SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA
In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed. The soluble forms of membrane antigens, which can makes up oligomers, consists of subunits, belong to one antigen, or which can make up solu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2022-12-01
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| Series: | Сеченовский вестник |
| Subjects: | |
| Online Access: | https://www.sechenovmedj.com/jour/article/view/551 |
| _version_ | 1797873647765946368 |
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| author | A. V. Karaulov M. Yu. Lebedev V. V. Novikov |
| author_facet | A. V. Karaulov M. Yu. Lebedev V. V. Novikov |
| author_sort | A. V. Karaulov |
| collection | DOAJ |
| description | In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed. The soluble forms of membrane antigens, which can makes up oligomers, consists of subunits, belong to one antigen, or which can make up soluble complexes (associations), composed of pair receptor–ligand. The changes in concentration of soluble analogs of membrane antigens in patients with mechanical injury, craniocerebral trauma and burning injury are the perspective prognostic markers of possibility of development complication. The state of soluble differentiation molecules pool is one from factors which define the outcomes of underlying disease. Peculiarity of immune system cells transcriptome, associated with mRNA of soluble and membrane differentiation antigens have prognostic character in trauma patients. |
| first_indexed | 2024-04-10T01:19:36Z |
| format | Article |
| id | doaj.art-665026e1266248a18360eab6194fc93d |
| institution | Directory Open Access Journal |
| issn | 2218-7332 2658-3348 |
| language | Russian |
| last_indexed | 2024-04-10T01:19:36Z |
| publishDate | 2022-12-01 |
| publisher | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) |
| record_format | Article |
| series | Сеченовский вестник |
| spelling | doaj.art-665026e1266248a18360eab6194fc93d2023-03-13T09:51:34ZrusFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Сеченовский вестник2218-73322658-33482022-12-01016368245SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMAA. V. Karaulov0M. Yu. Lebedev1V. V. Novikov2Первый московский государственный медицинский университет им. И.М. СеченоваФГУ «Нижегородский научно-исследовательский институт травматологии и ортопедии федерального агентства по высокотехнологичной медицинский помощи» (ФГУ «ННИИТО Росмедтехнологий»)ГОУ ВПО «Нижегородский государственный университет им. Н.И.Лобачевского» Федерального агенства образования РФ (ННГУ им. Н.И.Лобачевского)In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed. The soluble forms of membrane antigens, which can makes up oligomers, consists of subunits, belong to one antigen, or which can make up soluble complexes (associations), composed of pair receptor–ligand. The changes in concentration of soluble analogs of membrane antigens in patients with mechanical injury, craniocerebral trauma and burning injury are the perspective prognostic markers of possibility of development complication. The state of soluble differentiation molecules pool is one from factors which define the outcomes of underlying disease. Peculiarity of immune system cells transcriptome, associated with mRNA of soluble and membrane differentiation antigens have prognostic character in trauma patients.https://www.sechenovmedj.com/jour/article/view/551mechanical injurycraniocerebral traumaburning injurysoluble differentiation antigensmolecules of histocompatibilityimmune response regulation |
| spellingShingle | A. V. Karaulov M. Yu. Lebedev V. V. Novikov SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA Сеченовский вестник mechanical injury craniocerebral trauma burning injury soluble differentiation antigens molecules of histocompatibility immune response regulation |
| title | SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA |
| title_full | SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA |
| title_fullStr | SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA |
| title_full_unstemmed | SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA |
| title_short | SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA |
| title_sort | soluble differentiating antigens and histocompatibility molecules in patients with different kind of trauma |
| topic | mechanical injury craniocerebral trauma burning injury soluble differentiation antigens molecules of histocompatibility immune response regulation |
| url | https://www.sechenovmedj.com/jour/article/view/551 |
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