Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Abstract Background Single-cell transcription data provided unprecedented molecular information, enabling us to directly encode the ecosystem of colorectal cancer (CRC). Characterization of the diversity of epithelial cells and how they cooperate with tumor microenvironment cells (TME) to endow CRC...

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Bibliographic Details
Main Authors: Rongfang Shen, Ping Li, Botao Zhang, Lin Feng, Shujun Cheng
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
scRNA-seq
Tumor heterogeneity
Epithelium-microenvironment communication
Tumor-associated macrophages
Cancer-associated fibroblasts
Online Access:https://doi.org/10.1186/s12967-022-03661-8

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