Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms
Objective:Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations.Methods:The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-03-01
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| Series: | Bezmiâlem Science |
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| Online Access: |
http://bezmialemscience.org/archives/archive-detail/article-preview/spectrophotometric-determination-of-erdosteine-at-/43877
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| _version_ | 1797912509065199616 |
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| author | Cem ÖNAL Demet DİNÇEL |
| author_facet | Cem ÖNAL Demet DİNÇEL |
| author_sort | Cem ÖNAL |
| collection | DOAJ |
| description | Objective:Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations.Methods:The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated.Results:Beer’s plots were obeyed in a general concentration range of 10-500 μg mL-1 and 20-600 μg mL-1 for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated.Conclusion:The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method. |
| first_indexed | 2024-04-10T11:58:13Z |
| format | Article |
| id | doaj.art-6649041fffa74b368dd38bbed33d3490 |
| institution | Directory Open Access Journal |
| issn | 2148-2373 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T11:58:13Z |
| publishDate | 2021-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-6649041fffa74b368dd38bbed33d34902023-02-15T16:16:45ZengGalenos Publishing HouseBezmiâlem Science2148-23732148-23732021-03-0191202410.14235/bas.galenos.2020.391613049054Spectrophotometric Determination of Erdosteine at Capsule Dosage FormsCem ÖNAL0Demet DİNÇEL1 Cinnagen Medicine Company, Project Director, İstanbul, Turkey Bezmialem Vakıf University Faculty of Pharmacy, Department of Analytical Chemistry, İstanbul, Turkey Objective:Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations.Methods:The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated.Results:Beer’s plots were obeyed in a general concentration range of 10-500 μg mL-1 and 20-600 μg mL-1 for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated.Conclusion:The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method. http://bezmialemscience.org/archives/archive-detail/article-preview/spectrophotometric-determination-of-erdosteine-at-/43877 erdosteinecharge transfer complextcnqcaspectrophotometryvalidationpharmaceutical formulation |
| spellingShingle | Cem ÖNAL Demet DİNÇEL Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms Bezmiâlem Science erdosteine charge transfer complex tcnq ca spectrophotometry validation pharmaceutical formulation |
| title | Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms |
| title_full | Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms |
| title_fullStr | Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms |
| title_full_unstemmed | Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms |
| title_short | Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms |
| title_sort | spectrophotometric determination of erdosteine at capsule dosage forms |
| topic | erdosteine charge transfer complex tcnq ca spectrophotometry validation pharmaceutical formulation |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/spectrophotometric-determination-of-erdosteine-at-/43877
|
| work_keys_str_mv | AT cemonal spectrophotometricdeterminationoferdosteineatcapsuledosageforms AT demetdincel spectrophotometricdeterminationoferdosteineatcapsuledosageforms |