An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter
BackgroundDietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms.ObjectiveOur study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS).M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1168715/full |
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| author | Tamires dos Santos Vieira Flávia Vitorino Freitas Luiz Cláudio Barreto Silva Neto Aline Ribeiro Borçoi Suzanny Oliveira Mendes Amanda Sgrancio Olinda Ivana Alece Arantes Moreno Bárbara Risse Quaioto Marcele Lorentz Mattos de Souza Wagner Miranda Barbosa Juliana Krüger Arpini Bruna Pereira Sorroche Julia de Assis Pinheiro Anderson Barros Archanjo Joaquim Gasparini dos Santos Lidia Maria Rebolho Batista Arantes Daniela Rodrigues de Oliveira Adriana Madeira Alvares da Silva Adriana Madeira Alvares da Silva |
| author_facet | Tamires dos Santos Vieira Flávia Vitorino Freitas Luiz Cláudio Barreto Silva Neto Aline Ribeiro Borçoi Suzanny Oliveira Mendes Amanda Sgrancio Olinda Ivana Alece Arantes Moreno Bárbara Risse Quaioto Marcele Lorentz Mattos de Souza Wagner Miranda Barbosa Juliana Krüger Arpini Bruna Pereira Sorroche Julia de Assis Pinheiro Anderson Barros Archanjo Joaquim Gasparini dos Santos Lidia Maria Rebolho Batista Arantes Daniela Rodrigues de Oliveira Adriana Madeira Alvares da Silva Adriana Madeira Alvares da Silva |
| author_sort | Tamires dos Santos Vieira |
| collection | DOAJ |
| description | BackgroundDietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms.ObjectiveOur study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS).MethodsWe recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40–47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models (p < 0.05). Lifestyle variables and health variables were included as confounding factors.ResultsThe findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40–43), and methylation in component 2 (44–47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response.ConclusionThese findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia. |
| first_indexed | 2024-04-24T14:25:41Z |
| format | Article |
| id | doaj.art-662eaf405ade45c38dfe32de3420c239 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-24T14:25:41Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-662eaf405ade45c38dfe32de3420c2392024-04-03T05:02:13ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-04-011110.3389/fnut.2024.11687151168715An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoterTamires dos Santos Vieira0Flávia Vitorino Freitas1Luiz Cláudio Barreto Silva Neto2Aline Ribeiro Borçoi3Suzanny Oliveira Mendes4Amanda Sgrancio Olinda5Ivana Alece Arantes Moreno6Bárbara Risse Quaioto7Marcele Lorentz Mattos de Souza8Wagner Miranda Barbosa9Juliana Krüger Arpini10Bruna Pereira Sorroche11Julia de Assis Pinheiro12Anderson Barros Archanjo13Joaquim Gasparini dos Santos14Lidia Maria Rebolho Batista Arantes15Daniela Rodrigues de Oliveira16Adriana Madeira Alvares da Silva17Adriana Madeira Alvares da Silva18Program of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre, BrazilProgram of Post-Graduation in Nutrition and Health, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilDepartment of Morphology, Federal University of Espirito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre, BrazilDepartment of Biology, Federal University of Espirito Santo, Alegre, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, BrazilDepartment of Pharmacology and Medical Toxicology, College of Wisconsin, Milwaukee, WI, United StatesProgram of Post-Graduation in Biotechnology/Renorbio, Federal University of Espírito Santo, Vitória, BrazilDepartment of Morphology, Federal University of Espirito Santo, Vitória, BrazilBackgroundDietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms.ObjectiveOur study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS).MethodsWe recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40–47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models (p < 0.05). Lifestyle variables and health variables were included as confounding factors.ResultsThe findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40–43), and methylation in component 2 (44–47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response.ConclusionThese findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.https://www.frontiersin.org/articles/10.3389/fnut.2024.1168715/fullNR3C1 DNA methylationfood consumptionlifestylemetabolic stresschronic diseasesdiet’s composition |
| spellingShingle | Tamires dos Santos Vieira Flávia Vitorino Freitas Luiz Cláudio Barreto Silva Neto Aline Ribeiro Borçoi Suzanny Oliveira Mendes Amanda Sgrancio Olinda Ivana Alece Arantes Moreno Bárbara Risse Quaioto Marcele Lorentz Mattos de Souza Wagner Miranda Barbosa Juliana Krüger Arpini Bruna Pereira Sorroche Julia de Assis Pinheiro Anderson Barros Archanjo Joaquim Gasparini dos Santos Lidia Maria Rebolho Batista Arantes Daniela Rodrigues de Oliveira Adriana Madeira Alvares da Silva Adriana Madeira Alvares da Silva An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter Frontiers in Nutrition NR3C1 DNA methylation food consumption lifestyle metabolic stress chronic diseases diet’s composition |
| title | An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter |
| title_full | An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter |
| title_fullStr | An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter |
| title_full_unstemmed | An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter |
| title_short | An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter |
| title_sort | industrialized diet as a determinant of methylation in the 1f region of the nr3c1 gene promoter |
| topic | NR3C1 DNA methylation food consumption lifestyle metabolic stress chronic diseases diet’s composition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1168715/full |
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