First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil
<i>Klebsiella pneumoniae</i> appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by <i>K. pneumoniae</i> in cancer patients treated at an on...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.mdpi.com/2036-7449/12/3/21 |
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| author | Anderson Lineu Siqueira dos Santos Yan Corrêa Rodrigues Marcos Vinícios Hino de Melo Pabllo Antonny Silva dos Santos Tatyellen Natasha da Costa Oliveira Daniele Melo Sardinha Luana Nepomuceno Gondim Costa Lima Danielle Murici Brasiliense Karla Valéria Batista Lima |
| author_facet | Anderson Lineu Siqueira dos Santos Yan Corrêa Rodrigues Marcos Vinícios Hino de Melo Pabllo Antonny Silva dos Santos Tatyellen Natasha da Costa Oliveira Daniele Melo Sardinha Luana Nepomuceno Gondim Costa Lima Danielle Murici Brasiliense Karla Valéria Batista Lima |
| author_sort | Anderson Lineu Siqueira dos Santos |
| collection | DOAJ |
| description | <i>Klebsiella pneumoniae</i> appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by <i>K. pneumoniae</i> in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by <i>K. pneumoniae</i> 72 h after hospital admission. <i>K. pneumoniae</i> isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR <i>K. pneumoniae</i> isolates was observed, including two colistin-resistant isolates and seven isolates harboring bla<sub>KPC-1</sub> gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by <i>K. pneumoniae</i> in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of <i>K. pneumoniae</i> in the region. |
| first_indexed | 2024-03-10T14:17:28Z |
| format | Article |
| id | doaj.art-662f9d91743b415a9bcfc895604c6f06 |
| institution | Directory Open Access Journal |
| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-10T14:17:28Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-662f9d91743b415a9bcfc895604c6f062023-11-20T23:39:59ZengMDPI AGInfectious Disease Reports2036-74492020-12-0112311012010.3390/idr12030021First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, BrazilAnderson Lineu Siqueira dos Santos0Yan Corrêa Rodrigues1Marcos Vinícios Hino de Melo2Pabllo Antonny Silva dos Santos3Tatyellen Natasha da Costa Oliveira4Daniele Melo Sardinha5Luana Nepomuceno Gondim Costa Lima6Danielle Murici Brasiliense7Karla Valéria Batista Lima8Parasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilEpidemiology and Health Surveillance (PPGEVS), Evandro Chagas Institute (IEC), Ananindeua 67030-000, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, BrazilBacteriology and Mycology Section, Evandro Chagas Institute (IEC), Ananindeua 67030-000, BrazilParasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, Brazil<i>Klebsiella pneumoniae</i> appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by <i>K. pneumoniae</i> in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by <i>K. pneumoniae</i> 72 h after hospital admission. <i>K. pneumoniae</i> isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR <i>K. pneumoniae</i> isolates was observed, including two colistin-resistant isolates and seven isolates harboring bla<sub>KPC-1</sub> gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by <i>K. pneumoniae</i> in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of <i>K. pneumoniae</i> in the region.https://www.mdpi.com/2036-7449/12/3/21<i>Klebsiella pneumoniae</i>neoplasmsmulti-drug resistanceBrazil |
| spellingShingle | Anderson Lineu Siqueira dos Santos Yan Corrêa Rodrigues Marcos Vinícios Hino de Melo Pabllo Antonny Silva dos Santos Tatyellen Natasha da Costa Oliveira Daniele Melo Sardinha Luana Nepomuceno Gondim Costa Lima Danielle Murici Brasiliense Karla Valéria Batista Lima First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil Infectious Disease Reports <i>Klebsiella pneumoniae</i> neoplasms multi-drug resistance Brazil |
| title | First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil |
| title_full | First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil |
| title_fullStr | First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil |
| title_full_unstemmed | First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil |
| title_short | First Insights into Clinical and Resistance Features of Infections by <i>Klebsiella pneumoniae</i> among Oncological Patients from a Referral Center in Amazon Region, Brazil |
| title_sort | first insights into clinical and resistance features of infections by i klebsiella pneumoniae i among oncological patients from a referral center in amazon region brazil |
| topic | <i>Klebsiella pneumoniae</i> neoplasms multi-drug resistance Brazil |
| url | https://www.mdpi.com/2036-7449/12/3/21 |
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