Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model
In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2020.1809440 |
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| author | Hairui Liu Peipei Kang Ying Liu Yifan An Yanting Hu Xiyuan Jin Xin Cao Yunfei Qi Thiyagarajan Ramesh Xiao Wang |
| author_facet | Hairui Liu Peipei Kang Ying Liu Yifan An Yanting Hu Xiyuan Jin Xin Cao Yunfei Qi Thiyagarajan Ramesh Xiao Wang |
| author_sort | Hairui Liu |
| collection | DOAJ |
| description | In this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g. acetic acid, glutamate, capsaicin, and formalin-induced nociception in mice. The anti-inflammatory effects of synthesised zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised Zinc oxide nanoparticles from V. amygdalina. The sormulated zinc oxide nanoparticles were appreciably reduced the acetic acid, glutamate, capsaicin, and formalin-induced nociceptive responses in mice. Further the zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future. |
| first_indexed | 2024-03-13T01:41:45Z |
| format | Article |
| id | doaj.art-6632beb7f3cb463f95fcaab4c44e3719 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2025-03-21T05:47:15Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-6632beb7f3cb463f95fcaab4c44e37192024-07-23T18:44:29ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-014811068107810.1080/21691401.2020.1809440Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice modelHairui Liu0Peipei Kang1Ying Liu2Yifan An3Yanting Hu4Xiyuan Jin5Xin Cao6Yunfei Qi7Thiyagarajan Ramesh8Xiao Wang9Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Anesthesiology, Department of Nantong Tumor Hospital, Nantong city, Jiangsu, ChinaDepartment of Anesthesiology, Qinghai Women and Children's Hospital Qinghai, Gansu, ChinaDepartment of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Anesthesiology, XIN FENG XIAN People's Hospital Ganzhou, Jiangxi, ChinaDepartment of Anesthesiology, PLA 949 Hospital Aletai City, Xinjiang, ChinaDepartment of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi ArabiaDepartment of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaIn this study, we synthesised the zinc oxide nanoparticles from Vernonia amygdalina and evaluated its anti-inflammatory and antinociceptive potentials against the different inflammation and pain induced mice model. The synthesised zinc oxide nanoparticles were characterised by UV, SEM, XRD and FTIR techniques. The anti-nociceptive effects of V. amygdalina were examined by different stimuli e.g. acetic acid, glutamate, capsaicin, and formalin-induced nociception in mice. The anti-inflammatory effects of synthesised zinc oxide nanoparticles were assessed by air sack assessment and the level of inflammatory cytokines were studied. The muscle tension of animals were studied through open field assessment. The present study exhibited proficient antinociceptive and anti-inflammatory actions of the synthesised Zinc oxide nanoparticles from V. amygdalina. The sormulated zinc oxide nanoparticles were appreciably reduced the acetic acid, glutamate, capsaicin, and formalin-induced nociceptive responses in mice. Further the zinc nanoparticles were exhibited the potent anti-inflammatory actions via reducing the inflammatory response and pro-inflammatory cytokines level in the mice. In conclusion, the findings of this study proved the beneficial effects of zinc oxide nanoparticles from V. amygdalina against the different pain and inflammation-induced mice. Hence, it was clear that the zinc nanoparticles from V. amygdalina could be promising antinociceptive and anti-inflammatory agent in the future.https://www.tandfonline.com/doi/10.1080/21691401.2020.1809440ZnO NPsanti-inflammatoryVernonia amygdalinaantinociceptiveopen field test |
| spellingShingle | Hairui Liu Peipei Kang Ying Liu Yifan An Yanting Hu Xiyuan Jin Xin Cao Yunfei Qi Thiyagarajan Ramesh Xiao Wang Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model Artificial Cells, Nanomedicine, and Biotechnology ZnO NPs anti-inflammatory Vernonia amygdalina antinociceptive open field test |
| title | Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model |
| title_full | Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model |
| title_fullStr | Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model |
| title_full_unstemmed | Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model |
| title_short | Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model |
| title_sort | zinc oxide nanoparticles synthesised from the vernonia amygdalina shows the anti inflammatory and antinociceptive activities in the mice model |
| topic | ZnO NPs anti-inflammatory Vernonia amygdalina antinociceptive open field test |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2020.1809440 |
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