Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India
Background: Pre-eclampsia is one of the major causes of maternal and fetal morbidity and mortality. Though the aetiology is obscure, recent studies indicate that serum levels of calcium and magnesium may have a role in pre-eclampsia. Aim: The aim of this study was to find out the relationship of...
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JCDR Research and Publications Private Limited
2014-07-01
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| author | Deepa V Kanagal Aparna Rajesh Kavyarashmi Rao Ullal Harshini Devi Harish Shetty Sucheta Kumari Prasanna Kumar Shetty |
| author_facet | Deepa V Kanagal Aparna Rajesh Kavyarashmi Rao Ullal Harshini Devi Harish Shetty Sucheta Kumari Prasanna Kumar Shetty |
| author_sort | Deepa V Kanagal |
| collection | DOAJ |
| description | Background: Pre-eclampsia is one of the major causes of
maternal and fetal morbidity and mortality. Though the aetiology
is obscure, recent studies indicate that serum levels of calcium
and magnesium may have a role in pre-eclampsia.
Aim: The aim of this study was to find out the relationship of
serum levels of calcium and magnesium in pre-eclamptic
pregnancies compared to normal pregnancies in women from
southern coastal India.
Settings and Design: This study was done in a medical college
hospital in southern coastal India.
Materials and Methods: The blood samples from 60 preeclamptic women and an equal number of controls were analysed
for calcium and magnesium levels. Data on Body Mass Index,
maternal and gestational ages, serum calcium and magnesium
were compared between the two groups. Outcome of pregnancy
was analysed in both the groups and compared.
Statistical Analysis: Data was expressed as Mean ± Standard
Deviation. Data analysis was done by SPSS version 20.
Comparison of serum levels of the elements between the two
groups was performed by Independent t-test and Chi-square test
and P-value of < 0.05 was considered as statistically significant.
Results: The serum calcium concentration was significantly
lower in the pre-eclamptic group compared to normotensives
(7.84 ± 0.87 mg/dl Vs 8.97± 0.69 mg/dl, p<0.001) whereas the
levels of serum magnesium showed a marginal difference in both
the groups. (1.43± 0.55 mg/dl Vs, 1.57 ± 0.72 mg/dl P 0.257) The
study also showed that pre-eclamptic women were older, their
BMI was higher and birth weight of babies lower compared to
normotensives.
Conclusion: According to the results of our research, intake
of supplements, mainly calcium may help in the reduction
of incidence of pre-eclampsia especially in a population of a
developing country like ours where the nutrition is poor. Not many
studies have been done in developing countries to assess the role
of these elements in pre-eclampsia. The actual role of magnesium
and calcium supplements needs further investigation. |
| first_indexed | 2024-12-14T20:14:14Z |
| format | Article |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T20:14:14Z |
| publishDate | 2014-07-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-6641df0e17a745d7b611692f690212b82022-12-21T22:48:53ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-07-0187OC01OC0410.7860/JCDR/2014/8872.4537Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal IndiaDeepa V Kanagal0Aparna Rajesh1Kavyarashmi Rao2Ullal Harshini Devi3Harish Shetty4Sucheta Kumari5Prasanna Kumar Shetty6Associate Professor, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Associate Professor, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Post Graduate, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Research Assistant, Department of Biochemistry, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Professor and HOD, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Professor, Department of Biochemistry, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Professor, Department of Obstetrics and Gynaecology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.Background: Pre-eclampsia is one of the major causes of maternal and fetal morbidity and mortality. Though the aetiology is obscure, recent studies indicate that serum levels of calcium and magnesium may have a role in pre-eclampsia. Aim: The aim of this study was to find out the relationship of serum levels of calcium and magnesium in pre-eclamptic pregnancies compared to normal pregnancies in women from southern coastal India. Settings and Design: This study was done in a medical college hospital in southern coastal India. Materials and Methods: The blood samples from 60 preeclamptic women and an equal number of controls were analysed for calcium and magnesium levels. Data on Body Mass Index, maternal and gestational ages, serum calcium and magnesium were compared between the two groups. Outcome of pregnancy was analysed in both the groups and compared. Statistical Analysis: Data was expressed as Mean ± Standard Deviation. Data analysis was done by SPSS version 20. Comparison of serum levels of the elements between the two groups was performed by Independent t-test and Chi-square test and P-value of < 0.05 was considered as statistically significant. Results: The serum calcium concentration was significantly lower in the pre-eclamptic group compared to normotensives (7.84 ± 0.87 mg/dl Vs 8.97± 0.69 mg/dl, p<0.001) whereas the levels of serum magnesium showed a marginal difference in both the groups. (1.43± 0.55 mg/dl Vs, 1.57 ± 0.72 mg/dl P 0.257) The study also showed that pre-eclamptic women were older, their BMI was higher and birth weight of babies lower compared to normotensives. Conclusion: According to the results of our research, intake of supplements, mainly calcium may help in the reduction of incidence of pre-eclampsia especially in a population of a developing country like ours where the nutrition is poor. Not many studies have been done in developing countries to assess the role of these elements in pre-eclampsia. The actual role of magnesium and calcium supplements needs further investigation.https://jcdr.net/articles/PDF/4537/8872_CE(Ra1)_F(H)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdfcalciummagnesiumnutritionpre-eclampsia |
| spellingShingle | Deepa V Kanagal Aparna Rajesh Kavyarashmi Rao Ullal Harshini Devi Harish Shetty Sucheta Kumari Prasanna Kumar Shetty Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India Journal of Clinical and Diagnostic Research calcium magnesium nutrition pre-eclampsia |
| title | Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India |
| title_full | Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India |
| title_fullStr | Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India |
| title_full_unstemmed | Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India |
| title_short | Levels of Serum Calcium and Magnesium in Pre-eclamptic and Normal Pregnancy: A Study from Coastal India |
| title_sort | levels of serum calcium and magnesium in pre eclamptic and normal pregnancy a study from coastal india |
| topic | calcium magnesium nutrition pre-eclampsia |
| url | https://jcdr.net/articles/PDF/4537/8872_CE(Ra1)_F(H)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
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