnostic and a prognostic tool, with the perspective that the PD-L1 expression of exfoliate urinary cells might reveal and anticipate eventual BCa recurrence or progression. Further prospective and longitudinal studies are needed to assess the expression of PD-L1 as a biomarker for the monitoring of BCa patients. The use of PD-L1 as a biomarker for the detection and monitoring of BCa has the potential to significantly improve patient outcomes by allowing for earlier detection and more effective management of the disease. |
| first_indexed | 2024-03-10T21:46:37Z |
| format | Article |
| id | doaj.art-662c8c7583fb4a5a9b10d95caf389d73 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T21:46:37Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-662c8c7583fb4a5a9b10d95caf389d732023-11-19T14:15:03ZengMDPI AGDiagnostics2075-44182023-10-011319311910.3390/diagnostics13193119The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative ReviewLuca Di Gianfrancesco0Alessandro Crestani1Antonio Amodeo2Paolo Corsi3Davide De Marchi4Eugenio Miglioranza5Giuliana Lista6Francesca Simonetti7Gian Maria Busetto8Martina Maggi9Francesco Pierconti10Maurizio Martini11Isabella Monia Montagner12Debora Tormen13Antonio Scapinello14Filippo Marino15Angelo Porreca16Department of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyDepartment of Urology, University of Foggia, 71122 Foggia, ItalyDepartment of Urology, Sapienza University, 00185 Rome, ItalyDepartment of Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, University of Sacred Heart, 00168 Rome, ItalyDepartment of Pathology, University of Messina, 98122 Messina, ItalyAnatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV—IRCCS, 35128 Padua, ItalyAnatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV—IRCCS, 35128 Padua, ItalyAnatomy and Pathological Histology Unit, Veneto Institute of Oncology IOV—IRCCS, 35128 Padua, ItalyDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, University of Sacred Heart, 00168 Rome, ItalyDepartment of Urology, Veneto Institute of Oncology (IOV)—IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, ItalyBladder cancer (BCa) is a common type of cancer that affects the urinary bladder. The early detection and management of BCa is critical for successful treatment and patient outcomes. In recent years, researchers have been exploring the use of biomarkers as a non-invasive and effective tool for the detection and monitoring of BCa. One such biomarker is programmed death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells and plays a crucial role in the evasion of the immune system. Studies have shown that the PD-L1 expression is higher in BCa tumors than in healthy bladder tissue. Additionally, PD-L1 expression might even be detected in urine samples in BCa patients, in addition to the examination of a histological sample. The technique is being standardized and optimized. We reported how BCa patients had higher urinary PD-L1 levels than controls by considering BCa tumors expressing PD-L1 in the tissue specimen. The expression of PD-L1 in urinary BCa cells might represent both a diagnostic and a prognostic tool, with the perspective that the PD-L1 expression of exfoliate urinary cells might reveal and anticipate eventual BCa recurrence or progression. Further prospective and longitudinal studies are needed to assess the expression of PD-L1 as a biomarker for the monitoring of BCa patients. The use of PD-L1 as a biomarker for the detection and monitoring of BCa has the potential to significantly improve patient outcomes by allowing for earlier detection and more effective management of the disease.https://www.mdpi.com/2075-4418/13/19/3119bladder cancerPD-L1urinary biomarkerdiagnostic toolprognostic tool |
| spellingShingle | Luca Di Gianfrancesco Alessandro Crestani Antonio Amodeo Paolo Corsi Davide De Marchi Eugenio Miglioranza Giuliana Lista Francesca Simonetti Gian Maria Busetto Martina Maggi Francesco Pierconti Maurizio Martini Isabella Monia Montagner Debora Tormen Antonio Scapinello Filippo Marino Angelo Porreca The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review Diagnostics bladder cancer PD-L1 urinary biomarker diagnostic tool prognostic tool |
| title | The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review |
| title_full | The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review |
| title_fullStr | The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review |
| title_full_unstemmed | The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review |
| title_short | The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer: A Narrative Review |
| title_sort | role of checkpoint inhibitor expression directly on exfoliated cells from bladder cancer a narrative review |
| topic | bladder cancer PD-L1 urinary biomarker diagnostic tool prognostic tool |
| url | https://www.mdpi.com/2075-4418/13/19/3119 |
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