Factorial Designs Help to Understand How Psychological Therapy Works
A large amount of research time and resources are spent trying to develop or improve psychological therapies. However, treatment development is challenging and time-consuming, and the typical research process followed—a series of standard randomized controlled trials—is inefficient and sub-optimal f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00429/full |
| _version_ | 1819077706772381696 |
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| author | Edward R. Watkins Alexandra Newbold |
| author_facet | Edward R. Watkins Alexandra Newbold |
| author_sort | Edward R. Watkins |
| collection | DOAJ |
| description | A large amount of research time and resources are spent trying to develop or improve psychological therapies. However, treatment development is challenging and time-consuming, and the typical research process followed—a series of standard randomized controlled trials—is inefficient and sub-optimal for answering many important clinical research questions. In other areas of health research, recognition of these challenges has led to the development of sophisticated designs tailored to increase research efficiency and answer more targeted research questions about treatment mechanisms or optimal delivery. However, these innovations have largely not permeated into psychological treatment development research. There is a recognition of the need to understand how treatments work and what their active ingredients might be, and a call for the use of innovative trial designs to support such discovery. One approach to unpack the active ingredients and mechanisms of therapy is the factorial design as exemplified in the Multiphase Optimization Strategy (MOST) approach. The MOST design allows identification of the active components of a complex multi-component intervention (such as CBT) using a sophisticated factorial design, allowing the development of more efficient interventions and elucidating their mechanisms of action. The rationale, design, and potential advantages of this approach will be illustrated with reference to the IMPROVE-2 study, which conducts a fractional factorial design to investigate which elements (e.g., thought challenging, activity scheduling, compassion, relaxation, concreteness, functional analysis) within therapist-supported internet-delivered CBT are most effective at reducing symptoms of depression in 767 adults with major depression. By using this innovative approach, we can first begin to work out what components within the overall treatment package are most efficacious on average allowing us to build an overall more streamlined and potent therapy. This approach also has potential to distinguish the role of specific versus non-specific common treatment components within treatment. |
| first_indexed | 2024-12-21T19:01:28Z |
| format | Article |
| id | doaj.art-664075ae92cc44819c96080208635231 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T19:01:28Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-664075ae92cc44819c960802086352312022-12-21T18:53:27ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-05-011110.3389/fpsyt.2020.00429477682Factorial Designs Help to Understand How Psychological Therapy WorksEdward R. WatkinsAlexandra NewboldA large amount of research time and resources are spent trying to develop or improve psychological therapies. However, treatment development is challenging and time-consuming, and the typical research process followed—a series of standard randomized controlled trials—is inefficient and sub-optimal for answering many important clinical research questions. In other areas of health research, recognition of these challenges has led to the development of sophisticated designs tailored to increase research efficiency and answer more targeted research questions about treatment mechanisms or optimal delivery. However, these innovations have largely not permeated into psychological treatment development research. There is a recognition of the need to understand how treatments work and what their active ingredients might be, and a call for the use of innovative trial designs to support such discovery. One approach to unpack the active ingredients and mechanisms of therapy is the factorial design as exemplified in the Multiphase Optimization Strategy (MOST) approach. The MOST design allows identification of the active components of a complex multi-component intervention (such as CBT) using a sophisticated factorial design, allowing the development of more efficient interventions and elucidating their mechanisms of action. The rationale, design, and potential advantages of this approach will be illustrated with reference to the IMPROVE-2 study, which conducts a fractional factorial design to investigate which elements (e.g., thought challenging, activity scheduling, compassion, relaxation, concreteness, functional analysis) within therapist-supported internet-delivered CBT are most effective at reducing symptoms of depression in 767 adults with major depression. By using this innovative approach, we can first begin to work out what components within the overall treatment package are most efficacious on average allowing us to build an overall more streamlined and potent therapy. This approach also has potential to distinguish the role of specific versus non-specific common treatment components within treatment.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00429/fullfactorialmechanismpsychotherapyspecific factorscommon factorscognitive behavioral therapy |
| spellingShingle | Edward R. Watkins Alexandra Newbold Factorial Designs Help to Understand How Psychological Therapy Works Frontiers in Psychiatry factorial mechanism psychotherapy specific factors common factors cognitive behavioral therapy |
| title | Factorial Designs Help to Understand How Psychological Therapy Works |
| title_full | Factorial Designs Help to Understand How Psychological Therapy Works |
| title_fullStr | Factorial Designs Help to Understand How Psychological Therapy Works |
| title_full_unstemmed | Factorial Designs Help to Understand How Psychological Therapy Works |
| title_short | Factorial Designs Help to Understand How Psychological Therapy Works |
| title_sort | factorial designs help to understand how psychological therapy works |
| topic | factorial mechanism psychotherapy specific factors common factors cognitive behavioral therapy |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00429/full |
| work_keys_str_mv | AT edwardrwatkins factorialdesignshelptounderstandhowpsychologicaltherapyworks AT alexandranewbold factorialdesignshelptounderstandhowpsychologicaltherapyworks |