Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis
BackgroundOverweight and obesity are considered as one of the major risk factors for cardiovascular diseases (CVD). At present, many studies have proved that multiple nutritional supplements play an active role in metabolic diseases. However, the comparative efficacy of different nutritional supplem...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1140019/full |
| _version_ | 1797856213201846272 |
|---|---|
| author | Zengli Yu Danyang Zhao Xinxin Liu |
| author_facet | Zengli Yu Danyang Zhao Xinxin Liu |
| author_sort | Zengli Yu |
| collection | DOAJ |
| description | BackgroundOverweight and obesity are considered as one of the major risk factors for cardiovascular diseases (CVD). At present, many studies have proved that multiple nutritional supplements play an active role in metabolic diseases. However, the comparative efficacy of different nutritional supplements in improving indicators of cardiometabolic risk in obese and overweight patients is uncertain.MethodsCochrane Library, PubMed, Embase, and Web of Science were searched for the period from January 1990 to March 2022. A random-effect model was built in the Bayesian network meta-analysis. The surface under the cumulative ranking analysis (SUCRA) and clustering rank analysis was performed for ranking the effects.ResultsThe study included 65 RCTs with 4,241 patients. In terms of glucose control, probiotic was more conductive to improve FBG (MD: −0.90; 95%CrI: −1.41 to −0.38), FINS (MD: −2.05; 95%CrI: −4.27 to −0.02), HOMA-IR (MD: −2.59; 95%CI −3.42 to −1.76). Probiotic (MD: −11.15, 95%CrI −22.16 to −1.26), omega-3 (MD: −9.45; 95%CrI: −20.69 to −0.93), VD (MD: −17.86; 95%CrI: −35.53 to −0.27), and probiotic +omega-3 (MD: 5.24; 95%CrI: 0.78 to 9.63) were beneficial to the improvement of TGs, TC and HDL-C, respectively. The SUCRA revealed that probiotic might be the best intervention to reduce FBG, FINS, HOMA-IR; Simultaneously, α-lipoic acid, VD, and probiotic + omega-3 might be the best intervention to improve TGs, TC, and HDL-C, respectively. Cluster-rank results revealed probiotic had the best comprehensive improvement effect on glucose metabolism, and probiotic + omega-3 may have a better comprehensive improvement effect on lipid metabolism (cluster-rank value for FBG and FINS: 3290.50 and for TGs and HDL-C: 2117.61).ConclusionNutritional supplementation is effective on CVD risk factors in overweight and obese patients. Probiotic supplementation might be the best intervention for blood glucose control; VD, probiotic + omega-3 have a better impact on improving lipid metabolism. Further studies are required to verify the current findings. |
| first_indexed | 2024-04-09T20:36:45Z |
| format | Article |
| id | doaj.art-664d683ca5e34a11b55033a550413753 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T20:36:45Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-664d683ca5e34a11b55033a5504137532023-03-30T08:03:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11400191140019Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysisZengli YuDanyang ZhaoXinxin LiuBackgroundOverweight and obesity are considered as one of the major risk factors for cardiovascular diseases (CVD). At present, many studies have proved that multiple nutritional supplements play an active role in metabolic diseases. However, the comparative efficacy of different nutritional supplements in improving indicators of cardiometabolic risk in obese and overweight patients is uncertain.MethodsCochrane Library, PubMed, Embase, and Web of Science were searched for the period from January 1990 to March 2022. A random-effect model was built in the Bayesian network meta-analysis. The surface under the cumulative ranking analysis (SUCRA) and clustering rank analysis was performed for ranking the effects.ResultsThe study included 65 RCTs with 4,241 patients. In terms of glucose control, probiotic was more conductive to improve FBG (MD: −0.90; 95%CrI: −1.41 to −0.38), FINS (MD: −2.05; 95%CrI: −4.27 to −0.02), HOMA-IR (MD: −2.59; 95%CI −3.42 to −1.76). Probiotic (MD: −11.15, 95%CrI −22.16 to −1.26), omega-3 (MD: −9.45; 95%CrI: −20.69 to −0.93), VD (MD: −17.86; 95%CrI: −35.53 to −0.27), and probiotic +omega-3 (MD: 5.24; 95%CrI: 0.78 to 9.63) were beneficial to the improvement of TGs, TC and HDL-C, respectively. The SUCRA revealed that probiotic might be the best intervention to reduce FBG, FINS, HOMA-IR; Simultaneously, α-lipoic acid, VD, and probiotic + omega-3 might be the best intervention to improve TGs, TC, and HDL-C, respectively. Cluster-rank results revealed probiotic had the best comprehensive improvement effect on glucose metabolism, and probiotic + omega-3 may have a better comprehensive improvement effect on lipid metabolism (cluster-rank value for FBG and FINS: 3290.50 and for TGs and HDL-C: 2117.61).ConclusionNutritional supplementation is effective on CVD risk factors in overweight and obese patients. Probiotic supplementation might be the best intervention for blood glucose control; VD, probiotic + omega-3 have a better impact on improving lipid metabolism. Further studies are required to verify the current findings.https://www.frontiersin.org/articles/10.3389/fnut.2023.1140019/fullobesitynutritional supplementcardiovascular risk factorsbody compositionprobioticsBayesian network meta-analysis |
| spellingShingle | Zengli Yu Danyang Zhao Xinxin Liu Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis Frontiers in Nutrition obesity nutritional supplement cardiovascular risk factors body composition probiotics Bayesian network meta-analysis |
| title | Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis |
| title_full | Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis |
| title_fullStr | Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis |
| title_full_unstemmed | Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis |
| title_short | Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis |
| title_sort | nutritional supplements improve cardiovascular risk factors in overweight and obese patients a bayesian network meta analysis |
| topic | obesity nutritional supplement cardiovascular risk factors body composition probiotics Bayesian network meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1140019/full |
| work_keys_str_mv | AT zengliyu nutritionalsupplementsimprovecardiovascularriskfactorsinoverweightandobesepatientsabayesiannetworkmetaanalysis AT danyangzhao nutritionalsupplementsimprovecardiovascularriskfactorsinoverweightandobesepatientsabayesiannetworkmetaanalysis AT xinxinliu nutritionalsupplementsimprovecardiovascularriskfactorsinoverweightandobesepatientsabayesiannetworkmetaanalysis |