Interferons—Implications in the Immune Response to Respiratory Viruses
Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/9/2179 |
| _version_ | 1797578736379363328 |
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| author | Harrison C. Bergeron Matthew R. Hansen Ralph A. Tripp |
| author_facet | Harrison C. Bergeron Matthew R. Hansen Ralph A. Tripp |
| author_sort | Harrison C. Bergeron |
| collection | DOAJ |
| description | Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease. |
| first_indexed | 2024-03-10T22:27:01Z |
| format | Article |
| id | doaj.art-6640885538a44f97a95a21b52f86acea |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T22:27:01Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-6640885538a44f97a95a21b52f86acea2023-11-19T12:01:40ZengMDPI AGMicroorganisms2076-26072023-08-01119217910.3390/microorganisms11092179Interferons—Implications in the Immune Response to Respiratory VirusesHarrison C. Bergeron0Matthew R. Hansen1Ralph A. Tripp2Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30605, USADepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30605, USADepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30605, USAInterferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease.https://www.mdpi.com/2076-2607/11/9/2179respiratory syncytial virusRSVinfluenzaSARS-CoV-2COVID-19interferons |
| spellingShingle | Harrison C. Bergeron Matthew R. Hansen Ralph A. Tripp Interferons—Implications in the Immune Response to Respiratory Viruses Microorganisms respiratory syncytial virus RSV influenza SARS-CoV-2 COVID-19 interferons |
| title | Interferons—Implications in the Immune Response to Respiratory Viruses |
| title_full | Interferons—Implications in the Immune Response to Respiratory Viruses |
| title_fullStr | Interferons—Implications in the Immune Response to Respiratory Viruses |
| title_full_unstemmed | Interferons—Implications in the Immune Response to Respiratory Viruses |
| title_short | Interferons—Implications in the Immune Response to Respiratory Viruses |
| title_sort | interferons implications in the immune response to respiratory viruses |
| topic | respiratory syncytial virus RSV influenza SARS-CoV-2 COVID-19 interferons |
| url | https://www.mdpi.com/2076-2607/11/9/2179 |
| work_keys_str_mv | AT harrisoncbergeron interferonsimplicationsintheimmuneresponsetorespiratoryviruses AT matthewrhansen interferonsimplicationsintheimmuneresponsetorespiratoryviruses AT ralphatripp interferonsimplicationsintheimmuneresponsetorespiratoryviruses |