Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer

BackgroundBladder cancer (BC) is the most common tumor of the urinary system. Non-muscle-invasive bladder cancer (NMIBC) has a high recurrence rate after surgery, and patients with muscle-invasive bladder cancer (MIBC) have poor quality of life after radical surgery. Understanding the molecular mech...

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Main Authors: WenBo Wu, GaoZhen Jia, Lei Chen, HaiTao Liu, ShuJie Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.731625/full
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author WenBo Wu
GaoZhen Jia
Lei Chen
HaiTao Liu
ShuJie Xia
author_facet WenBo Wu
GaoZhen Jia
Lei Chen
HaiTao Liu
ShuJie Xia
author_sort WenBo Wu
collection DOAJ
description BackgroundBladder cancer (BC) is the most common tumor of the urinary system. Non-muscle-invasive bladder cancer (NMIBC) has a high recurrence rate after surgery, and patients with muscle-invasive bladder cancer (MIBC) have poor quality of life after radical surgery. Understanding the molecular mechanism of bladder cancer is helpful for providing a more appropriate treatment approach. Annexins are calcium-binding proteins and play an important role in different tumor cells. However, the role of the annexin family in bladder cancer has not been studied in detail.MethodsONCOMINE, UALCAN, TIMER2.0, Kaplan-Meier Plotter, cBioPortal, and WebGestalt were utilized in this study.ResultsANXA2, ANXA3, ANXA4, ANXA8, and ANXA9 were significantly increased in bladder tumor tissues, while ANXA6, ANXA7, and ANXA11 were significantly decreased. ANXA1, ANXA2, ANXA3, ANXA5, ANXA6, ANXA7, and ANXA9 had prognostic value in bladder cancer. In addition, specific annexins were specifically expressed in different subtypes of MIBC and were related to the histological morphology of bladder tumors. ANXA1, ANXA2, ANXA3, ANXA5, ANXA6, ANXA7, and ANXA8 were highly expressed in basal-subtype MIBC, while ANXA4, ANXA9, ANXA10, and ANXA11 were mainly expressed in luminal-subtype MIBC. Finally, we analyzed the possible mechanisms of ANXAs in different subtypes of bladder cancer through GO and KEGG analyses and the correlation between ANXAs and immune infiltration in the tumor microenvironment.ConclusionTaken together, our results indicate that annexins might play important roles in BC and have the potential to be used as markers for subtype classification.
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spelling doaj.art-664fb19e10ce458780a8befc142485952022-12-21T19:58:09ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-08-011210.3389/fgene.2021.731625731625Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder CancerWenBo WuGaoZhen JiaLei ChenHaiTao LiuShuJie XiaBackgroundBladder cancer (BC) is the most common tumor of the urinary system. Non-muscle-invasive bladder cancer (NMIBC) has a high recurrence rate after surgery, and patients with muscle-invasive bladder cancer (MIBC) have poor quality of life after radical surgery. Understanding the molecular mechanism of bladder cancer is helpful for providing a more appropriate treatment approach. Annexins are calcium-binding proteins and play an important role in different tumor cells. However, the role of the annexin family in bladder cancer has not been studied in detail.MethodsONCOMINE, UALCAN, TIMER2.0, Kaplan-Meier Plotter, cBioPortal, and WebGestalt were utilized in this study.ResultsANXA2, ANXA3, ANXA4, ANXA8, and ANXA9 were significantly increased in bladder tumor tissues, while ANXA6, ANXA7, and ANXA11 were significantly decreased. ANXA1, ANXA2, ANXA3, ANXA5, ANXA6, ANXA7, and ANXA9 had prognostic value in bladder cancer. In addition, specific annexins were specifically expressed in different subtypes of MIBC and were related to the histological morphology of bladder tumors. ANXA1, ANXA2, ANXA3, ANXA5, ANXA6, ANXA7, and ANXA8 were highly expressed in basal-subtype MIBC, while ANXA4, ANXA9, ANXA10, and ANXA11 were mainly expressed in luminal-subtype MIBC. Finally, we analyzed the possible mechanisms of ANXAs in different subtypes of bladder cancer through GO and KEGG analyses and the correlation between ANXAs and immune infiltration in the tumor microenvironment.ConclusionTaken together, our results indicate that annexins might play important roles in BC and have the potential to be used as markers for subtype classification.https://www.frontiersin.org/articles/10.3389/fgene.2021.731625/fullannexinNMIBCMIBCprognosispublic databases
spellingShingle WenBo Wu
GaoZhen Jia
Lei Chen
HaiTao Liu
ShuJie Xia
Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
Frontiers in Genetics
annexin
NMIBC
MIBC
prognosis
public databases
title Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
title_full Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
title_fullStr Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
title_full_unstemmed Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
title_short Analysis of the Expression and Prognostic Value of Annexin Family Proteins in Bladder Cancer
title_sort analysis of the expression and prognostic value of annexin family proteins in bladder cancer
topic annexin
NMIBC
MIBC
prognosis
public databases
url https://www.frontiersin.org/articles/10.3389/fgene.2021.731625/full
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