| Summary: | The aim of the study was comparative analysis of guinea pig and human bone tissue due to postnatal changes of parathyroid glands morphology. The object of research were structural elements and cellular carbohydrate determinants of parathyroid glands and bone tissue with comparative characteristics of mineral exchange and parathyroid hormone levels. Were used morphometric, histochemistry, lectin histochemistry, biochemistry and immunology metods. Age- and sex-related morpho-functional and lectin histochemical peculiarities of parathyroid glands and bone tissue were investigated during postnatal ontogenesis in human and guinea pig. Correlations between DNA/RNA contents, nuclear volume of parathyrocytes, blood parathormone level with respect to Ca-, P-, and Mg- content in blood serum and bone tissue were estimated. We detected significant reduction of the width cortical layer and osseous trabecules, increased iliac bone mineralization, with simultaneous enhancement of nuclear volume and DNA/RNA content of parathyrocytes in females of groups III (aged 60-74) and IV (aged 75-90). We revealed age-related changes in lectin binding to cellular and stromal elements of parathyroid glands and bone tissue. The data extend our knowledge on the histochemical peculiarities of parathyroid glands and bone tissue during postnatal ontogenesis and under hyperparathyroidism, demonstrate possibilities of lectin application for selective labelling of chondrocytes, osteoblasts, osteocytes and osteoclasts.
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