Advances in the application of proteomics in lung cancer
Although the incidence and mortality of lung cancer have decreased significantly in the past decade, it is still one of the leading causes of death, which greatly impairs people’s life and health. Proteomics is an emerging technology that involves the application of techniques for identifying and qu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.993781/full |
| _version_ | 1811203909986811904 |
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| author | Bai Ling Zhengyu Zhang Ze Xiang Yiqi Cai Xinyue Zhang Jian Wu |
| author_facet | Bai Ling Zhengyu Zhang Ze Xiang Yiqi Cai Xinyue Zhang Jian Wu |
| author_sort | Bai Ling |
| collection | DOAJ |
| description | Although the incidence and mortality of lung cancer have decreased significantly in the past decade, it is still one of the leading causes of death, which greatly impairs people’s life and health. Proteomics is an emerging technology that involves the application of techniques for identifying and quantifying the overall proteins in cells, tissues and organisms, and can be combined with genomics, transcriptomics to form a multi-omics research model. By comparing the content of proteins between normal and tumor tissues, proteomics can be applied to different clinical aspects like diagnosis, treatment, and prognosis, especially the exploration of disease biomarkers and therapeutic targets. The applications of proteomics have promoted the research on lung cancer. To figure out potential applications of proteomics associated with lung cancer, we summarized the role of proteomics in studies about tumorigenesis, diagnosis, prognosis, treatment and resistance of lung cancer in this review, which will provide guidance for more rational application of proteomics and potential therapeutic strategies of lung cancer. |
| first_indexed | 2024-04-12T03:02:51Z |
| format | Article |
| id | doaj.art-6652a43a7d014a689470a88e8f2b7358 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T03:02:51Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6652a43a7d014a689470a88e8f2b73582022-12-22T03:50:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.993781993781Advances in the application of proteomics in lung cancerBai Ling0Zhengyu Zhang1Ze Xiang2Yiqi Cai3Xinyue Zhang4Jian Wu5Department of Pharmacy, The Yancheng Clinical College of Xuzhou Medical University, The First people’s Hospital of Yancheng, Yancheng, ChinaNanjing Medical University School of Medicine, Nanjing, ChinaZhejiang University School of Medicine, Hangzhou, ChinaZhejiang University School of Medicine, Hangzhou, ChinaStomatology Hospital, School of stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaAlthough the incidence and mortality of lung cancer have decreased significantly in the past decade, it is still one of the leading causes of death, which greatly impairs people’s life and health. Proteomics is an emerging technology that involves the application of techniques for identifying and quantifying the overall proteins in cells, tissues and organisms, and can be combined with genomics, transcriptomics to form a multi-omics research model. By comparing the content of proteins between normal and tumor tissues, proteomics can be applied to different clinical aspects like diagnosis, treatment, and prognosis, especially the exploration of disease biomarkers and therapeutic targets. The applications of proteomics have promoted the research on lung cancer. To figure out potential applications of proteomics associated with lung cancer, we summarized the role of proteomics in studies about tumorigenesis, diagnosis, prognosis, treatment and resistance of lung cancer in this review, which will provide guidance for more rational application of proteomics and potential therapeutic strategies of lung cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.993781/fulllung cancerproteomicstumorigenesisdiagnosistreatment |
| spellingShingle | Bai Ling Zhengyu Zhang Ze Xiang Yiqi Cai Xinyue Zhang Jian Wu Advances in the application of proteomics in lung cancer Frontiers in Oncology lung cancer proteomics tumorigenesis diagnosis treatment |
| title | Advances in the application of proteomics in lung cancer |
| title_full | Advances in the application of proteomics in lung cancer |
| title_fullStr | Advances in the application of proteomics in lung cancer |
| title_full_unstemmed | Advances in the application of proteomics in lung cancer |
| title_short | Advances in the application of proteomics in lung cancer |
| title_sort | advances in the application of proteomics in lung cancer |
| topic | lung cancer proteomics tumorigenesis diagnosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.993781/full |
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