Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
Gaussian accelerated molecular dynamics (GaMD) simulations and biochemical experiments in E.Coli provide mechanistic insight into how Presenilin-1 familial Alzheimer’s disease mutations affect structural dynamics and enzyme-substrate interactions of γ-secretase and APP
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04539-1 |