Developing a 3-D computational model of neurons in the central amygdala to understand pharmacological targets for pain

Developing a 3-D computational model of neurons in the central amygdala to understand pharmacological targets for pain

Neuropathic and nociplastic pain are major causes of pain and involve brain areas such as the central nucleus of the amygdala (CeA). Within the CeA, neurons expressing protein kinase c-delta (PKCδ) or somatostatin (SST) have opposing roles in pain-like modulation. In this manuscript, we describe our...

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Bibliographic Details
Main Authors: Rachael Miller Neilan, Carley Reith, Iniya Anandan, Kayla Kraeuter, Heather N. Allen, Benedict J. Kolber
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pain Research
Subjects:
neuropathic pain
central nucleus of the amygdala (CeA)
agent-based model (ABM)
computational model
somatostatin
protein kinase c delta (PKCδ)
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2023.1183553/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2023.1183553/full

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