Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma
Introduction: Juvenile xanthogranuloma (JXG) is an uncommon benign cutaneous fibrohistiocytic, self healing, class II non-Langerhan’s cell histiocytosis (NLCH). JXG accounts for 80-90% of cases of NLCH. It occurs most commonly on the head and neck of infants and young children and resolves spontaneo...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2015-08-01
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| Series: | JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) |
| Subjects: | |
| Online Access: | http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/6/pdf |
| _version_ | 1819263113306832896 |
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| author | Heru Nugraha Siti Aisah Boediardja Ridha Rosandi Evelyn Lina Nainggolan Githa Rahmayunita Triana Agustin Rahadi Rihatmadja |
| author_facet | Heru Nugraha Siti Aisah Boediardja Ridha Rosandi Evelyn Lina Nainggolan Githa Rahmayunita Triana Agustin Rahadi Rihatmadja |
| author_sort | Heru Nugraha |
| collection | DOAJ |
| description | Introduction: Juvenile xanthogranuloma (JXG) is an uncommon benign cutaneous fibrohistiocytic, self healing, class II non-Langerhan’s cell histiocytosis (NLCH). JXG accounts for 80-90% of cases of NLCH. It occurs most commonly on the head and neck of infants and young children and resolves spontaneously.
Case: A one year-old boy presented with asymptomatic, multiple yellowish, shiny, and firm nodules with telangiectasia on the surface, measuring around 1 centimeter in diameter, on the face, the trunk, the arms, and lower extremities. The first lesion appeared on the face 8 months prior to consultation then spread gradually to other areas. He was referred from another hospital and was diagnosed as molluscum contagiosum (MC) with differential diagnosis of syringoma. Enucleation had been performed but failed to produce the molluscum bodies. Initial histopathological examination provided the diagnosis of syringoma. The second histopathological examination showed dermal inflammatory cells consisting of eosinophils, lymphocytes, and histiocytes with marked foam cells and giant cells. Eccrine sweat glands were normal. Some lesions decreased in size at subsequent follow-ups; observation was advised until 3-6 years.
Discussion : JXG should be suspected in cases with multiple yellowish nodules appearing in the first year of life. MC usually presents with whitish papules, whereas syringoma is more rarely appeared, presenting with yellow-to-brownish papules. Histopathological examination can easily differentiate the suspected diagnoses; however, selection of lesion, timing and complete clinical information was crucial in reaching the final diagnosis. In this case there was a good clinicopathological correlation that the diagnosis of JXG was made with certainty. There was no eye and other organ abnormalities. |
| first_indexed | 2024-12-23T20:08:25Z |
| format | Article |
| id | doaj.art-6636415684024044bc0798843363812b |
| institution | Directory Open Access Journal |
| issn | 2460-7991 |
| language | English |
| last_indexed | 2024-12-23T20:08:25Z |
| publishDate | 2015-08-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) |
| spelling | doaj.art-6636415684024044bc0798843363812b2022-12-21T17:32:52ZengUniversitas IndonesiaJDVI (Journal of General Procedural Dermatology & Venereology Indonesia)2460-79912015-08-0111293210.19100/jdvi.v1i1.6 Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringomaHeru Nugraha0Siti Aisah Boediardja1Ridha Rosandi2Evelyn Lina Nainggolan3Githa Rahmayunita4Triana Agustin5Rahadi Rihatmadja6Department of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaDepartment of Dermatology & Venereology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, IndonesiaIntroduction: Juvenile xanthogranuloma (JXG) is an uncommon benign cutaneous fibrohistiocytic, self healing, class II non-Langerhan’s cell histiocytosis (NLCH). JXG accounts for 80-90% of cases of NLCH. It occurs most commonly on the head and neck of infants and young children and resolves spontaneously. Case: A one year-old boy presented with asymptomatic, multiple yellowish, shiny, and firm nodules with telangiectasia on the surface, measuring around 1 centimeter in diameter, on the face, the trunk, the arms, and lower extremities. The first lesion appeared on the face 8 months prior to consultation then spread gradually to other areas. He was referred from another hospital and was diagnosed as molluscum contagiosum (MC) with differential diagnosis of syringoma. Enucleation had been performed but failed to produce the molluscum bodies. Initial histopathological examination provided the diagnosis of syringoma. The second histopathological examination showed dermal inflammatory cells consisting of eosinophils, lymphocytes, and histiocytes with marked foam cells and giant cells. Eccrine sweat glands were normal. Some lesions decreased in size at subsequent follow-ups; observation was advised until 3-6 years. Discussion : JXG should be suspected in cases with multiple yellowish nodules appearing in the first year of life. MC usually presents with whitish papules, whereas syringoma is more rarely appeared, presenting with yellow-to-brownish papules. Histopathological examination can easily differentiate the suspected diagnoses; however, selection of lesion, timing and complete clinical information was crucial in reaching the final diagnosis. In this case there was a good clinicopathological correlation that the diagnosis of JXG was made with certainty. There was no eye and other organ abnormalities.http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/6/pdfJuvenile xanthogranulomaclinicopathological correlation |
| spellingShingle | Heru Nugraha Siti Aisah Boediardja Ridha Rosandi Evelyn Lina Nainggolan Githa Rahmayunita Triana Agustin Rahadi Rihatmadja Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma JDVI (Journal of General Procedural Dermatology & Venereology Indonesia) Juvenile xanthogranuloma clinicopathological correlation |
| title | Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| title_full | Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| title_fullStr | Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| title_full_unstemmed | Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| title_short | Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| title_sort | multiple juvenile xanthogranuloma a rare case of having clinical appearance mimicking molluscum contagiosum or syringoma |
| topic | Juvenile xanthogranuloma clinicopathological correlation |
| url | http://jgenprodvi.ui.ac.id/index.php/jdvi/article/view/6/pdf |
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