Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review
Mansour Alghamdi, Stephen J Derbes Department of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USACorrespondence: Mansour AlghamdiDepartment of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USAEmail m...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-08-01
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| Series: | International Medical Case Reports Journal |
| Subjects: | |
| Online Access: | https://www.dovepress.com/systemic-sclerosis-sine-scleroderma-manifested-with-gastrointestinal-b-peer-reviewed-article-IMCRJ |
| _version_ | 1818849408755695616 |
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| author | Alghamdi M Derbes SJ |
| author_facet | Alghamdi M Derbes SJ |
| author_sort | Alghamdi M |
| collection | DOAJ |
| description | Mansour Alghamdi, Stephen J Derbes Department of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USACorrespondence: Mansour AlghamdiDepartment of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USAEmail mmalgh@hotmail.comAbstract: Systemic sclerosis sine scleroderma (ssSSc) is a rare disease in which patients present with internal organ manifestations of systemic sclerosis in the absence of cutaneous findings. They tend to have serological markers characteristic of systemic sclerosis (SSc), including positive antinuclear antibodies (ANA) and anticentromere antibodies (ACA). The disease has been rarely reported in the literature, and the diagnosis can be easily missed due to a lack of relevant skin findings. Here we report a patient who presented with chronic gastrointestinal bleeding with angioectasia, antiphospholipid syndrome (APS), positive ANA, positive ACA, and positive anti-RNA polymerase III antibody. The constellation of all these findings has, to our knowledge, never been described in the literature. The purpose of presenting this case is to raise the clinician’s awareness of the occurrence of this disease when similar internal organs manifestations of scleroderma are encountered, and to monitor for the development of other internal manifestations and intervene promptly and accordingly.Keywords: systemic sclerosis sine scleroderma, scleroderma, systemic sclerosis, angioectasia/angiodysplasia, anti-RNA polymerase III antibody |
| first_indexed | 2024-12-19T06:32:46Z |
| format | Article |
| id | doaj.art-663fa4a019c14efc9dc44b074d22748b |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-19T06:32:46Z |
| publishDate | 2020-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-663fa4a019c14efc9dc44b074d22748b2022-12-21T20:32:20ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2020-08-01Volume 1332332655912Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature ReviewAlghamdi MDerbes SJMansour Alghamdi, Stephen J Derbes Department of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USACorrespondence: Mansour AlghamdiDepartment of Medicine, Rheumatology Section, Louisiana State University School of Medicine, New Orleans, LA, USAEmail mmalgh@hotmail.comAbstract: Systemic sclerosis sine scleroderma (ssSSc) is a rare disease in which patients present with internal organ manifestations of systemic sclerosis in the absence of cutaneous findings. They tend to have serological markers characteristic of systemic sclerosis (SSc), including positive antinuclear antibodies (ANA) and anticentromere antibodies (ACA). The disease has been rarely reported in the literature, and the diagnosis can be easily missed due to a lack of relevant skin findings. Here we report a patient who presented with chronic gastrointestinal bleeding with angioectasia, antiphospholipid syndrome (APS), positive ANA, positive ACA, and positive anti-RNA polymerase III antibody. The constellation of all these findings has, to our knowledge, never been described in the literature. The purpose of presenting this case is to raise the clinician’s awareness of the occurrence of this disease when similar internal organs manifestations of scleroderma are encountered, and to monitor for the development of other internal manifestations and intervene promptly and accordingly.Keywords: systemic sclerosis sine scleroderma, scleroderma, systemic sclerosis, angioectasia/angiodysplasia, anti-RNA polymerase III antibodyhttps://www.dovepress.com/systemic-sclerosis-sine-scleroderma-manifested-with-gastrointestinal-b-peer-reviewed-article-IMCRJsystemic sclerosis sine sclerodermasclerodermasystemic sclerosisangioectasia/ angiodysplasia. |
| spellingShingle | Alghamdi M Derbes SJ Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review International Medical Case Reports Journal systemic sclerosis sine scleroderma scleroderma systemic sclerosis angioectasia/ angiodysplasia. |
| title | Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review |
| title_full | Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review |
| title_fullStr | Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review |
| title_full_unstemmed | Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review |
| title_short | Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review |
| title_sort | systemic sclerosis sine scleroderma manifested with gastrointestinal bleeding antiphospholipid syndrome and positive anti rna polymerase iii antibody case report and literature review |
| topic | systemic sclerosis sine scleroderma scleroderma systemic sclerosis angioectasia/ angiodysplasia. |
| url | https://www.dovepress.com/systemic-sclerosis-sine-scleroderma-manifested-with-gastrointestinal-b-peer-reviewed-article-IMCRJ |
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