It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i>
<i>Pseudomonas aeruginosa</i> is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning thera...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/1/42 |
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| author | Payam Behzadi Zoltán Baráth Márió Gajdács |
| author_facet | Payam Behzadi Zoltán Baráth Márió Gajdács |
| author_sort | Payam Behzadi |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning therapeutic challenge to clinicians, both in community and in hospital settings, due to their increasing prevalence of resistance, and this may lead to prolonged therapy, sequelae, and excess mortality in the affected patient population. The resistance mechanisms of <i>P. aeruginosa</i> may be classified into intrinsic and acquired resistance mechanisms. These mechanisms lead to occurrence of resistant strains against important antibiotics—relevant in the treatment of <i>P. aeruginosa</i> infections—such as β-lactams, quinolones, aminoglycosides, and colistin. The occurrence of a specific resistotype of <i>P. aeruginosa</i>, namely the emergence of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) strains, has received substantial attention from clinical microbiologists and infection control specialists; nevertheless, the available literature on this topic is still scarce. The aim of this present review paper is to provide a concise summary on the adaptability, virulence, and antibiotic resistance of <i>P. aeruginosa</i> to a readership of basic scientists and clinicians. |
| first_indexed | 2024-03-10T13:30:57Z |
| format | Article |
| id | doaj.art-66358ef024264218a7636381a6b3407a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T13:30:57Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-66358ef024264218a7636381a6b3407a2023-11-21T08:03:55ZengMDPI AGAntibiotics2079-63822021-01-011014210.3390/antibiotics10010042It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i>Payam Behzadi0Zoltán Baráth1Márió Gajdács2Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran 37541-374, IranDepartment of Prosthodontics, Faculty of Dentistry, University of Szeged, Tisza Lajos körút 62-64, 6720 Szeged, HungaryInstitute of Medical Microbiology, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary<i>Pseudomonas aeruginosa</i> is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning therapeutic challenge to clinicians, both in community and in hospital settings, due to their increasing prevalence of resistance, and this may lead to prolonged therapy, sequelae, and excess mortality in the affected patient population. The resistance mechanisms of <i>P. aeruginosa</i> may be classified into intrinsic and acquired resistance mechanisms. These mechanisms lead to occurrence of resistant strains against important antibiotics—relevant in the treatment of <i>P. aeruginosa</i> infections—such as β-lactams, quinolones, aminoglycosides, and colistin. The occurrence of a specific resistotype of <i>P. aeruginosa</i>, namely the emergence of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) strains, has received substantial attention from clinical microbiologists and infection control specialists; nevertheless, the available literature on this topic is still scarce. The aim of this present review paper is to provide a concise summary on the adaptability, virulence, and antibiotic resistance of <i>P. aeruginosa</i> to a readership of basic scientists and clinicians.https://www.mdpi.com/2079-6382/10/1/42<i>Pseudomonas aeruginosa</i>MDRcolistincephalosporincarbapenemvirulence |
| spellingShingle | Payam Behzadi Zoltán Baráth Márió Gajdács It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Antibiotics <i>Pseudomonas aeruginosa</i> MDR colistin cephalosporin carbapenem virulence |
| title | It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> |
| title_full | It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> |
| title_fullStr | It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> |
| title_full_unstemmed | It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> |
| title_short | It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> |
| title_sort | it s not easy being green a narrative review on the microbiology virulence and therapeutic prospects of multidrug resistant i pseudomonas aeruginosa i |
| topic | <i>Pseudomonas aeruginosa</i> MDR colistin cephalosporin carbapenem virulence |
| url | https://www.mdpi.com/2079-6382/10/1/42 |
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