Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

Abstract Background Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufalin is an active antitumour compound whose efficacy has been indicated b...

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Bibliographic Details
Main Authors: Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin, Ke Xu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Translational Medicine
Subjects:
Angiogenesis
Bufalin
Colorectal cancer
STAT3
Tumour microenvironment
Online Access:https://doi.org/10.1186/s12967-021-03058-z

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