Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model
Background/Aims Changing trends in the Helicobacter pylori (H. pylori) eradication protocol have not been investigated after the publication of the third-revised Korean guideline in 2013. We aimed to analyze the clinical characteristics of H. pylori-infected patients alongside their treatment protoc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Yong Chan Lee
2022-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2022-0010.pdf |
| _version_ | 1811183346510725120 |
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| author | Seung In Seo Tae Jun Kim Yoon Jin Choi Chang Seok Bang Yong Kang Lee Moon Won Lee Su Youn Nam Woon Geon Shin |
| author_facet | Seung In Seo Tae Jun Kim Yoon Jin Choi Chang Seok Bang Yong Kang Lee Moon Won Lee Su Youn Nam Woon Geon Shin |
| author_sort | Seung In Seo |
| collection | DOAJ |
| description | Background/Aims Changing trends in the Helicobacter pylori (H. pylori) eradication protocol have not been investigated after the publication of the third-revised Korean guideline in 2013. We aimed to analyze the clinical characteristics of H. pylori-infected patients alongside their treatment protocols using a common data model (CDM). Materials and Methods A 16-year electronic health record (of 1,689,604 patients from 2004 to 2019) was converted into a CDM in Kangdong Sacred Heart Hospital. We extracted records of patients who underwent the rapid urease test or serum anti-H. pylori IgG assay. The treatment protocols were visualized using a sunburst plot. We investigated the clinical characteristics and medication history of patients who underwent a urea breath test after clarithromycin-based eradication therapy. Results Out of 29,458 patients tested for H. pylori infection, 7,647 received a treatment protocol. Among them, 72.5% received a 7~14 days protocol comprising a proton pump inhibitor (PPI), amoxicillin, and clarithromycin. The proportion of patients treated with the first-line protocol (PPI, bismuth, tetracycline, and metronidazole) slightly increased from 1.9% (before 2014) to 3.3% (after 2014) (P<0.001). The percentages of patients with of previous exposure to macrolides (14.7% vs. 5.5%, P<0.001) or amoxicillin (10.6% vs. 7.3%, P=0.006) were higher in patients with previous clarithromycin-based eradication failure. Conclusions The H. pylori treatment protocol was not significantly modified despite the updates in the clinical guideline. There was only 1.4 percentage point increase in bismuth-based quadruple therapy as first-line eradication therapy even after the announcement of revised Korean guideline in 2013. |
| first_indexed | 2024-04-11T09:46:24Z |
| format | Article |
| id | doaj.art-662fa7d446c349daa23056c10d265a46 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-04-11T09:46:24Z |
| publishDate | 2022-09-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-662fa7d446c349daa23056c10d265a462022-12-22T04:30:58ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312022-09-0122321422110.7704/kjhugr.2022.0010737Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data ModelSeung In Seo0Tae Jun Kim1Yoon Jin Choi2Chang Seok Bang3Yong Kang Lee4Moon Won Lee5Su Youn Nam6Woon Geon Shin7 Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaBackground/Aims Changing trends in the Helicobacter pylori (H. pylori) eradication protocol have not been investigated after the publication of the third-revised Korean guideline in 2013. We aimed to analyze the clinical characteristics of H. pylori-infected patients alongside their treatment protocols using a common data model (CDM). Materials and Methods A 16-year electronic health record (of 1,689,604 patients from 2004 to 2019) was converted into a CDM in Kangdong Sacred Heart Hospital. We extracted records of patients who underwent the rapid urease test or serum anti-H. pylori IgG assay. The treatment protocols were visualized using a sunburst plot. We investigated the clinical characteristics and medication history of patients who underwent a urea breath test after clarithromycin-based eradication therapy. Results Out of 29,458 patients tested for H. pylori infection, 7,647 received a treatment protocol. Among them, 72.5% received a 7~14 days protocol comprising a proton pump inhibitor (PPI), amoxicillin, and clarithromycin. The proportion of patients treated with the first-line protocol (PPI, bismuth, tetracycline, and metronidazole) slightly increased from 1.9% (before 2014) to 3.3% (after 2014) (P<0.001). The percentages of patients with of previous exposure to macrolides (14.7% vs. 5.5%, P<0.001) or amoxicillin (10.6% vs. 7.3%, P=0.006) were higher in patients with previous clarithromycin-based eradication failure. Conclusions The H. pylori treatment protocol was not significantly modified despite the updates in the clinical guideline. There was only 1.4 percentage point increase in bismuth-based quadruple therapy as first-line eradication therapy even after the announcement of revised Korean guideline in 2013.http://www.helicojournal.org/upload/pdf/kjhugr-2022-0010.pdfcommon data model treatment |
| spellingShingle | Seung In Seo Tae Jun Kim Yoon Jin Choi Chang Seok Bang Yong Kang Lee Moon Won Lee Su Youn Nam Woon Geon Shin Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model The Korean Journal of Helicobacter and Upper Gastrointestinal Research common data model treatment |
| title | Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model |
| title_full | Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model |
| title_fullStr | Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model |
| title_full_unstemmed | Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model |
| title_short | Clinical Characteristics and Treatment Pathway of Patients Treated with Helicobacter pylori Infection-A Single Center Cohort Study Using Common Data Model |
| title_sort | clinical characteristics and treatment pathway of patients treated with helicobacter pylori infection a single center cohort study using common data model |
| topic | common data model treatment |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2022-0010.pdf |
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