GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS
The major histocompatibility complex (HLA system) is one of the most polymorphic human genetic systems. The distribution of HLA-alleles and haplotypes differs within ethnic groups and geographical regions. Russian populations formed in different regions of Russia may have the different immunogenetic...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2019-08-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2886 |
| _version_ | 1826534010372751360 |
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| author | Elena Vital’evna Kuzmich Irina Evgenievna Pavlova Ludmila Nikolaevna Bubnova |
| author_facet | Elena Vital’evna Kuzmich Irina Evgenievna Pavlova Ludmila Nikolaevna Bubnova |
| author_sort | Elena Vital’evna Kuzmich |
| collection | DOAJ |
| description | The major histocompatibility complex (HLA system) is one of the most polymorphic human genetic systems. The distribution of HLA-alleles and haplotypes differs within ethnic groups and geographical regions. Russian populations formed in different regions of Russia may have the different immunogenetic characteristics due to the influence of internal and external factors (significant territory of Russia, multinational population, interethnic contacts). The aim of this study was to determine the genetic distances between Russians from different regions of Russia and other populations. According to the study, Russians living in St. Petersburg, Nizhny Novgorod and Rostov-on-Don had a similar distribution of HLA allele groups. The pan-European HLA haplotypes A*01-B*08-C*07-DRB1*03-DQB1*02 and A*03-B*07-C*07-DRB1*15-DQB1*06 were the most common in Russians of all regions. Nine out of ten of the most common HLA haplotypes in residents of St. Petersburg and Nizhny Novgorod coincided. In addition to those mentioned above, they were: A*02-B*13-C*06-DRB1*07-DQB1*02, A*03-B*35-C*04-DRB1*01-DQB1*05, A*02-B*07-C*07-DRB1*15-DQB1*06, A*02-B*18-C*07-DRB1*11-DQB1*03, A*25-B*18-C*12-DRB1*15-DQB1*06, A*02-B*41-C*17-DRB1*13-DQB1*03, A*30-B*13-C*06-DRB1*07-DQB1*02. The haplotype A*02-B*15-C*03-DRB1*04-DQB1*03 was one from the most common among Russians of St. Petersburg, but its frequency was less in Russians of Nizhny Novgorod (0,0119 vs. 0,0034, p=0,03) and it was not established in Russians of Rostov-on-Don. The residents of Rostov-on-Don had the more significant differences of the HLA-haplotype profile. In particular, the following HLA-haplotypes were among the most common in Russians of Rostov-on-Don: A*23-B*44-C*04-DRB1*07-DQB1*02, A*02-B*57-C*06-DRB1*07-DQB1*03, A*24-B*35-C*04-DRB1*11-DQB1*03, A*01-B*52-C*12-DRB1*15-DQB1*06, A*11-B*35-C*04-DRB1*01-DQB1*05, A*02-B*27-C*02-DRB1*01-DQB1*05, A*02-B*44-C*02-DRB1*16-DQB1*05. Two of these haplotypes (A*24-B*35-C*04-DRB1*11-DQB1*03 and A*02-B*44-C*02-DRB1*16-DQB1*05) were not established in Russians of Nizhny Novgorod, the other haplotypes frequency was less than 0,01. These haplotypes frequency in Russians of St. Petersburg was also less than 0,01. The haplotype A*23-B*44-C*04-DRB1*07-DQB1*02 was significantly less common in Russians of St. Petersburg (0,0246 vs. 0,0062, p=0,01). An analysis of genetic distances between populations showed that Russians of Nizhny Novgorod, as well as Russians of Moscow and Belarusians were the closest to the Russians living in St. Petersburg. Genetic distance between Russians living in St. Petersburg and the residents of Rostov-on-Don and Chelyabinsk Region is a bit greater. Comparison of genetic distances between the various Slavic populations showed that the Eastern (Belarusians, Russians) and Western (Poles, Slovaks, Czechs) Slavs are closest to each other. Populations of Southern Slavs (Serbs, Croats, Macedonians) are more remote. The results of the performed research can be used to study the processes of ethnogenesis, conduct scientific research of HLA and diseases, and also be applied in the practical activities of hematopoietic stem cell donor registries. |
| first_indexed | 2024-03-08T05:46:38Z |
| format | Article |
| id | doaj.art-662e689963914724aa655bf1337ca49e |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:16:13Z |
| publishDate | 2019-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-662e689963914724aa655bf1337ca49e2025-03-11T17:59:16ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2019-08-010010.15789/1563-0625-GDB-28861826GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONSElena Vital’evna Kuzmich0Irina Evgenievna Pavlova1Ludmila Nikolaevna Bubnova2Russian Research Institute of haematology and transfusiology, Federal Medical and Bilogical AgencyRussian Research Institute of haematology and transfusiology, Federal Medical and Bilogical AgencyRussian Research Institute of haematology and transfusiology, Federal Medical and Bilogical Agency, Professor, Department of Immunology, First St. Petersburg State I. Pavlov Medical UniversityThe major histocompatibility complex (HLA system) is one of the most polymorphic human genetic systems. The distribution of HLA-alleles and haplotypes differs within ethnic groups and geographical regions. Russian populations formed in different regions of Russia may have the different immunogenetic characteristics due to the influence of internal and external factors (significant territory of Russia, multinational population, interethnic contacts). The aim of this study was to determine the genetic distances between Russians from different regions of Russia and other populations. According to the study, Russians living in St. Petersburg, Nizhny Novgorod and Rostov-on-Don had a similar distribution of HLA allele groups. The pan-European HLA haplotypes A*01-B*08-C*07-DRB1*03-DQB1*02 and A*03-B*07-C*07-DRB1*15-DQB1*06 were the most common in Russians of all regions. Nine out of ten of the most common HLA haplotypes in residents of St. Petersburg and Nizhny Novgorod coincided. In addition to those mentioned above, they were: A*02-B*13-C*06-DRB1*07-DQB1*02, A*03-B*35-C*04-DRB1*01-DQB1*05, A*02-B*07-C*07-DRB1*15-DQB1*06, A*02-B*18-C*07-DRB1*11-DQB1*03, A*25-B*18-C*12-DRB1*15-DQB1*06, A*02-B*41-C*17-DRB1*13-DQB1*03, A*30-B*13-C*06-DRB1*07-DQB1*02. The haplotype A*02-B*15-C*03-DRB1*04-DQB1*03 was one from the most common among Russians of St. Petersburg, but its frequency was less in Russians of Nizhny Novgorod (0,0119 vs. 0,0034, p=0,03) and it was not established in Russians of Rostov-on-Don. The residents of Rostov-on-Don had the more significant differences of the HLA-haplotype profile. In particular, the following HLA-haplotypes were among the most common in Russians of Rostov-on-Don: A*23-B*44-C*04-DRB1*07-DQB1*02, A*02-B*57-C*06-DRB1*07-DQB1*03, A*24-B*35-C*04-DRB1*11-DQB1*03, A*01-B*52-C*12-DRB1*15-DQB1*06, A*11-B*35-C*04-DRB1*01-DQB1*05, A*02-B*27-C*02-DRB1*01-DQB1*05, A*02-B*44-C*02-DRB1*16-DQB1*05. Two of these haplotypes (A*24-B*35-C*04-DRB1*11-DQB1*03 and A*02-B*44-C*02-DRB1*16-DQB1*05) were not established in Russians of Nizhny Novgorod, the other haplotypes frequency was less than 0,01. These haplotypes frequency in Russians of St. Petersburg was also less than 0,01. The haplotype A*23-B*44-C*04-DRB1*07-DQB1*02 was significantly less common in Russians of St. Petersburg (0,0246 vs. 0,0062, p=0,01). An analysis of genetic distances between populations showed that Russians of Nizhny Novgorod, as well as Russians of Moscow and Belarusians were the closest to the Russians living in St. Petersburg. Genetic distance between Russians living in St. Petersburg and the residents of Rostov-on-Don and Chelyabinsk Region is a bit greater. Comparison of genetic distances between the various Slavic populations showed that the Eastern (Belarusians, Russians) and Western (Poles, Slovaks, Czechs) Slavs are closest to each other. Populations of Southern Slavs (Serbs, Croats, Macedonians) are more remote. The results of the performed research can be used to study the processes of ethnogenesis, conduct scientific research of HLA and diseases, and also be applied in the practical activities of hematopoietic stem cell donor registries.https://www.mimmun.ru/mimmun/article/view/2886genetic distancespopulation studiesrussianshla-haplotypeshla-genesphylogenetic tree |
| spellingShingle | Elena Vital’evna Kuzmich Irina Evgenievna Pavlova Ludmila Nikolaevna Bubnova GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS Медицинская иммунология genetic distances population studies russians hla-haplotypes hla-genes phylogenetic tree |
| title | GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS |
| title_full | GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS |
| title_fullStr | GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS |
| title_full_unstemmed | GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS |
| title_short | GENETIC DISTANCES BETWEEN RUSSIANS OF DIFFERENT REGIONS OF RUSSIA AND OTHER POPULATIONS |
| title_sort | genetic distances between russians of different regions of russia and other populations |
| topic | genetic distances population studies russians hla-haplotypes hla-genes phylogenetic tree |
| url | https://www.mimmun.ru/mimmun/article/view/2886 |
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