Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis
Background/Objectives: More elderly patients with end-stage liver disease are receiving liver transplantation. However, data on outcome of recipients older than 70 years are still limited. The current systematic review and meta-analysis was conducted with the aim to better describe the survival outc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Transplantation |
| Subjects: | |
| Online Access: | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2020;volume=14;issue=1;spage=63;epage=67;aulast=Wijarnpreecha |
| _version_ | 1818118524329000960 |
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| author | Karn Wijarnpreecha Panadeekarn Panjawatanan Omar Y Mousa Wisit Cheungpasitporn Frank J Lukens Justin H Nguyen Surakit Pungpapong Denise M Harnois Patompong Ungprasert |
| author_facet | Karn Wijarnpreecha Panadeekarn Panjawatanan Omar Y Mousa Wisit Cheungpasitporn Frank J Lukens Justin H Nguyen Surakit Pungpapong Denise M Harnois Patompong Ungprasert |
| author_sort | Karn Wijarnpreecha |
| collection | DOAJ |
| description | Background/Objectives: More elderly patients with end-stage liver disease are receiving liver transplantation. However, data on outcome of recipients older than 70 years are still limited. The current systematic review and meta-analysis was conducted with the aim to better describe the survival outcome of liver transplant in recipients older than 70 years compared to younger recipients. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through March 2019 to identify all cohort studies that compared the long-term survival outcome between patients who underwent liver transplantation at age of >70 years versus younger recipients. Effect estimates from each study were extracted and combined together using the random-effects, generic inverse variance method of DerSimonian and Laird. Results: A total of 5 studies with 19,757 participants fulfilled the eligibility criteria and were included in the meta-analysis. The mortality rate was significantly increased among recipients who were 70 years or older compared to younger recipients with the pooled hazard ratio of 1.72 (95% confidence interval: 1.43–2.06; I2: 16%). Conclusions: The current study demonstrated a significantly increased risk of mortality postliver transplantation among recipients older than 70 years. This could be useful information to be considered along with other factors to establish graft allocation policy. |
| first_indexed | 2024-12-11T04:55:40Z |
| format | Article |
| id | doaj.art-664b01e8464742bca4db5430bdaaacc5 |
| institution | Directory Open Access Journal |
| issn | 2212-0017 2212-0025 |
| language | English |
| last_indexed | 2024-12-11T04:55:40Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj.art-664b01e8464742bca4db5430bdaaacc52022-12-22T01:20:17ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252020-01-01141636710.4103/ijot.ijot_59_19Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysisKarn WijarnpreechaPanadeekarn PanjawatananOmar Y MousaWisit CheungpasitpornFrank J LukensJustin H NguyenSurakit PungpapongDenise M HarnoisPatompong UngprasertBackground/Objectives: More elderly patients with end-stage liver disease are receiving liver transplantation. However, data on outcome of recipients older than 70 years are still limited. The current systematic review and meta-analysis was conducted with the aim to better describe the survival outcome of liver transplant in recipients older than 70 years compared to younger recipients. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through March 2019 to identify all cohort studies that compared the long-term survival outcome between patients who underwent liver transplantation at age of >70 years versus younger recipients. Effect estimates from each study were extracted and combined together using the random-effects, generic inverse variance method of DerSimonian and Laird. Results: A total of 5 studies with 19,757 participants fulfilled the eligibility criteria and were included in the meta-analysis. The mortality rate was significantly increased among recipients who were 70 years or older compared to younger recipients with the pooled hazard ratio of 1.72 (95% confidence interval: 1.43–2.06; I2: 16%). Conclusions: The current study demonstrated a significantly increased risk of mortality postliver transplantation among recipients older than 70 years. This could be useful information to be considered along with other factors to establish graft allocation policy.http://www.ijtonline.in/article.asp?issn=2212-0017;year=2020;volume=14;issue=1;spage=63;epage=67;aulast=Wijarnpreechaliver transplantmeta-analysisoutcomeseptuagenariansurvival |
| spellingShingle | Karn Wijarnpreecha Panadeekarn Panjawatanan Omar Y Mousa Wisit Cheungpasitporn Frank J Lukens Justin H Nguyen Surakit Pungpapong Denise M Harnois Patompong Ungprasert Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis Indian Journal of Transplantation liver transplant meta-analysis outcome septuagenarian survival |
| title | Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis |
| title_full | Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis |
| title_fullStr | Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis |
| title_full_unstemmed | Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis |
| title_short | Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis |
| title_sort | survival after liver transplant in recipients older than 70 years a systematic review and meta analysis |
| topic | liver transplant meta-analysis outcome septuagenarian survival |
| url | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2020;volume=14;issue=1;spage=63;epage=67;aulast=Wijarnpreecha |
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