Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women
Post-menopausal osteoporosis (PMO) is a multifactorial bone disorder in elderly women. Various vitamin D receptor (VDR) gene variants have been studied and associated with osteoporosis in other populations, but not in a homogenous Arab ethnic group. Herein, the current study explores the association...
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MDPI AG
2021-09-01
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| Series: | Current Issues in Molecular Biology |
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| author | Mohammed. G. A. Ansari Abdul Khader Mohammed Kaiser A. Wani Syed D. Hussain Abdullah M. Alnaami Saba Abdi Naji J. Aljohani Nasser M. Al-Daghri |
| author_facet | Mohammed. G. A. Ansari Abdul Khader Mohammed Kaiser A. Wani Syed D. Hussain Abdullah M. Alnaami Saba Abdi Naji J. Aljohani Nasser M. Al-Daghri |
| author_sort | Mohammed. G. A. Ansari |
| collection | DOAJ |
| description | Post-menopausal osteoporosis (PMO) is a multifactorial bone disorder in elderly women. Various vitamin D receptor (VDR) gene variants have been studied and associated with osteoporosis in other populations, but not in a homogenous Arab ethnic group. Herein, the current study explores the association between VDR polymorphisms and susceptibility to osteoporosis in Saudi postmenopausal women. In total, 600 Saudi postmenopausal women (N = 300 osteoporosis; N = 300 control) were genotyped for VDR gene variants (<i>rs7975232</i>, <i>rs1544410</i>, <i>rs731236</i>) using TaqMan<sup>®</sup> SNP genotyping assays. Bone mineral density (BMD) for the lumbar spine and femur was assessed using dual-energy X-ray absorptiometry (DEXA). The heterozygous frequency distributions AC of <i>rs7975232</i>, CT of <i>rs1544410</i>, and AG of <i>rs731236</i> were significantly higher in the osteoporosis group than controls (<i>p</i> < 0.05). Heterozygous AC of <i>rs7975232</i> (1.6; 95% CI 1.1–2.3; <i>p</i> < 0.023), CT of <i>rs1544410</i> (1.6; 95% CI 1.1–2.4; <i>p</i> < 0.022), and AG of <i>rs731236</i> (1.6; 95% CI 1.1–2.4; <i>p</i> < 0.024) were significantly associated with increased risk of osteoporosis, independent of age and BMI. In conclusion, VDR gene variants <i>rs7975232</i>, <i>rs1544410</i>, <i>rs731236</i> had a significant effect on BMD and were associated with osteoporosis risk in Saudi postmenopausal women. |
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| language | English |
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| spelling | doaj.art-663ce91ff4d34511ac061293195034952023-11-23T07:43:33ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452021-09-014331325133410.3390/cimb43030094Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal WomenMohammed. G. A. Ansari0Abdul Khader Mohammed1Kaiser A. Wani2Syed D. Hussain3Abdullah M. Alnaami4Saba Abdi5Naji J. Aljohani6Nasser M. Al-Daghri7Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaChair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaPost-menopausal osteoporosis (PMO) is a multifactorial bone disorder in elderly women. Various vitamin D receptor (VDR) gene variants have been studied and associated with osteoporosis in other populations, but not in a homogenous Arab ethnic group. Herein, the current study explores the association between VDR polymorphisms and susceptibility to osteoporosis in Saudi postmenopausal women. In total, 600 Saudi postmenopausal women (N = 300 osteoporosis; N = 300 control) were genotyped for VDR gene variants (<i>rs7975232</i>, <i>rs1544410</i>, <i>rs731236</i>) using TaqMan<sup>®</sup> SNP genotyping assays. Bone mineral density (BMD) for the lumbar spine and femur was assessed using dual-energy X-ray absorptiometry (DEXA). The heterozygous frequency distributions AC of <i>rs7975232</i>, CT of <i>rs1544410</i>, and AG of <i>rs731236</i> were significantly higher in the osteoporosis group than controls (<i>p</i> < 0.05). Heterozygous AC of <i>rs7975232</i> (1.6; 95% CI 1.1–2.3; <i>p</i> < 0.023), CT of <i>rs1544410</i> (1.6; 95% CI 1.1–2.4; <i>p</i> < 0.022), and AG of <i>rs731236</i> (1.6; 95% CI 1.1–2.4; <i>p</i> < 0.024) were significantly associated with increased risk of osteoporosis, independent of age and BMI. In conclusion, VDR gene variants <i>rs7975232</i>, <i>rs1544410</i>, <i>rs731236</i> had a significant effect on BMD and were associated with osteoporosis risk in Saudi postmenopausal women.https://www.mdpi.com/1467-3045/43/3/94VDR gene polymorphismSaudi womenbone mass density |
| spellingShingle | Mohammed. G. A. Ansari Abdul Khader Mohammed Kaiser A. Wani Syed D. Hussain Abdullah M. Alnaami Saba Abdi Naji J. Aljohani Nasser M. Al-Daghri Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women Current Issues in Molecular Biology VDR gene polymorphism Saudi women bone mass density |
| title | Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women |
| title_full | Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women |
| title_fullStr | Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women |
| title_full_unstemmed | Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women |
| title_short | Vitamin D Receptor Gene Variants Susceptible to Osteoporosis in Arab Post-Menopausal Women |
| title_sort | vitamin d receptor gene variants susceptible to osteoporosis in arab post menopausal women |
| topic | VDR gene polymorphism Saudi women bone mass density |
| url | https://www.mdpi.com/1467-3045/43/3/94 |
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