Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder
Fanconi anaemia is a rare, progressive congenital bone marrow failure syndrome characterised by autosomal recessive inheritance and clinical manifestations, including growth retardation, bone marrow failure leading to pancytopenia, an elevated risk of malignancy, skin pigmentation, and skeletal malf...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/19141/67539_CE[Ra1]_F(IS)_QC(PS_RDW_SHU)_PF1(VD_DK_OM)_PFA(VD_KM)_PN(KM).pdf |
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| author | Maha Mahmoud Saad AbdulMohsen AlQabbani Sumit Rajinder Bedi Sonali Vedraj Sharma |
| author_facet | Maha Mahmoud Saad AbdulMohsen AlQabbani Sumit Rajinder Bedi Sonali Vedraj Sharma |
| author_sort | Maha Mahmoud |
| collection | DOAJ |
| description | Fanconi anaemia is a rare, progressive congenital bone marrow failure syndrome characterised by autosomal recessive inheritance and clinical manifestations, including growth retardation, bone marrow failure leading to pancytopenia, an elevated risk of malignancy, skin pigmentation, and skeletal malformations. Patients who have undergone bone marrow transplantation can be treated comprehensively in the dental clinic like other routine patients, provided their blood indices are within normal limits. Its complications include aplastic anaemia, malignancies like acute myeloid leukaemia, liver tumours, and squamous cell carcinoma, often developing post-bone marrow transplantation. Dental anomalies, altered salivary flow, and increased susceptibility to cancer necessitate early diagnosis and specialised dental care. Hereby, the authors present a case of 15-year-old male with Fanconi Anaemia who had undergone bone marrow transplantation and was treated comprehensively in a hospital setting. The present case report aimed to equip healthcare practitioners, especially dentists, with the knowledge needed for accurate diagnosis and effective management. |
| first_indexed | 2024-03-07T16:15:49Z |
| format | Article |
| id | doaj.art-663c2eae536b45a983f08995293d19c6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-07T16:15:49Z |
| publishDate | 2024-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-663c2eae536b45a983f08995293d19c62024-03-04T11:11:25ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-03-011803040610.7860/JCDR/2024/67539.19141Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic DisorderMaha Mahmoud0Saad AbdulMohsen AlQabbani1Sumit Rajinder Bedi2Sonali Vedraj Sharma3Professor, Department of Biomedical Dental Sciences (Oral Medicine Division), College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Eastern Province, Saudi Arabia.Intern, Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Eastern Province, Saudi Arabia.Lecturer, Department of Preventive Dental Sciences (Paediatric Division), College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Eastern Province, Saudi Arabia.Lecturer, Department of Biomedical Dental Sciences (Oral Medicine Division), College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam, Eastern Province, Saudi Arabia.Fanconi anaemia is a rare, progressive congenital bone marrow failure syndrome characterised by autosomal recessive inheritance and clinical manifestations, including growth retardation, bone marrow failure leading to pancytopenia, an elevated risk of malignancy, skin pigmentation, and skeletal malformations. Patients who have undergone bone marrow transplantation can be treated comprehensively in the dental clinic like other routine patients, provided their blood indices are within normal limits. Its complications include aplastic anaemia, malignancies like acute myeloid leukaemia, liver tumours, and squamous cell carcinoma, often developing post-bone marrow transplantation. Dental anomalies, altered salivary flow, and increased susceptibility to cancer necessitate early diagnosis and specialised dental care. Hereby, the authors present a case of 15-year-old male with Fanconi Anaemia who had undergone bone marrow transplantation and was treated comprehensively in a hospital setting. The present case report aimed to equip healthcare practitioners, especially dentists, with the knowledge needed for accurate diagnosis and effective management.https://www.jcdr.net/articles/PDF/19141/67539_CE[Ra1]_F(IS)_QC(PS_RDW_SHU)_PF1(VD_DK_OM)_PFA(VD_KM)_PN(KM).pdfautosomal recessivebone marrow transplantationhypoplasiaperiodontitis |
| spellingShingle | Maha Mahmoud Saad AbdulMohsen AlQabbani Sumit Rajinder Bedi Sonali Vedraj Sharma Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder Journal of Clinical and Diagnostic Research autosomal recessive bone marrow transplantation hypoplasia periodontitis |
| title | Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder |
| title_full | Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder |
| title_fullStr | Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder |
| title_full_unstemmed | Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder |
| title_short | Complete Mouth Rehabilitation in a Patient with Fanconi Anaemia: A Rare Genetic Disorder |
| title_sort | complete mouth rehabilitation in a patient with fanconi anaemia a rare genetic disorder |
| topic | autosomal recessive bone marrow transplantation hypoplasia periodontitis |
| url | https://www.jcdr.net/articles/PDF/19141/67539_CE[Ra1]_F(IS)_QC(PS_RDW_SHU)_PF1(VD_DK_OM)_PFA(VD_KM)_PN(KM).pdf |
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