Single-cell RNA sequencing reveals the dynamics of hepatic non-parenchymal cells in autoprotection against acetaminophen-induced hepatotoxicity

Single-cell RNA sequencing reveals the dynamics of hepatic non-parenchymal cells in autoprotection against acetaminophen-induced hepatotoxicity

Gaining a better understanding of autoprotection against drug-induced liver injury (DILI) may provide new strategies for its prevention and therapy. However, little is known about the underlying mechanisms of this phenomenon. We used single-cell RNA sequencing to characterize the dynamics and functi...

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Bibliographic Details
Main Authors: Lingqi Yu, Jun Yan, Yingqi Zhan, Anyao Li, Lidan Zhu, Jingyang Qian, Fanfan Zhou, Xiaoyan Lu, Xiaohui Fan
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Single-cell RNA sequencing
Drug-induced liver injury
Autoprotection against APAP hepatotoxicity
Endothelial cells
Dendritic cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923000928

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http://www.sciencedirect.com/science/article/pii/S2095177923000928

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