Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis
Background: Colorectal cancer (CRC) is known to be affected by paraneoplastic thrombocytosis and chromogranin A-positive neuroendocrine-cell differentiation (CgA<sup>+</sup>). Their combined effect has never been previously investigated. Methods: A prospective cohort pilot study of 42 CR...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/1/67 |
| _version_ | 1797543227154235392 |
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| author | Zoltan Herold Magdolna Dank Magdolna Herold Peter Nagy Klara Rosta Aniko Somogyi |
| author_facet | Zoltan Herold Magdolna Dank Magdolna Herold Peter Nagy Klara Rosta Aniko Somogyi |
| author_sort | Zoltan Herold |
| collection | DOAJ |
| description | Background: Colorectal cancer (CRC) is known to be affected by paraneoplastic thrombocytosis and chromogranin A-positive neuroendocrine-cell differentiation (CgA<sup>+</sup>). Their combined effect has never been previously investigated. Methods: A prospective cohort pilot study of 42 CRC patients and 42 age- and sex-matched controls was carried out. Plasma interleukin-6, thrombopoietin, and serum chromogranin A and -B were measured; furthermore, tumor tissue was immunohistochemically stained for CgA<sup>+</sup>. Results: Twenty-seven and 15 patients were assigned to the chromogranin A-negative (CgA<sup>−</sup>) and CgA<sup>+</sup> groups, respectively. Within the CgA<sup>+</sup> group, right-sided tumors were more frequent (18.5% vs. 53.3%), no stage I cancer was found, and patients of this group were in worse general condition. Compared to control subjects, chromogranin A level was higher in the CgA<sup>+</sup> group (<i>p</i> = 0.0086), thrombopoietin (<i>p</i> = 0.0040) and chromogranin B (<i>p</i> = 0.0070) in the CgA<sup>−</sup> group, while interleukin-6 was high in both tumor groups (<i>p</i> ≤ 0.0090). Survival was significantly worse in the CgA<sup>+</sup> group (hazard ratio: 5.73; <i>p</i> = 0.0378). Conclusions: Different thrombopoietin levels indicated distinct thrombocytosis types. Within the two CRC groups, serum levels of chromogranins changed in different directions suggesting two well-distinguishable pathophysiologies. Based on these observations we propose a new subtype of CRC, which can be characterized by chromogranin A-positive neuroendocrine-cell differentiation. |
| first_indexed | 2024-03-10T13:41:38Z |
| format | Article |
| id | doaj.art-664be40070754c1ca7fda82bd289dc72 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:41:38Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-664be40070754c1ca7fda82bd289dc722023-11-21T02:56:57ZengMDPI AGCancers2072-66942020-12-011316710.3390/cancers13010067Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse PrognosisZoltan Herold0Magdolna Dank1Magdolna Herold2Peter Nagy3Klara Rosta4Aniko Somogyi5Department of Internal Medicine and Oncology, Semmelweis University, Tomo u. 25-29., H-1083 Budapest, HungaryDepartment of Internal Medicine and Oncology, Semmelweis University, Tomo u. 25-29., H-1083 Budapest, HungaryDepartment of Internal Medicine and Hematology, Semmelweis University, Szentkiralyi u. 46., H-1088 Budapest, Hungary1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26., H-1085 Budapest, HungaryDepartment of Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel 18-20, A-1090 Vienna, AustriaDepartment of Internal Medicine and Hematology, Semmelweis University, Szentkiralyi u. 46., H-1088 Budapest, HungaryBackground: Colorectal cancer (CRC) is known to be affected by paraneoplastic thrombocytosis and chromogranin A-positive neuroendocrine-cell differentiation (CgA<sup>+</sup>). Their combined effect has never been previously investigated. Methods: A prospective cohort pilot study of 42 CRC patients and 42 age- and sex-matched controls was carried out. Plasma interleukin-6, thrombopoietin, and serum chromogranin A and -B were measured; furthermore, tumor tissue was immunohistochemically stained for CgA<sup>+</sup>. Results: Twenty-seven and 15 patients were assigned to the chromogranin A-negative (CgA<sup>−</sup>) and CgA<sup>+</sup> groups, respectively. Within the CgA<sup>+</sup> group, right-sided tumors were more frequent (18.5% vs. 53.3%), no stage I cancer was found, and patients of this group were in worse general condition. Compared to control subjects, chromogranin A level was higher in the CgA<sup>+</sup> group (<i>p</i> = 0.0086), thrombopoietin (<i>p</i> = 0.0040) and chromogranin B (<i>p</i> = 0.0070) in the CgA<sup>−</sup> group, while interleukin-6 was high in both tumor groups (<i>p</i> ≤ 0.0090). Survival was significantly worse in the CgA<sup>+</sup> group (hazard ratio: 5.73; <i>p</i> = 0.0378). Conclusions: Different thrombopoietin levels indicated distinct thrombocytosis types. Within the two CRC groups, serum levels of chromogranins changed in different directions suggesting two well-distinguishable pathophysiologies. Based on these observations we propose a new subtype of CRC, which can be characterized by chromogranin A-positive neuroendocrine-cell differentiation.https://www.mdpi.com/2072-6694/13/1/67chromogranin Achromogranin Bcolorectal neoplasmsinterleukin-6neuroendocrine cellssurvival analysis |
| spellingShingle | Zoltan Herold Magdolna Dank Magdolna Herold Peter Nagy Klara Rosta Aniko Somogyi Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis Cancers chromogranin A chromogranin B colorectal neoplasms interleukin-6 neuroendocrine cells survival analysis |
| title | Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis |
| title_full | Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis |
| title_fullStr | Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis |
| title_full_unstemmed | Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis |
| title_short | Histopathological Chromogranin A-Positivity Is Associated with Right-Sided Colorectal Cancers and Worse Prognosis |
| title_sort | histopathological chromogranin a positivity is associated with right sided colorectal cancers and worse prognosis |
| topic | chromogranin A chromogranin B colorectal neoplasms interleukin-6 neuroendocrine cells survival analysis |
| url | https://www.mdpi.com/2072-6694/13/1/67 |
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