Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study
Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adip...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-12-01
|
| Series: | Clinical Medicine Insights: Endocrinology and Diabetes |
| Online Access: | https://doi.org/10.1177/11795514231218592 |
| _version_ | 1797389207842324480 |
|---|---|
| author | Yaw A Kusi-Mensah Charles Hayfron-Benjamin Sean Chetty Eva L van der Linden Karlijn AC Meeks Erik Beune Frederick Anokye-Danso Rexford S Ahima Bert-Jan van den Born Charles Agyemang |
| author_facet | Yaw A Kusi-Mensah Charles Hayfron-Benjamin Sean Chetty Eva L van der Linden Karlijn AC Meeks Erik Beune Frederick Anokye-Danso Rexford S Ahima Bert-Jan van den Born Charles Agyemang |
| author_sort | Yaw A Kusi-Mensah |
| collection | DOAJ |
| description | Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent. Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders. Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians ( P < .001). In fully adjusted models, participants living in urban Ghana had significantly higher odds of hyperleptinemia compared to rural participants (women-odds ratio 2.88; 95% CI, 1.12-7.38, P = .028 and men 43.52, 95% CI, 4.84-391.25, P < .001). Urban Ghanaian men also had higher odds of elevated leptin: adiponectin ratio (6.29, 95% CI, 1.43-27.62, P = .015). The odds of hyperleptinemia were only higher in Amsterdam Ghanaian men (10.56; 95% CI, 1.11-100.85, P = .041), but not in women (0.85; 95% CI, 0.30-2.41, P = .759). There was no significant association between hypoadiponectinemia and geographical location in both sexes. Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans. |
| first_indexed | 2024-03-08T22:52:30Z |
| format | Article |
| id | doaj.art-662ee7b612b14191b47c7b460210ded4 |
| institution | Directory Open Access Journal |
| issn | 1179-5514 |
| language | English |
| last_indexed | 2024-03-08T22:52:30Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Endocrinology and Diabetes |
| spelling | doaj.art-662ee7b612b14191b47c7b460210ded42023-12-16T10:03:36ZengSAGE PublishingClinical Medicine Insights: Endocrinology and Diabetes1179-55142023-12-011610.1177/11795514231218592Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM StudyYaw A Kusi-Mensah0Charles Hayfron-Benjamin1Sean Chetty2Eva L van der Linden3Karlijn AC Meeks4Erik Beune5Frederick Anokye-Danso6Rexford S Ahima7Bert-Jan van den Born8Charles Agyemang9Department of Anaesthesiology and Critical Care, Faculty of Medicine and Health Sciences, Stellenbosch University (Tygerberg Hospital), Cape Town, South AfricaDepartment of Anaesthesia and Critical Care, University of Ghana Medical School, Accra, GhanaDepartment of Anaesthesiology and Critical Care, Faculty of Medicine and Health Sciences, Stellenbosch University (Tygerberg Hospital), Cape Town, South AfricaDepartment of Vascular Medicine, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USADepartment of Public & Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Vascular Medicine, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USABackground: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified. Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent. Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders. Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians ( P < .001). In fully adjusted models, participants living in urban Ghana had significantly higher odds of hyperleptinemia compared to rural participants (women-odds ratio 2.88; 95% CI, 1.12-7.38, P = .028 and men 43.52, 95% CI, 4.84-391.25, P < .001). Urban Ghanaian men also had higher odds of elevated leptin: adiponectin ratio (6.29, 95% CI, 1.43-27.62, P = .015). The odds of hyperleptinemia were only higher in Amsterdam Ghanaian men (10.56; 95% CI, 1.11-100.85, P = .041), but not in women (0.85; 95% CI, 0.30-2.41, P = .759). There was no significant association between hypoadiponectinemia and geographical location in both sexes. Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans.https://doi.org/10.1177/11795514231218592 |
| spellingShingle | Yaw A Kusi-Mensah Charles Hayfron-Benjamin Sean Chetty Eva L van der Linden Karlijn AC Meeks Erik Beune Frederick Anokye-Danso Rexford S Ahima Bert-Jan van den Born Charles Agyemang Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study Clinical Medicine Insights: Endocrinology and Diabetes |
| title | Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study |
| title_full | Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study |
| title_fullStr | Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study |
| title_full_unstemmed | Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study |
| title_short | Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study |
| title_sort | serum adiponectin and leptin among ghanaian migrants in amsterdam and their compatriots in rural and urban ghana the rodam study |
| url | https://doi.org/10.1177/11795514231218592 |
| work_keys_str_mv | AT yawakusimensah serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT charleshayfronbenjamin serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT seanchetty serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT evalvanderlinden serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT karlijnacmeeks serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT erikbeune serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT frederickanokyedanso serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT rexfordsahima serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT bertjanvandenborn serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy AT charlesagyemang serumadiponectinandleptinamongghanaianmigrantsinamsterdamandtheircompatriotsinruralandurbanghanatherodamstudy |