Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division. Within the cell, MTs are not uniform as they can be composed of different tubulin isotypes that are post-translational...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/16/3705 |
| _version_ | 1797558148964286464 |
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| author | Filip Borys Ewa Joachimiak Hanna Krawczyk Hanna Fabczak |
| author_facet | Filip Borys Ewa Joachimiak Hanna Krawczyk Hanna Fabczak |
| author_sort | Filip Borys |
| collection | DOAJ |
| description | Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division. Within the cell, MTs are not uniform as they can be composed of different tubulin isotypes that are post-translationally modified and interact with different microtubule-associated proteins (MAPs). These diverse intrinsic factors influence the dynamics of MTs. Extrinsic factors such as microtubule-targeting agents (MTAs) can also affect MT dynamics. MTAs can be divided into two main categories: microtubule-stabilizing agents (MSAs) and microtubule-destabilizing agents (MDAs). Thus, the MT skeleton is an important target for anticancer therapy. This review discusses factors that determine the microtubule dynamics in normal and cancer cells and describes microtubule–MTA interactions, highlighting the importance of tubulin isoform diversity and post-translational modifications in MTA responses and the consequences of such a phenomenon, including drug resistance development. |
| first_indexed | 2024-03-10T17:27:24Z |
| format | Article |
| id | doaj.art-6648dda9fa38449aa931f33fdf2d9000 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:27:24Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6648dda9fa38449aa931f33fdf2d90002023-11-20T10:08:29ZengMDPI AGMolecules1420-30492020-08-012516370510.3390/molecules25163705Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer CellsFilip Borys0Ewa Joachimiak1Hanna Krawczyk2Hanna Fabczak3Laboratory of Cytoskeleton and Cilia Biology Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, PolandLaboratory of Cytoskeleton and Cilia Biology Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, PolandDepartment of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, 3 Noakowskiego Street, 00-664 Warsaw, PolandLaboratory of Cytoskeleton and Cilia Biology Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, PolandMicrotubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division. Within the cell, MTs are not uniform as they can be composed of different tubulin isotypes that are post-translationally modified and interact with different microtubule-associated proteins (MAPs). These diverse intrinsic factors influence the dynamics of MTs. Extrinsic factors such as microtubule-targeting agents (MTAs) can also affect MT dynamics. MTAs can be divided into two main categories: microtubule-stabilizing agents (MSAs) and microtubule-destabilizing agents (MDAs). Thus, the MT skeleton is an important target for anticancer therapy. This review discusses factors that determine the microtubule dynamics in normal and cancer cells and describes microtubule–MTA interactions, highlighting the importance of tubulin isoform diversity and post-translational modifications in MTA responses and the consequences of such a phenomenon, including drug resistance development.https://www.mdpi.com/1420-3049/25/16/3705α-tubulinβ-tubulinmicrotubulepost-translational modificationscancermicrotubule-targeting agents (MTAs) |
| spellingShingle | Filip Borys Ewa Joachimiak Hanna Krawczyk Hanna Fabczak Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells Molecules α-tubulin β-tubulin microtubule post-translational modifications cancer microtubule-targeting agents (MTAs) |
| title | Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells |
| title_full | Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells |
| title_fullStr | Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells |
| title_full_unstemmed | Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells |
| title_short | Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells |
| title_sort | intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells |
| topic | α-tubulin β-tubulin microtubule post-translational modifications cancer microtubule-targeting agents (MTAs) |
| url | https://www.mdpi.com/1420-3049/25/16/3705 |
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