Flavonoid-Loaded Biomaterials in Bone Defect Repair
Skeletons play an important role in the human body, and can form gaps of varying sizes once damaged. Bone defect healing involves a series of complex physiological processes and requires ideal bone defect implants to accelerate bone defect healing. Traditional grafts are often accompanied by issues...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/19/6888 |
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| author | Jiali Yang Lifeng Zhang Qiteng Ding Shuai Zhang Shuwen Sun Wencong Liu Jinhui Liu Xiao Han Chuanbo Ding |
| author_facet | Jiali Yang Lifeng Zhang Qiteng Ding Shuai Zhang Shuwen Sun Wencong Liu Jinhui Liu Xiao Han Chuanbo Ding |
| author_sort | Jiali Yang |
| collection | DOAJ |
| description | Skeletons play an important role in the human body, and can form gaps of varying sizes once damaged. Bone defect healing involves a series of complex physiological processes and requires ideal bone defect implants to accelerate bone defect healing. Traditional grafts are often accompanied by issues such as insufficient donors and disease transmission, while some bone defect implants are made of natural and synthetic polymers, which have characteristics such as good porosity, mechanical properties, high drug loading efficiency, biocompatibility and biodegradability. However, their antibacterial, antioxidant, anti-inflammatory and bone repair promoting abilities are limited. Flavonoids are natural compounds with various biological activities, such as antitumor, anti-inflammatory and analgesic. Their good anti-inflammatory, antibacterial and antioxidant activities make them beneficial for the treatment of bone defects. Several researchers have designed different types of flavonoid-loaded polymer implants for bone defects. These implants have good biocompatibility, and they can effectively promote the expression of angiogenesis factors such as VEGF and CD31, promote angiogenesis, regulate signaling pathways such as Wnt, p38, AKT, Erk and increase the levels of osteogenesis-related factors such as Runx-2, OCN, OPN significantly to accelerate the process of bone defect healing. This article reviews the effectiveness and mechanism of biomaterials loaded with flavonoids in the treatment of bone defects. Flavonoid-loaded biomaterials can effectively promote bone defect repair, but we still need to improve the overall performance of flavonoid-loaded bone repair biomaterials to improve the bioavailability of flavonoids and provide more possibilities for bone defect repair. |
| first_indexed | 2024-03-10T21:39:45Z |
| format | Article |
| id | doaj.art-6633cba12a14435dbdd129d0d3755c62 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T21:39:45Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6633cba12a14435dbdd129d0d3755c622023-11-19T14:46:56ZengMDPI AGMolecules1420-30492023-09-012819688810.3390/molecules28196888Flavonoid-Loaded Biomaterials in Bone Defect RepairJiali Yang0Lifeng Zhang1Qiteng Ding2Shuai Zhang3Shuwen Sun4Wencong Liu5Jinhui Liu6Xiao Han7Chuanbo Ding8College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, ChinaHuashikang (Shenyang) Health Industrial Group Corporation, Shenyang 110031, ChinaLooking Up Starry Sky Medical Research Center, Siping 136001, ChinaJilin Agriculture Science and Technology College, Jilin 132101, ChinaSkeletons play an important role in the human body, and can form gaps of varying sizes once damaged. Bone defect healing involves a series of complex physiological processes and requires ideal bone defect implants to accelerate bone defect healing. Traditional grafts are often accompanied by issues such as insufficient donors and disease transmission, while some bone defect implants are made of natural and synthetic polymers, which have characteristics such as good porosity, mechanical properties, high drug loading efficiency, biocompatibility and biodegradability. However, their antibacterial, antioxidant, anti-inflammatory and bone repair promoting abilities are limited. Flavonoids are natural compounds with various biological activities, such as antitumor, anti-inflammatory and analgesic. Their good anti-inflammatory, antibacterial and antioxidant activities make them beneficial for the treatment of bone defects. Several researchers have designed different types of flavonoid-loaded polymer implants for bone defects. These implants have good biocompatibility, and they can effectively promote the expression of angiogenesis factors such as VEGF and CD31, promote angiogenesis, regulate signaling pathways such as Wnt, p38, AKT, Erk and increase the levels of osteogenesis-related factors such as Runx-2, OCN, OPN significantly to accelerate the process of bone defect healing. This article reviews the effectiveness and mechanism of biomaterials loaded with flavonoids in the treatment of bone defects. Flavonoid-loaded biomaterials can effectively promote bone defect repair, but we still need to improve the overall performance of flavonoid-loaded bone repair biomaterials to improve the bioavailability of flavonoids and provide more possibilities for bone defect repair.https://www.mdpi.com/1420-3049/28/19/6888bone defectbiomaterialsflavonoids |
| spellingShingle | Jiali Yang Lifeng Zhang Qiteng Ding Shuai Zhang Shuwen Sun Wencong Liu Jinhui Liu Xiao Han Chuanbo Ding Flavonoid-Loaded Biomaterials in Bone Defect Repair Molecules bone defect biomaterials flavonoids |
| title | Flavonoid-Loaded Biomaterials in Bone Defect Repair |
| title_full | Flavonoid-Loaded Biomaterials in Bone Defect Repair |
| title_fullStr | Flavonoid-Loaded Biomaterials in Bone Defect Repair |
| title_full_unstemmed | Flavonoid-Loaded Biomaterials in Bone Defect Repair |
| title_short | Flavonoid-Loaded Biomaterials in Bone Defect Repair |
| title_sort | flavonoid loaded biomaterials in bone defect repair |
| topic | bone defect biomaterials flavonoids |
| url | https://www.mdpi.com/1420-3049/28/19/6888 |
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