The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases

The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases

Abstract The disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation of histone H3 on lysine 79, was associated with the pathogenesis of many diseases, but its role in peritoneal fibrosis remained unexplored. Here, we examined the role of DOT1...

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Bibliographic Details
Main Authors: Min Tao, Yingfeng Shi, Hui Chen, Jinqing Li, Yi Wang, Xiaoyan Ma, Lin Du, Yishu Wang, Xinyu Yang, Yan Hu, Xun Zhou, Qin Zhong, Danying Yan, Andong Qiu, Shougang Zhuang, Na Liu
Format: Article
Language:English
Published: Springer 2024-01-01
Series:Molecular Biomedicine
Subjects:
Disruptor of telomeric silencing 1-like
Di-methylation of histone H3 on lysine-79
Epidermal growth factor receptor
Janus kinase 3
Peritoneal fibrosis
Online Access:https://doi.org/10.1186/s43556-023-00161-z

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