Metabolomics Profiling Reveals Rehmanniae Radix Preparata Extract Protects against Glucocorticoid-Induced Osteoporosis Mainly via Intervening Steroid Hormone Biosynthesis

Metabolomics Profiling Reveals Rehmanniae Radix Preparata Extract Protects against Glucocorticoid-Induced Osteoporosis Mainly via Intervening Steroid Hormone Biosynthesis

Rehmanniae Radix Preparata (RR), the dry rhizome of Rehmannia glutinosa Libosch., is a traditional herbal medicine for improving the liver and kidney function. Ample clinical and pharmacological experiments show that RR can prevent post-menopausal osteoporosis and senile osteoporosis. In the present...

Full description

Bibliographic Details
Main Authors:	Tianshuang Xia, Xin Dong, Yiping Jiang, Liuyue Lin, Zhimin Dong, Yi Shen, Hailiang Xin, Qiaoyan Zhang, Luping Qin
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Molecules
Subjects:	Rehmanniae Radix Preparata glucocorticoid-induced osteoporosis metabolomics osteoblast steroid hormone biosynthesis
Online Access:	http://www.mdpi.com/1420-3049/24/2/253

Similar Items

Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification
by: Li Ou, et al.
Published: (2021-10-01)

Amelioration of Sensorineural Hearing Loss through Regulation of <i>Trpv1</i>, <i>Cacna1h</i>, and <i>Ngf</i> Gene Expression by a Combination of Cuscutae Semen and Rehmanniae Radix Preparata
by: Bin Na Hong, et al.
Published: (2023-04-01)

Effects of dietary incorporation of Radix rehmanniae praeparata polysaccharide on growth performance, digestive physiology, blood metabolites, meat quality, and tibia characteristics in broiler chickens
by: Bing Yang, et al.
Published: (2023-12-01)

Rehmanniae Radix Preparata (RRP) improves pain sensitization and suppresses PI3K/Akt/TRPV1 signaling pathway in estrogen deficient rats
by: Qiangqiang Jia, et al.
Published: (2022-08-01)

Variation of main components according to the number of steaming and drying of Rehmanniae radix preparata
by: Ui Joung Youn, et al.
Published: (2018-06-01)

“Quantity-effect” research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay
by: Hong-Ying Li, et al.
Published: (2020-01-01)

Rehmanniae Radix, an Effective Treatment for Patients with Various Inflammatory and Metabolic Diseases: Results from a Review of Korean Publications
by: Seok-hee Kim, et al.
Published: (2017-06-01)

Stachyose: One of the Active Fibroblast-proliferating Components in the Root of Rehmanniae Radix (地黃 dì huáng)
by: Patrick Kwok-Kin Lai, et al.
Published: (2012-07-01)

Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix
by: Jinhao Jia, et al.
Published: (2023-12-01)

Analysis of Differences in the Chemical Composition of Glycosides and Sugars between Four Forms of Fresh Rehmanniae Radix
by: Lu Xu, et al.
Published: (2023-12-01)

Exploration of the Dynamic Variations of the Characteristic Constituents and the Degradation Products of Catalpol during the Process of Radix Rehmanniae
by: Jingjing Yang, et al.
Published: (2024-02-01)

Systems response profiles to two Rehmanniae Radix formulae in metabolic syndrome patients
by: Jun-Zeng Fu, et al.
Published: (2017-05-01)

Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer’s Disease
by: Nianxin Kang, et al.
Published: (2022-06-01)

Geongangbuja-Tang Decoction and Its Active Ingredient, Aconiti Lateralis Radix Preparata, Exerts Inhibitory Effects on Heat Stress-Induced Inflammation in Mice
by: Eugene Huh, et al.
Published: (2021-07-01)

Metabolomic strategies and biochemical analysis of the effect of processed Rehmanniae radix extract on a blood-deficient rat model
by: Yang-yang Wang, et al.
Published: (2022-03-01)

Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-Derived Nitrative Damage
by: Wenting Li, et al.
Published: (2018-07-01)

Radix Glycyrrhizae Preparata Induces Cell Cycle Arrest and Induced Caspase-Dependent Apoptosis in Glioblastoma Multiforme
by: Tsung-Ying Lin, et al.
Published: (2022-10-01)

Prepared Rehmanniae Radix oligosaccharide regulates postprandial and diabetic blood glucose in mice
by: Chen-Yuan Chiu, et al.
Published: (2018-02-01)

Molecular mechanism of Cuscutae semen–radix rehmanniae praeparata in relieving reproductive injury of male rats induced with tripterygium wilfordii multiglycosides: A tandem mass tag-based proteomics analysis
by: Shanshan Han, et al.
Published: (2023-02-01)

Combination of the Herbs Radix Rehmanniae and Cornus Officinalis Mitigated Testicular Damage From Diabetes Mellitus by Enhancing Glycolysis via the AGEs/RAGE/HIF-1α Axis
by: Yuping Chen, et al.
Published: (2021-06-01)

Mechanisms of Dihuang (Rehmanniae Radix) in treating diabetic nephropathy complicated with depression based on network pharmacology
by: Lei Xing, et al.
Published: (2022-06-01)

The neuroprotective effects of Rehmanniae Radix Praeparata exerts via regulating SKN-1 mediated antioxidant system in Caenorhabditis elegans and activating Nrf2-ARE pathway in vitro
by: Ren-Juan Hao, et al.
Published: (2024-02-01)

Antidiabetic Effect of Rehmanniae Radix Based on Regulation of TRPV1 and SCD1
by: Ye Liu, et al.
Published: (2022-05-01)

Simultaneous Analysis of Saccharides between Fresh and Processed Radix Rehmanniae by HPLC and UHPLC-LTQ-Orbitrap-MS with Multivariate Statistical Analysis
by: Shujuan Xue, et al.
Published: (2018-02-01)

Potential benefits of Rehmanniae Radix after ancient rice‐steaming process in promotion of antioxidant activity in rats' health
by: Ying Zhang, et al.
Published: (2023-09-01)

Prevention of Radix Rehmanniae Preparata on Glucocorticoid-Induced Osteoporosis in Rats
by: T.X. Wu, et al.
Published: (2015-12-01)

Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer’s disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota
by: Yunfang Su, et al.
Published: (2023-02-01)

Plastomes of two Rehmannia species： comparative genomic and phylogenetic analyses
by: Jing Sun, et al.
Published: (2021-03-01)

The complete chloroplast genome sequence of Rehmannia glutinosa (Gaertn.) DC. Wild. (Rehmannia)
by: Hao Yang, et al.
Published: (2021-03-01)

The Incidence of Virus Diseases in Rehmannia glutinosa in Korea
by: Sun-Jung Kwon, et al.
Published: (2019-03-01)

Serum, spleen metabolomics and gut microbiota reveals effect of catalpol on blood deficiency syndrome caused by cyclophosphamide and acetylphenylhydrazine
by: Wensen Zhang, et al.
Published: (2023-11-01)

Transcriptome Analysis Reveals Putative Genes Involved in Iridoid Biosynthesis in Rehmannia glutinosa
by: Xianen Li, et al.
Published: (2012-10-01)

A new megastigmane from fresh roots of Rehmannia glutinosa
by: Weisheng Feng, et al.
Published: (2013-09-01)

Two complete chloroplast genome sequences and intra-species diversity for Rehmannia glutinosa (Orobanchaceae)
by: Jae-Hyeon Jeon, et al.
Published: (2019-01-01)

Dried Root of Rehmannia glutinosa Prevents Bone Loss in Ovariectomized Rats
by: Dong Wook Lim, et al.
Published: (2013-05-01)

Inhibition of Rehmannia mosaic virus Infection by Ganoderma sp. Extract
by: Mustika Ajeng Kartini Putri Pertiwi, et al.
Published: (2020-12-01)

Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection
by: Yanfeng Huang, et al.
Published: (2023-09-01)

Identification and Functional Characterization of Tyrosine Decarboxylase from <i>Rehmannia glutinosa</i>
by: Yuanjun Li, et al.
Published: (2022-03-01)

Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome
by: Wensen Zhang, et al.
Published: (2022-03-01)

EVALUATION OF THE GROWTH, YIELD AND QUALITY OF Rehmannia glutinosa (DH19) IN THE MIDLAND AND MOUNTAINOUS REGION OF NOTHERN VIETNAM
by: Pham Thanh Loan*, Hoang Thi Le Thu
Published: (2023-12-01)