Molecule gated mesoporous silica for on-command drug delivery: A review
The development of nanomedicine is increasing significantly nowadays due to its effectless and efficiency than before. One recent nanomedicine innovation is molecule gates material mesoporous silica that supports drug delivery systems. The gates could be opened or closed in response to an external o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623002928 |
| _version_ | 1797398624649347072 |
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| author | Muhson Isroni Fuja Sagita Neng T.U. Culsum Grandprix T.M. Kadja |
| author_facet | Muhson Isroni Fuja Sagita Neng T.U. Culsum Grandprix T.M. Kadja |
| author_sort | Muhson Isroni |
| collection | DOAJ |
| description | The development of nanomedicine is increasing significantly nowadays due to its effectless and efficiency than before. One recent nanomedicine innovation is molecule gates material mesoporous silica that supports drug delivery systems. The gates could be opened or closed in response to an external or internal command or stimulus. The internal stimulus consists of pH, redox, and enzymes. In contrast, the external stimulus consists of light and thermal stimuli. The gates can respond to the stimulus. As a result, the drug will be released. To modify nano gates, the materials and the drug are crucial for the design and functionality of these systems and can be effective in achieving the goal. This review explains the molecule-gated mesoporous silica nanomaterial (MSNs), the mechanism of internal/external stimulus of the nano gates in drug delivery systems (DDS), the potential and the biocompatibility of mesoporous silica nanomaterial (MSNs) as a nano gate and the pathways or methods to modified them. |
| first_indexed | 2024-03-09T01:28:15Z |
| format | Article |
| id | doaj.art-66477017345040afa4fff72d6c4a6692 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T01:28:15Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-66477017345040afa4fff72d6c4a66922023-12-10T06:15:04ZengElsevierResults in Chemistry2211-71562023-12-016101053Molecule gated mesoporous silica for on-command drug delivery: A reviewMuhson Isroni0Fuja Sagita1Neng T.U. Culsum2Grandprix T.M. Kadja3Research Center for Applied Microbiology, National Research and Innovation Agency of Indonesia (BRIN), KST Soekarno, Jl. Raya Jakarta-Bogor KM 46, Cibinong 16911, Jawa Barat, IndonesiaDivision of Inorganic and Physical Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132, IndonesiaDivision of Inorganic and Physical Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132, IndonesiaDivision of Inorganic and Physical Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132, Indonesia; Research Center for Nanosciences and Nanotechnology, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132, Indonesia; Corresponding author at: Division of Inorganic and Physical Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha no. 10, Bandung 40132, Indonesia.The development of nanomedicine is increasing significantly nowadays due to its effectless and efficiency than before. One recent nanomedicine innovation is molecule gates material mesoporous silica that supports drug delivery systems. The gates could be opened or closed in response to an external or internal command or stimulus. The internal stimulus consists of pH, redox, and enzymes. In contrast, the external stimulus consists of light and thermal stimuli. The gates can respond to the stimulus. As a result, the drug will be released. To modify nano gates, the materials and the drug are crucial for the design and functionality of these systems and can be effective in achieving the goal. This review explains the molecule-gated mesoporous silica nanomaterial (MSNs), the mechanism of internal/external stimulus of the nano gates in drug delivery systems (DDS), the potential and the biocompatibility of mesoporous silica nanomaterial (MSNs) as a nano gate and the pathways or methods to modified them.http://www.sciencedirect.com/science/article/pii/S2211715623002928Drug deliveryMesoporous silicaMolecule gate |
| spellingShingle | Muhson Isroni Fuja Sagita Neng T.U. Culsum Grandprix T.M. Kadja Molecule gated mesoporous silica for on-command drug delivery: A review Results in Chemistry Drug delivery Mesoporous silica Molecule gate |
| title | Molecule gated mesoporous silica for on-command drug delivery: A review |
| title_full | Molecule gated mesoporous silica for on-command drug delivery: A review |
| title_fullStr | Molecule gated mesoporous silica for on-command drug delivery: A review |
| title_full_unstemmed | Molecule gated mesoporous silica for on-command drug delivery: A review |
| title_short | Molecule gated mesoporous silica for on-command drug delivery: A review |
| title_sort | molecule gated mesoporous silica for on command drug delivery a review |
| topic | Drug delivery Mesoporous silica Molecule gate |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623002928 |
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