Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success
Several congenital disorders can cause end stage bladder disease and possibly renal damage in children. The current gold standard therapy is enterocystoplasty, a bladder augmentation using an intestinal segment. However, the use of bowel tissue is associated with numerous complications such as metab...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00091/full |
| _version_ | 1819211276695371776 |
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| author | Maya Horst Maya Horst Daniel Eberli Rita Gobet Souzan Salemi |
| author_facet | Maya Horst Maya Horst Daniel Eberli Rita Gobet Souzan Salemi |
| author_sort | Maya Horst |
| collection | DOAJ |
| description | Several congenital disorders can cause end stage bladder disease and possibly renal damage in children. The current gold standard therapy is enterocystoplasty, a bladder augmentation using an intestinal segment. However, the use of bowel tissue is associated with numerous complications such as metabolic disturbance, stone formation, urine leakage, chronic infections, and malignancy. Urinary diversions using engineered bladder tissue would obviate the need for bowel for bladder reconstruction. Despite impressive progress in the field of bladder tissue engineering over the past decades, the successful transfer of the approach into clinical routine still represents a major challenge. In this review, we discuss major achievements and challenges in bladder tissue regeneration with a focus on different strategies to overcome the obstacles and to meet the need for living functional tissue replacements with a good growth potential and a long life span matching the pediatric population. |
| first_indexed | 2024-12-23T06:24:30Z |
| format | Article |
| id | doaj.art-6646420b67d445168d7871a486fa7ba3 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-23T06:24:30Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6646420b67d445168d7871a486fa7ba32022-12-21T17:57:07ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-03-01710.3389/fped.2019.00091443227Tissue Engineering in Pediatric Bladder Reconstruction—The Road to SuccessMaya Horst0Maya Horst1Daniel Eberli2Rita Gobet3Souzan Salemi4Laboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital, Zurich, SwitzerlandDivision of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital, Zurich, SwitzerlandDivision of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital, Zurich, SwitzerlandLaboratory for Urologic Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital, Zurich, SwitzerlandDivision of Pediatric Urology, Department of Pediatric Surgery, University Children‘s Hospital, Zurich, SwitzerlandSeveral congenital disorders can cause end stage bladder disease and possibly renal damage in children. The current gold standard therapy is enterocystoplasty, a bladder augmentation using an intestinal segment. However, the use of bowel tissue is associated with numerous complications such as metabolic disturbance, stone formation, urine leakage, chronic infections, and malignancy. Urinary diversions using engineered bladder tissue would obviate the need for bowel for bladder reconstruction. Despite impressive progress in the field of bladder tissue engineering over the past decades, the successful transfer of the approach into clinical routine still represents a major challenge. In this review, we discuss major achievements and challenges in bladder tissue regeneration with a focus on different strategies to overcome the obstacles and to meet the need for living functional tissue replacements with a good growth potential and a long life span matching the pediatric population.https://www.frontiersin.org/article/10.3389/fped.2019.00091/fullmyelomeningoceleneurogenic bladderbladder augmentationtissue engineeringstem cellspediatric |
| spellingShingle | Maya Horst Maya Horst Daniel Eberli Rita Gobet Souzan Salemi Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success Frontiers in Pediatrics myelomeningocele neurogenic bladder bladder augmentation tissue engineering stem cells pediatric |
| title | Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success |
| title_full | Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success |
| title_fullStr | Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success |
| title_full_unstemmed | Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success |
| title_short | Tissue Engineering in Pediatric Bladder Reconstruction—The Road to Success |
| title_sort | tissue engineering in pediatric bladder reconstruction the road to success |
| topic | myelomeningocele neurogenic bladder bladder augmentation tissue engineering stem cells pediatric |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00091/full |
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