Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study
Abstract Objective We investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV), was associated with beta cell function, assessed from beta cell response during an oral glucose tolerance test (OGTT). Research design and met...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | https://doi.org/10.1186/s12933-023-01837-0 |
| _version_ | 1797832224796573696 |
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| author | Elisabetta Rinaldi Frank CT van der Heide Enzo Bonora Maddalena Trombetta Chiara Zusi Abraham A Kroon Miranda T Schram Carla JH van der Kallen Anke Wesselius Riccardo Bonadonna Andrea Mari Casper G Schalkwijk Marleen MJ van Greevenbroek Coen DA Stehouwer |
| author_facet | Elisabetta Rinaldi Frank CT van der Heide Enzo Bonora Maddalena Trombetta Chiara Zusi Abraham A Kroon Miranda T Schram Carla JH van der Kallen Anke Wesselius Riccardo Bonadonna Andrea Mari Casper G Schalkwijk Marleen MJ van Greevenbroek Coen DA Stehouwer |
| author_sort | Elisabetta Rinaldi |
| collection | DOAJ |
| description | Abstract Objective We investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV), was associated with beta cell function, assessed from beta cell response during an oral glucose tolerance test (OGTT). Research design and methods We used cross-sectional data from The Maastricht Study, a population-based cohort study (N = 2,007; age, mean ± SD:60 ± 8 years; 52% men; and 24% with type 2 diabetes). We used linear regression analyses with adjustment for potential confounders (demographic, cardiovascular, and lifestyle factors) to study the associations of time- and frequency-domain HRV (composite scores) with overall beta cell response (estimated from a composite score calculated from: C-peptidogenic index, overall insulin secretion, beta cell glucose sensitivity, beta cell potentiation factor, and beta cell rate sensitivity). In addition, we tested for interaction by sex and glucose metabolism status. Results After full adjustment, lower time- and frequency-domain HRV was significantly associated with lower overall beta cell response composite score (standardized beta, -0.055 [-0.098; -0.011] and − 0.051 [-0.095; -0.007], respectively). These associations were not modified by sex and there was no consistent pattern of interaction by glucose metabolism status. Conclusion The present etiological study found that worse autonomic function, estimated from lower HRV, was associated with worse beta cell function, estimated from a composite score in a population-based sample which covered the entire spectrum of glucose metabolism. Hence, autonomic dysfunction may contribute to beta cell dysfunction and, ultimately, to the alteration of glucose metabolism status from normal glucose metabolism to prediabetes and type 2 diabetes. |
| first_indexed | 2024-04-09T14:05:28Z |
| format | Article |
| id | doaj.art-664e12be7a9a4f32b2bbe32a087f9896 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-09T14:05:28Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-664e12be7a9a4f32b2bbe32a087f98962023-05-07T11:04:39ZengBMCCardiovascular Diabetology1475-28402023-05-0122111210.1186/s12933-023-01837-0Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht StudyElisabetta Rinaldi0Frank CT van der Heide1Enzo Bonora2Maddalena Trombetta3Chiara Zusi4Abraham A Kroon5Miranda T Schram6Carla JH van der Kallen7Anke Wesselius8Riccardo Bonadonna9Andrea Mari10Casper G Schalkwijk11Marleen MJ van Greevenbroek12Coen DA Stehouwer13Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University of VeronaCARIM School for Cardiovascular Diseases, Maastricht University (UM)Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University of VeronaDivision of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University of VeronaDivision of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University of VeronaCARIM School for Cardiovascular Diseases, Maastricht University (UM)CARIM School for Cardiovascular Diseases, Maastricht University (UM)CARIM School for Cardiovascular Diseases, Maastricht University (UM)Department of Epidemiology, UMDepartment of Medicine and Surgery, University of ParmaInstitute of Neuroscience, National Research CouncilCARIM School for Cardiovascular Diseases, Maastricht University (UM)CARIM School for Cardiovascular Diseases, Maastricht University (UM)CARIM School for Cardiovascular Diseases, Maastricht University (UM)Abstract Objective We investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV), was associated with beta cell function, assessed from beta cell response during an oral glucose tolerance test (OGTT). Research design and methods We used cross-sectional data from The Maastricht Study, a population-based cohort study (N = 2,007; age, mean ± SD:60 ± 8 years; 52% men; and 24% with type 2 diabetes). We used linear regression analyses with adjustment for potential confounders (demographic, cardiovascular, and lifestyle factors) to study the associations of time- and frequency-domain HRV (composite scores) with overall beta cell response (estimated from a composite score calculated from: C-peptidogenic index, overall insulin secretion, beta cell glucose sensitivity, beta cell potentiation factor, and beta cell rate sensitivity). In addition, we tested for interaction by sex and glucose metabolism status. Results After full adjustment, lower time- and frequency-domain HRV was significantly associated with lower overall beta cell response composite score (standardized beta, -0.055 [-0.098; -0.011] and − 0.051 [-0.095; -0.007], respectively). These associations were not modified by sex and there was no consistent pattern of interaction by glucose metabolism status. Conclusion The present etiological study found that worse autonomic function, estimated from lower HRV, was associated with worse beta cell function, estimated from a composite score in a population-based sample which covered the entire spectrum of glucose metabolism. Hence, autonomic dysfunction may contribute to beta cell dysfunction and, ultimately, to the alteration of glucose metabolism status from normal glucose metabolism to prediabetes and type 2 diabetes.https://doi.org/10.1186/s12933-023-01837-0 |
| spellingShingle | Elisabetta Rinaldi Frank CT van der Heide Enzo Bonora Maddalena Trombetta Chiara Zusi Abraham A Kroon Miranda T Schram Carla JH van der Kallen Anke Wesselius Riccardo Bonadonna Andrea Mari Casper G Schalkwijk Marleen MJ van Greevenbroek Coen DA Stehouwer Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study Cardiovascular Diabetology |
| title | Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study |
| title_full | Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study |
| title_fullStr | Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study |
| title_full_unstemmed | Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study |
| title_short | Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study |
| title_sort | lower heart rate variability an index of worse autonomic function is associated with worse beta cell response to a glycemic load in vivo the maastricht study |
| url | https://doi.org/10.1186/s12933-023-01837-0 |
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