Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India
Background: Pre-eclampsia is one of the major causes of maternal and fetal morbidity and mortality. Though the aetiology is obscure, recent studies indicate that serum levels of calcium and magnesium may have a role in pre-eclampsia. Aim: The aim of this study was to find out the relationship of...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-07-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4537/8872_CE(Ra1)_F(H)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
| Summary: | Background: Pre-eclampsia is one of the major causes of
maternal and fetal morbidity and mortality. Though the aetiology
is obscure, recent studies indicate that serum levels of calcium
and magnesium may have a role in pre-eclampsia.
Aim: The aim of this study was to find out the relationship of
serum levels of calcium and magnesium in pre-eclamptic
pregnancies compared to normal pregnancies in women from
southern coastal India.
Settings and Design: This study was done in a medical college
hospital in southern coastal India.
Materials and Methods: The blood samples from 60 preeclamptic women and an equal number of controls were analysed
for calcium and magnesium levels. Data on Body Mass Index,
maternal and gestational ages, serum calcium and magnesium
were compared between the two groups. Outcome of pregnancy
was analysed in both the groups and compared.
Statistical Analysis: Data was expressed as Mean ± Standard
Deviation. Data analysis was done by SPSS version 20.
Comparison of serum levels of the elements between the two
groups was performed by Independent t-test and Chi-square test
and P-value of < 0.05 was considered as statistically significant.
Results: The serum calcium concentration was significantly
lower in the pre-eclamptic group compared to normotensives
(7.84 ± 0.87 mg/dl Vs 8.97± 0.69 mg/dl, p<0.001) whereas the
levels of serum magnesium showed a marginal difference in both
the groups. (1.43± 0.55 mg/dl Vs, 1.57 ± 0.72 mg/dl P 0.257) The
study also showed that pre-eclamptic women were older, their
BMI was higher and birth weight of babies lower compared to
normotensives.
Conclusion: According to the results of our research, intake
of supplements, mainly calcium may help in the reduction
of incidence of pre-eclampsia especially in a population of a
developing country like ours where the nutrition is poor. Not many
studies have been done in developing countries to assess the role
of these elements in pre-eclampsia. The actual role of magnesium
and calcium supplements needs further investigation. |
|---|---|
| ISSN: | 2249-782X 0973-709X |