ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES
The lack of expression of hormone and human epidermal growth factor receptors in breast cancer conditions has made moleculartargeted therapies unsuitable and establishing therapeutic strategies are challenging for such cancers. Screening of methanolic extract of seeds of Annona muricata against 4T1...
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| Format: | Article |
| Language: | English |
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2016-07-01
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| Series: | Journal of Veterinary and Animal Sciences |
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| Online Access: | https://www.jvas.in/public_html/upload/article_file/article_file_qb2hd6.pdf?t=qb2hd6 |
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| author | K.J. Bibu P.T.A. Usha |
| author_facet | K.J. Bibu P.T.A. Usha |
| author_sort | K.J. Bibu |
| collection | DOAJ |
| description | The lack of expression of hormone and human epidermal growth factor receptors in breast cancer conditions has made moleculartargeted therapies unsuitable and establishing therapeutic strategies are challenging for such cancers. Screening of methanolic extract of seeds of Annona muricata against
4T1 triple negative breast cancer cells has showed evidenced cytotoxicity against cancer cells. Hence fractionation of the extract was carried out and the fraction was analysed for its phytochemical constituents and anti
proliferative effect. The phytoconstituents when anlaysed using Liquid Chromatography Mass Spectroscopy revealed the presence of annonaceous acetogenins. The results of the present study reveal the anti proliferative effect of chloroform fraction of methanolic extract of seeds of A. muricata. It can be concluded that the chloroform fraction of methanolic extract of A. muricata exerts anti proliferative effect due to the presence of annonaceous acetogenins. |
| first_indexed | 2024-12-19T23:48:34Z |
| format | Article |
| id | doaj.art-6637829c4b464bbca3fe898ab26d32ba |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-12-19T23:48:34Z |
| publishDate | 2016-07-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-6637829c4b464bbca3fe898ab26d32ba2022-12-21T20:01:13ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052016-07-01472912ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINESK.J. Bibu0P.T.A. Usha1Department of Veterinary Pharmacology College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala – 680 651.Department of Veterinary Pharmacology College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala – 680 651.The lack of expression of hormone and human epidermal growth factor receptors in breast cancer conditions has made moleculartargeted therapies unsuitable and establishing therapeutic strategies are challenging for such cancers. Screening of methanolic extract of seeds of Annona muricata against 4T1 triple negative breast cancer cells has showed evidenced cytotoxicity against cancer cells. Hence fractionation of the extract was carried out and the fraction was analysed for its phytochemical constituents and anti proliferative effect. The phytoconstituents when anlaysed using Liquid Chromatography Mass Spectroscopy revealed the presence of annonaceous acetogenins. The results of the present study reveal the anti proliferative effect of chloroform fraction of methanolic extract of seeds of A. muricata. It can be concluded that the chloroform fraction of methanolic extract of A. muricata exerts anti proliferative effect due to the presence of annonaceous acetogenins.https://www.jvas.in/public_html/upload/article_file/article_file_qb2hd6.pdf?t=qb2hd6lcms analysisannonaceous acetogeninsa. muricataanti proliferative effect |
| spellingShingle | K.J. Bibu P.T.A. Usha ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES Journal of Veterinary and Animal Sciences lcms analysis annonaceous acetogenins a. muricata anti proliferative effect |
| title | ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES |
| title_full | ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES |
| title_fullStr | ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES |
| title_full_unstemmed | ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES |
| title_short | ANTIPROLIFERATIVE EFFECT OF CHLOROFORMFRACTIONOFMETHANOLICEXTRACT OF SEEDS OF Annona muricata IN TRIPLE NEGATIVE BREAST CANCER CELL LINES |
| title_sort | antiproliferative effect of chloroformfractionofmethanolicextract of seeds of annona muricata in triple negative breast cancer cell lines |
| topic | lcms analysis annonaceous acetogenins a. muricata anti proliferative effect |
| url | https://www.jvas.in/public_html/upload/article_file/article_file_qb2hd6.pdf?t=qb2hd6 |
| work_keys_str_mv | AT kjbibu antiproliferativeeffectofchloroformfractionofmethanolicextractofseedsofannonamuricataintriplenegativebreastcancercelllines AT ptausha antiproliferativeeffectofchloroformfractionofmethanolicextractofseedsofannonamuricataintriplenegativebreastcancercelllines |