Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects
Maha J Balgoon Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Maha J Balgoon, Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia, Tel +966555762237, Email mbalgoon@kau.edu.saBackground: Bioac...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-04-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/garden-cress-lepidium-sativum-seeds-ameliorated-aluminum-induced-alzhe-peer-reviewed-fulltext-article-NDT |
| _version_ | 1797847431248871424 |
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| author | Balgoon MJ |
| author_facet | Balgoon MJ |
| author_sort | Balgoon MJ |
| collection | DOAJ |
| description | Maha J Balgoon Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Maha J Balgoon, Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia, Tel +966555762237, Email mbalgoon@kau.edu.saBackground: Bioaccumulation of aluminum in the brain is associated with adverse neuroinflammatory and neurodegenerative changes, such as those seen in Alzheimer’s disease (AD).Objective: This study aimed to assess the impact of the administration of Lepidium sativum (LS) extract on behavioral, biochemical, and cerebral histopathological changes in rats with AlCl3-induced AD and explore the mechanism behind this effect.Materials and Methods: This study was conducted on 40 male albino rats divided into four groups (n=10): LS (control, 20 mg/kg body weight for 8 weeks), AD (AlCl3, 10 mg/kg body weight), and an LS-treated AD group. Behavioral assessment included radial armed maze and active avoidance training tests. Proinflammatory cytokines, oxidant/antioxidant markers, Aβ, AchE, tau protein, TGFβ1, homocysteine, folic acid, and vitamin B12 were biochemically assessed in the serum. The cerebral cortex was histopathologically examined.Results: AlCl3 administration significantly impaired rats’ memory, indicating AD-like behavioral changes, significantly increased (P< 0.001) oxidative stress markers, enhanced proinflammatory cytokines, and significantly increased AChE (P< 0.001) adding to cytotoxic effects and neuronal loss in the cerebral cortex. LS administration significantly improved the antioxidant parameters, reduced proinflammatory cytokines, and alleviated AD-associated histopathological changes.Conclusion: LS ameliorated AlCl3-induced changes through its antioxidant, anti-inflammatory, and antiapoptotic effects, suggesting that it has a neuroprotective effect.Keywords: Lepidium sativum, aluminum, neuroinflammation, antioxidant, Aβ, AchE, tau, TGFβ1 |
| first_indexed | 2024-04-09T18:11:15Z |
| format | Article |
| id | doaj.art-663d03d015984ee5ac0b3310d0970235 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-04-09T18:11:15Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-663d03d015984ee5ac0b3310d09702352023-04-13T19:17:09ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212023-04-01Volume 1986587882994Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic EffectsBalgoon MJMaha J Balgoon Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Maha J Balgoon, Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia, Tel +966555762237, Email mbalgoon@kau.edu.saBackground: Bioaccumulation of aluminum in the brain is associated with adverse neuroinflammatory and neurodegenerative changes, such as those seen in Alzheimer’s disease (AD).Objective: This study aimed to assess the impact of the administration of Lepidium sativum (LS) extract on behavioral, biochemical, and cerebral histopathological changes in rats with AlCl3-induced AD and explore the mechanism behind this effect.Materials and Methods: This study was conducted on 40 male albino rats divided into four groups (n=10): LS (control, 20 mg/kg body weight for 8 weeks), AD (AlCl3, 10 mg/kg body weight), and an LS-treated AD group. Behavioral assessment included radial armed maze and active avoidance training tests. Proinflammatory cytokines, oxidant/antioxidant markers, Aβ, AchE, tau protein, TGFβ1, homocysteine, folic acid, and vitamin B12 were biochemically assessed in the serum. The cerebral cortex was histopathologically examined.Results: AlCl3 administration significantly impaired rats’ memory, indicating AD-like behavioral changes, significantly increased (P< 0.001) oxidative stress markers, enhanced proinflammatory cytokines, and significantly increased AChE (P< 0.001) adding to cytotoxic effects and neuronal loss in the cerebral cortex. LS administration significantly improved the antioxidant parameters, reduced proinflammatory cytokines, and alleviated AD-associated histopathological changes.Conclusion: LS ameliorated AlCl3-induced changes through its antioxidant, anti-inflammatory, and antiapoptotic effects, suggesting that it has a neuroprotective effect.Keywords: Lepidium sativum, aluminum, neuroinflammation, antioxidant, Aβ, AchE, tau, TGFβ1https://www.dovepress.com/garden-cress-lepidium-sativum-seeds-ameliorated-aluminum-induced-alzhe-peer-reviewed-fulltext-article-NDTlepidium sativum- aluminum-neuroinflammation-antioxidant-aβ- ache- tau- tgfβ1. |
| spellingShingle | Balgoon MJ Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects Neuropsychiatric Disease and Treatment lepidium sativum- aluminum-neuroinflammation-antioxidant-aβ- ache- tau- tgfβ1. |
| title | Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects |
| title_full | Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects |
| title_fullStr | Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects |
| title_full_unstemmed | Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects |
| title_short | Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects |
| title_sort | garden cress lepidium sativum seeds ameliorated aluminum induced alzheimer disease in rats through antioxidant anti inflammatory and antiapoptotic effects |
| topic | lepidium sativum- aluminum-neuroinflammation-antioxidant-aβ- ache- tau- tgfβ1. |
| url | https://www.dovepress.com/garden-cress-lepidium-sativum-seeds-ameliorated-aluminum-induced-alzhe-peer-reviewed-fulltext-article-NDT |
| work_keys_str_mv | AT balgoonmj gardencresslepidiumsativumseedsamelioratedaluminuminducedalzheimerdiseaseinratsthroughantioxidantantiinflammatoryandantiapoptoticeffects |