Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis
Background: Inflammation caused by chronic diseases and the constant use of systemic corticosteroids could be linked to the increased incidence of venous thromboembolic disease. Clinical case: A 47 year-old man with severe asthma of difficult control and allergic bronchopulmonary aspergillosis who...
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2019-04-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/352 |
| _version_ | 1797719787333222400 |
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| author | Liliana Guevara-Saldaña Libia Susana Díez-Zuluaga Catalina María Gómez-Henao Ricardo Cardona |
| author_facet | Liliana Guevara-Saldaña Libia Susana Díez-Zuluaga Catalina María Gómez-Henao Ricardo Cardona |
| author_sort | Liliana Guevara-Saldaña |
| collection | DOAJ |
| description | Background: Inflammation caused by chronic diseases and the constant use of systemic corticosteroids could be linked to the increased incidence of venous thromboembolic disease.
Clinical case: A 47 year-old man with severe asthma of difficult control and allergic bronchopulmonary aspergillosis who, although the treatment was optimal, continued to have recurrent exacerbations and the need for systemic corticosteroids. He had edema in his left leg. Through venous Doppler ultrasound, deep vein thrombosis was confirmed; because of the images of the pulmonary V/Q gammagram, the presence of chronic pulmonary thromboembolism was suspected. 5 mg of apixaban were prescribed every 12 hours; in less than two months, symptom control was achieved without hospitalization, systemic corticosteroids or short-acting B2 agonists. Gradual withdrawal of omalizumab was started with good tolerance.
Conclusions: The important decrease of bronchial symptoms with the blood thinner confirmed the suspicion that the exacerbations were caused by chronic pulmonary thromboembolism. |
| first_indexed | 2024-03-12T09:09:53Z |
| format | Article |
| id | doaj.art-665728bb8c504e33848086514a3d4668 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T09:09:53Z |
| publishDate | 2019-04-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-665728bb8c504e33848086514a3d46682023-09-02T15:02:21ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902019-04-0166112813110.29262/ram.v66i1.352396Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosisLiliana Guevara-Saldaña0Libia Susana Díez-Zuluaga1Catalina María Gómez-Henao2Ricardo Cardona3Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, AntioquiaUniversidad de Antioquia, Grupo de Alergología Clínica y Experimental, AntioquiaUniversidad de Antioquia, Grupo de Alergología Clínica y Experimental, AntioquiaUniversidad de Antioquia, Grupo de Alergología Clínica y Experimental, AntioquiaBackground: Inflammation caused by chronic diseases and the constant use of systemic corticosteroids could be linked to the increased incidence of venous thromboembolic disease. Clinical case: A 47 year-old man with severe asthma of difficult control and allergic bronchopulmonary aspergillosis who, although the treatment was optimal, continued to have recurrent exacerbations and the need for systemic corticosteroids. He had edema in his left leg. Through venous Doppler ultrasound, deep vein thrombosis was confirmed; because of the images of the pulmonary V/Q gammagram, the presence of chronic pulmonary thromboembolism was suspected. 5 mg of apixaban were prescribed every 12 hours; in less than two months, symptom control was achieved without hospitalization, systemic corticosteroids or short-acting B2 agonists. Gradual withdrawal of omalizumab was started with good tolerance. Conclusions: The important decrease of bronchial symptoms with the blood thinner confirmed the suspicion that the exacerbations were caused by chronic pulmonary thromboembolism.http://revistaalergia.mx/ojs/index.php/ram/article/view/352tromboembolismo pulmonarasmaaspergilosis broncopulmonaresteroides |
| spellingShingle | Liliana Guevara-Saldaña Libia Susana Díez-Zuluaga Catalina María Gómez-Henao Ricardo Cardona Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis Revista Alergia México tromboembolismo pulmonar asma aspergilosis broncopulmonar esteroides |
| title | Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| title_full | Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| title_fullStr | Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| title_full_unstemmed | Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| title_short | Asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| title_sort | asthma of difficult control linked to pulmonary thromboembolism and bronchopulmonary aspergillosis |
| topic | tromboembolismo pulmonar asma aspergilosis broncopulmonar esteroides |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/352 |
| work_keys_str_mv | AT lilianaguevarasaldana asthmaofdifficultcontrollinkedtopulmonarythromboembolismandbronchopulmonaryaspergillosis AT libiasusanadiezzuluaga asthmaofdifficultcontrollinkedtopulmonarythromboembolismandbronchopulmonaryaspergillosis AT catalinamariagomezhenao asthmaofdifficultcontrollinkedtopulmonarythromboembolismandbronchopulmonaryaspergillosis AT ricardocardona asthmaofdifficultcontrollinkedtopulmonarythromboembolismandbronchopulmonaryaspergillosis |