Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients
Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and al...
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| Format: | Article |
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Elsevier
2017-02-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664616302686 |
| _version_ | 1819029535037849600 |
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| author | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun |
| author_facet | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun |
| author_sort | Hung-Pin Lin |
| collection | DOAJ |
| description | Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs−/RAS) patients.
Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs−/RAS patients, and 342 healthy control subjects.
Results: GPCA+/RAS patients had significantly lower mean Hb and serum iron level (for women only) as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/RAS patients had a significantly higher MCV and a significantly greater frequency of vitamin B12 deficiency than Abs−/RAS patients. Furthermore, Abs−/RAS patients did have significantly lower mean Hb, MCV, iron, and folic acid levels and significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Of 31 GPCA+/RAS patients, 3 (9.7%) had PA, 6 (19.4%) had vitamin B12 deficiency, and 3 (9.7%) had macrocytosis. Moreover, normocytic anemia (54.0%) and iron deficiency anemia (26.4%) are the two more common types of anemia in our RAS patients.
Conclusions: We conclude that serum GPCA plays a significant role in causing vitamin B12 deficiency and high MCV in GPCA+/RAS patients. RAS itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA+/RAS and Abs−/RAS patients. |
| first_indexed | 2024-12-21T06:15:48Z |
| format | Article |
| id | doaj.art-662dcc0f43e547208465e1352a039bc5 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-21T06:15:48Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-662dcc0f43e547208465e1352a039bc52022-12-21T19:13:24ZengElsevierJournal of the Formosan Medical Association0929-66462017-02-0111629910610.1016/j.jfma.2016.10.006Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patientsHung-Pin Lin0Yu-Hsueh Wu1Yi-Ping Wang2Yang-Che Wu3Julia Yu-Fong Chang4Andy Sun5Department of Dentistry, MacKay Memorial Hospital, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanApproximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs−/RAS) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs−/RAS patients, and 342 healthy control subjects. Results: GPCA+/RAS patients had significantly lower mean Hb and serum iron level (for women only) as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/RAS patients had a significantly higher MCV and a significantly greater frequency of vitamin B12 deficiency than Abs−/RAS patients. Furthermore, Abs−/RAS patients did have significantly lower mean Hb, MCV, iron, and folic acid levels and significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Of 31 GPCA+/RAS patients, 3 (9.7%) had PA, 6 (19.4%) had vitamin B12 deficiency, and 3 (9.7%) had macrocytosis. Moreover, normocytic anemia (54.0%) and iron deficiency anemia (26.4%) are the two more common types of anemia in our RAS patients. Conclusions: We conclude that serum GPCA plays a significant role in causing vitamin B12 deficiency and high MCV in GPCA+/RAS patients. RAS itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA+/RAS and Abs−/RAS patients.http://www.sciencedirect.com/science/article/pii/S0929664616302686Anti-gastric parietal cell antibodyRecurrent aphthous stomatitisIronMacrocytosisAnemiaVitamin B12 deficiency |
| spellingShingle | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients Journal of the Formosan Medical Association Anti-gastric parietal cell antibody Recurrent aphthous stomatitis Iron Macrocytosis Anemia Vitamin B12 deficiency |
| title | Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients |
| title_full | Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients |
| title_fullStr | Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients |
| title_full_unstemmed | Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients |
| title_short | Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients |
| title_sort | anemia and hematinic deficiencies in anti gastric parietal cell antibody positive or all autoantibodies negative recurrent aphthous stomatitis patients |
| topic | Anti-gastric parietal cell antibody Recurrent aphthous stomatitis Iron Macrocytosis Anemia Vitamin B12 deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S0929664616302686 |
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