Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study

Objective: Understanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies. Methods: Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the glob...

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Main Authors: Yuxia Du, Rui Yan, Xiaoyue Wu, Xiaobao Zhang, Can Chen, Daixi Jiang, Mengya Yang, Kexin Cao, Mengsha Chen, Yue You, Wenkai Zhou, Dingmo Chen, Gang Xu, Shigui Yang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:International Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971223006938
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author Yuxia Du
Rui Yan
Xiaoyue Wu
Xiaobao Zhang
Can Chen
Daixi Jiang
Mengya Yang
Kexin Cao
Mengsha Chen
Yue You
Wenkai Zhou
Dingmo Chen
Gang Xu
Shigui Yang
author_facet Yuxia Du
Rui Yan
Xiaoyue Wu
Xiaobao Zhang
Can Chen
Daixi Jiang
Mengya Yang
Kexin Cao
Mengsha Chen
Yue You
Wenkai Zhou
Dingmo Chen
Gang Xu
Shigui Yang
author_sort Yuxia Du
collection DOAJ
description Objective: Understanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies. Methods: Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the global temporal trends of RSV and further stratified analyses were conducted according to the Socio-demographic Index (SDI), which is a composite measure of income, education, and total fertility. Age-period-cohort model was used to evaluate age, period, and cohort effects. Results: In 2019, the global age-standardized rate of mortality (ASMR) and disability-adjusted life years (ASR-DALYs) of RSV were 4.79/100,000 (95% uncertainty interval [95% UI]: 1.82/100,000-9.32/100,000) and 218.34/100,000 (95% UI: 92.06/100,000-376.80/100,000), respectively. The burden of RSV was higher in men than women. The highest ASMR (10.26/100,000, 3.80/100,000-20.16/100,000) and ASR-DALYs (478.71/100,000, 202.40/100,000-840.85/100,000) were reported in low-SDI region. Although mortality and DALYs rates in all age groups declined globally, the pace of decline was not uniform across age groups. Mortality rate in the elderly over 70 years surpassed that in children under 5 years in 2019. Conclusion: This study highlights the need for targeted interventions to reduce the burden of RSV, particularly in low-SDI region, and among the elderly over 70 years.
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spelling doaj.art-66496736276f446f99050837b74b0a6a2023-09-26T04:12:04ZengElsevierInternational Journal of Infectious Diseases1201-97122023-10-011357076Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 StudyYuxia Du0Rui Yan1Xiaoyue Wu2Xiaobao Zhang3Can Chen4Daixi Jiang5Mengya Yang6Kexin Cao7Mengsha Chen8Yue You9Wenkai Zhou10Dingmo Chen11Gang Xu12Shigui Yang13Department of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Emergency Medicine, Second Affiliated Hospital, Department of Public Health, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author: Tel.: 13605705640.Objective: Understanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies. Methods: Data on RSV-related burden were extracted from the Global Burden of Disease 2019. Joinpoint regression models were used to assess the global temporal trends of RSV and further stratified analyses were conducted according to the Socio-demographic Index (SDI), which is a composite measure of income, education, and total fertility. Age-period-cohort model was used to evaluate age, period, and cohort effects. Results: In 2019, the global age-standardized rate of mortality (ASMR) and disability-adjusted life years (ASR-DALYs) of RSV were 4.79/100,000 (95% uncertainty interval [95% UI]: 1.82/100,000-9.32/100,000) and 218.34/100,000 (95% UI: 92.06/100,000-376.80/100,000), respectively. The burden of RSV was higher in men than women. The highest ASMR (10.26/100,000, 3.80/100,000-20.16/100,000) and ASR-DALYs (478.71/100,000, 202.40/100,000-840.85/100,000) were reported in low-SDI region. Although mortality and DALYs rates in all age groups declined globally, the pace of decline was not uniform across age groups. Mortality rate in the elderly over 70 years surpassed that in children under 5 years in 2019. Conclusion: This study highlights the need for targeted interventions to reduce the burden of RSV, particularly in low-SDI region, and among the elderly over 70 years.http://www.sciencedirect.com/science/article/pii/S1201971223006938Respiratory syncytial virusEpidemiologic characteristicsAge-period-cohort modelTrends
spellingShingle Yuxia Du
Rui Yan
Xiaoyue Wu
Xiaobao Zhang
Can Chen
Daixi Jiang
Mengya Yang
Kexin Cao
Mengsha Chen
Yue You
Wenkai Zhou
Dingmo Chen
Gang Xu
Shigui Yang
Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
International Journal of Infectious Diseases
Respiratory syncytial virus
Epidemiologic characteristics
Age-period-cohort model
Trends
title Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
title_full Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
title_fullStr Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
title_full_unstemmed Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
title_short Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study
title_sort global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019 a systematic analysis of the global burden of disease 2019 study
topic Respiratory syncytial virus
Epidemiologic characteristics
Age-period-cohort model
Trends
url http://www.sciencedirect.com/science/article/pii/S1201971223006938
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