Elevations in Liver Transaminases in COVID-19: (How) Are They Related?
Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and i...
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.705247/full |
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| author | Henrique Pott-Junior Natália Queiroz Prado Bittencourt Silvana F. G. Chacha Rafael Luís Luporini Rafael Luís Luporini Marcia Regina Cominetti Fernanda de Freitas Anibal Fernanda de Freitas Anibal |
| author_facet | Henrique Pott-Junior Natália Queiroz Prado Bittencourt Silvana F. G. Chacha Rafael Luís Luporini Rafael Luís Luporini Marcia Regina Cominetti Fernanda de Freitas Anibal Fernanda de Freitas Anibal |
| author_sort | Henrique Pott-Junior |
| collection | DOAJ |
| description | Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response. |
| first_indexed | 2024-12-17T19:46:10Z |
| format | Article |
| id | doaj.art-6652d011aa334344aaa3cca4a6b4898c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-17T19:46:10Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-6652d011aa334344aaa3cca4a6b4898c2022-12-21T21:34:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.705247705247Elevations in Liver Transaminases in COVID-19: (How) Are They Related?Henrique Pott-Junior0Natália Queiroz Prado Bittencourt1Silvana F. G. Chacha2Rafael Luís Luporini3Rafael Luís Luporini4Marcia Regina Cominetti5Fernanda de Freitas Anibal6Fernanda de Freitas Anibal7Department of Medicine, Federal University of São Carlos, São Carlos, BrazilDepartment of Medicine, Federal University of São Carlos, São Carlos, BrazilDepartment of Medicine, Federal University of São Carlos, São Carlos, BrazilDepartment of Medicine, Federal University of São Carlos, São Carlos, BrazilBiotechnology Graduate Program, Federal University of São Carlos, São Carlos, BrazilDepartment of Gerontology, Federal University of São Carlos, São Carlos, BrazilBiotechnology Graduate Program, Federal University of São Carlos, São Carlos, BrazilDepartment of Biological Sciences Parasitology, Federal University of São Carlos, São Carlos, BrazilLiver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease. This cross-sectional study explored the relationship between the elevations in liver transaminases and inflammatory parameters in 209 adults with COVID-19. Demographic and clinical data, serum levels of inflammatory cytokines and liver aminotransferases were analyzed. Three groups were formed according to the liver transaminase abnormalities: (I) Normal transaminases, (II) Borderline transaminases elevation, and (III) Mild to severe transaminases elevation. Altered liver transaminases were directly related to disease severity, showing association with the NEWS2 score at admission and greater need for ICU or death. Moreover, higher levels of IL-2 and CRP were associated with borderline transaminases elevations, whereas higher levels of IL-10 and Neutrophil to Lymphocyte ratio were associated with mild to severe transaminases elevation. These results reinforce the importance of liver transaminases in patients with COVID-19 as a complementary marker for disease severity and also point to them as a parameter reflecting the continuous dynamics between viral infection and the immune response.https://www.frontiersin.org/articles/10.3389/fmed.2021.705247/fullinflammationinterleukin-2interleukin-10lymphocytesSARS-CoV-2hepatitis |
| spellingShingle | Henrique Pott-Junior Natália Queiroz Prado Bittencourt Silvana F. G. Chacha Rafael Luís Luporini Rafael Luís Luporini Marcia Regina Cominetti Fernanda de Freitas Anibal Fernanda de Freitas Anibal Elevations in Liver Transaminases in COVID-19: (How) Are They Related? Frontiers in Medicine inflammation interleukin-2 interleukin-10 lymphocytes SARS-CoV-2 hepatitis |
| title | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
| title_full | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
| title_fullStr | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
| title_full_unstemmed | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
| title_short | Elevations in Liver Transaminases in COVID-19: (How) Are They Related? |
| title_sort | elevations in liver transaminases in covid 19 how are they related |
| topic | inflammation interleukin-2 interleukin-10 lymphocytes SARS-CoV-2 hepatitis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.705247/full |
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