URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES
Background: Urinary tract infections occur more often in newborns than older children. With our research, we wanted to analyze the clinical picture and the connection with structural abnormalities of the urinary tract and create an overview of the disease agents and their sensitivity to antibiotics....
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| Format: | Article |
| Language: | Slovenian |
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The Society for Children with Metabolic Disorders
2023-10-01
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| Series: | Slovenska pediatrija |
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| Online Access: |
http://www.slovenskapediatrija.si/Portals/0/Clanki/2023/Slovpediatr-2023-3-02en.pdf
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| _version_ | 1827794241987805184 |
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| author | Helena Klar Tina Koren Mojca Kavčič |
| author_facet | Helena Klar Tina Koren Mojca Kavčič |
| author_sort | Helena Klar |
| collection | DOAJ |
| description | Background: Urinary tract infections occur more often in newborns than older children. With our research, we wanted to analyze the clinical picture and the connection with structural abnormalities of the urinary tract and create an overview of the disease agents and their sensitivity to antibiotics.
Methods: The retrospective study included hospitalized newborns due to urinary tract infections at the Clinical Department for Neonatology of the Paediatric Clinic between 2013 and 2021. Data were obtained using the Clinical Information System.
Results: This research included 274 newborns, of which 69% were boys. The percentage of patients with associated urinary tract anomalies was 39,8%. Clinical signs upon admission were nonspecific; the most common were fever (37.1%), poor feeding (21.5%) and irritation or inconsolable weeping (17.1%). The most commonly discovered pathogen was Escherichia coli (E. coli) (60.4%). Antibiotic treatment was primarily given in the parenteral form (74.8%) and lasted, on average, 9,6 days, with a median of 7 days. The most commonly chosen empiric antibiotic therapy was therapy with ampicillin and gentamicin (61.3%). In 36.5%, the isolated bacteria were resistant to one of the tested antibiotics: Escherichia coli was most often resistant to ampicillin (36.7%) and in 1.8% to gentamicin. Conclusion: Clinical signs of urinary tract infection in neonates are nonspecific. A high percentage of newborns have associated urinary tract anomalies. The average age at the onset of the first signs of the disease is lower in newborns with congenital urinary tract anomalies. In this group of patients, Escherichia coli, as the most commonly isolated pathogen, occurs in a lower percentage and is resistant to ampicillin in a third of the cases and rarely to gentamicin. |
| first_indexed | 2024-03-11T18:29:56Z |
| format | Article |
| id | doaj.art-6631b8f7dbc24e3c844a95b061f1b495 |
| institution | Directory Open Access Journal |
| issn | 1318-4423 2712-3960 |
| language | Slovenian |
| last_indexed | 2024-03-11T18:29:56Z |
| publishDate | 2023-10-01 |
| publisher | The Society for Children with Metabolic Disorders |
| record_format | Article |
| series | Slovenska pediatrija |
| spelling | doaj.art-6631b8f7dbc24e3c844a95b061f1b4952023-10-13T12:10:44ZslvThe Society for Children with Metabolic DisordersSlovenska pediatrija1318-44232712-39602023-10-0130312413010.38031/slovpediatr-2023-3-02en13184423URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIESHelena Klar0Tina Koren1Mojca Kavčič2 Splošna bolnišnica Murska Sobota, Murska Sobota, Slovenija Zdravstveni dom Murska Sobota, Murska Sobota, Slovenija Klinični oddelek za neonatologijo, Pediatrična klinika, Univerzitetni klinični center Ljubljana, Ljubljana, Slovenija Background: Urinary tract infections occur more often in newborns than older children. With our research, we wanted to analyze the clinical picture and the connection with structural abnormalities of the urinary tract and create an overview of the disease agents and their sensitivity to antibiotics. Methods: The retrospective study included hospitalized newborns due to urinary tract infections at the Clinical Department for Neonatology of the Paediatric Clinic between 2013 and 2021. Data were obtained using the Clinical Information System. Results: This research included 274 newborns, of which 69% were boys. The percentage of patients with associated urinary tract anomalies was 39,8%. Clinical signs upon admission were nonspecific; the most common were fever (37.1%), poor feeding (21.5%) and irritation or inconsolable weeping (17.1%). The most commonly discovered pathogen was Escherichia coli (E. coli) (60.4%). Antibiotic treatment was primarily given in the parenteral form (74.8%) and lasted, on average, 9,6 days, with a median of 7 days. The most commonly chosen empiric antibiotic therapy was therapy with ampicillin and gentamicin (61.3%). In 36.5%, the isolated bacteria were resistant to one of the tested antibiotics: Escherichia coli was most often resistant to ampicillin (36.7%) and in 1.8% to gentamicin. Conclusion: Clinical signs of urinary tract infection in neonates are nonspecific. A high percentage of newborns have associated urinary tract anomalies. The average age at the onset of the first signs of the disease is lower in newborns with congenital urinary tract anomalies. In this group of patients, Escherichia coli, as the most commonly isolated pathogen, occurs in a lower percentage and is resistant to ampicillin in a third of the cases and rarely to gentamicin. http://www.slovenskapediatrija.si/Portals/0/Clanki/2023/Slovpediatr-2023-3-02en.pdf urinary tract infectionnewbornurine cultureescherichia colicongenital abnormalitiesantibiotic resistance |
| spellingShingle | Helena Klar Tina Koren Mojca Kavčič URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES Slovenska pediatrija urinary tract infection newborn urine culture escherichia coli congenital abnormalities antibiotic resistance |
| title | URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES |
| title_full | URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES |
| title_fullStr | URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES |
| title_full_unstemmed | URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES |
| title_short | URINARY TRACT INFECTIONS IN NEONATES: CLINICAL PRESENTATION, CAUSATIVE AGENTS, AND ASSOCIATION WITH STRUCTURAL URINARY TRACT ANOMALIES |
| title_sort | urinary tract infections in neonates clinical presentation causative agents and association with structural urinary tract anomalies |
| topic | urinary tract infection newborn urine culture escherichia coli congenital abnormalities antibiotic resistance |
| url |
http://www.slovenskapediatrija.si/Portals/0/Clanki/2023/Slovpediatr-2023-3-02en.pdf
|
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