Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports
Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human int...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2020-07-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100720&tlng=en |
| _version_ | 1828338816204668928 |
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| author | Bo Wei Xiaofeng Hang Ying Xie Yuanjing Zhang Jianrong Wang Xinghao Cao Jinzi J. Wu Junxue Wang |
| author_facet | Bo Wei Xiaofeng Hang Ying Xie Yuanjing Zhang Jianrong Wang Xinghao Cao Jinzi J. Wu Junxue Wang |
| author_sort | Bo Wei |
| collection | DOAJ |
| description | Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA. |
| first_indexed | 2024-04-13T22:34:15Z |
| format | Article |
| id | doaj.art-6631c346ed8846cab025d83e8852e38c |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:34:15Z |
| publishDate | 2020-07-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-6631c346ed8846cab025d83e8852e38c2022-12-22T02:26:49ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-07-015310.1590/0037-8682-0372-2020Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reportsBo WeiXiaofeng HangYing XieYuanjing ZhangJianrong WangXinghao CaoJinzi J. WuJunxue Wanghttps://orcid.org/0000-0002-9127-0422Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100720&tlng=enCOVID-19AntiviralsLong-term positive SARS-CoV-2 |
| spellingShingle | Bo Wei Xiaofeng Hang Ying Xie Yuanjing Zhang Jianrong Wang Xinghao Cao Jinzi J. Wu Junxue Wang Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports Revista da Sociedade Brasileira de Medicina Tropical COVID-19 Antivirals Long-term positive SARS-CoV-2 |
| title | Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports |
| title_full | Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports |
| title_fullStr | Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports |
| title_full_unstemmed | Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports |
| title_short | Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports |
| title_sort | long term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease case reports |
| topic | COVID-19 Antivirals Long-term positive SARS-CoV-2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100720&tlng=en |
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