Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy
Introduction: Pericardial effusion is an indicator of poor prognosis in patients with cancer. We investigated the effect of pericardial effusion development on right ventricular function in oncology patients receiving chemotherapy for malignancy. Methods: A total of 90 patients who were followed up...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-11-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/effect-of-pericardial-effusion-on-right-ventricula/63652
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| _version_ | 1827629764006903808 |
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| author | Sefa Tatar Yunus Emre Yavuz İrem Oktay Nergiz Aydın Yakup Alsancak Abdullah İçli |
| author_facet | Sefa Tatar Yunus Emre Yavuz İrem Oktay Nergiz Aydın Yakup Alsancak Abdullah İçli |
| author_sort | Sefa Tatar |
| collection | DOAJ |
| description | Introduction: Pericardial effusion is an indicator of poor prognosis in patients with cancer. We investigated the effect of pericardial effusion development on right ventricular function in oncology patients receiving chemotherapy for malignancy. Methods: A total of 90 patients who were followed up in the oncology clinic and who applied to our outpatient clinic for routine cardiac examination were included in the study. Echocardiography was performed on the patients, and they were divided into two groups: patients with and without pericardial effusion. Demographic characteristics and, clinical and laboratory findings of the patients were recorded. The right ventricular functions of the patients were then evaluated. Results: Pericardial effusion was in 30 (33.3%) of 90 patients included in the study. The mean age of patients without pericardial effusion was 57.33±15.59, and the mean age of patients with effusion was 60.27±13.51, and it was similar between the groups (p=0.36). No statistically significant difference was detected between the groups in right ventricular (RV) fractionated area change, RV-early peak, tricuspid annular plane systolic excursion, pulmonary artery pressure, E/E', and heart failure with preserved ejection fraction values, which are parameters that indicate right ventricular functions and diastolic dysfunction. However, RV systolic velocity and RV-AM, which are indicators of diastolic dysfunction, were found at higher rates in the patient group with pericardial effusion (p-value 0.041 and 0.001, respectively). In addition, Mitral E velocity was found to be lower in the patient group with pericardial effusion (p=0.032). Conclusion: In malignancy patients who develop pericardial effusion, we recommend that diastolic parameters be checked and close clinical follow-up of the patients be performed before overt heart failure clinic develops. It should be kept in mind that the development of pericardial effusion in oncology patients receiving chemotherapy does not mean right ventricular failure. |
| first_indexed | 2024-03-09T13:57:01Z |
| format | Article |
| id | doaj.art-6657d1c35ffa4e429e64033f7422396b |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-03-09T13:57:01Z |
| publishDate | 2023-11-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-6657d1c35ffa4e429e64033f7422396b2023-11-30T12:44:52ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2023-11-0124439940310.4274/imj.galenos.2023.0218513049054Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving ChemotherapySefa Tatar0Yunus Emre Yavuz1İrem Oktay2Nergiz Aydın3Yakup Alsancak4Abdullah İçli5 Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiology, Konya, Turkey Siirt Training and Research Hospital, Clinic of Cardiology, Siirt, Turkey Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiology, Konya, Turkey Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiology, Konya, Turkey Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiology, Konya, Turkey Necmettin Erbakan University, Meram Faculty of Medicine, Department of Cardiology, Konya, Turkey Introduction: Pericardial effusion is an indicator of poor prognosis in patients with cancer. We investigated the effect of pericardial effusion development on right ventricular function in oncology patients receiving chemotherapy for malignancy. Methods: A total of 90 patients who were followed up in the oncology clinic and who applied to our outpatient clinic for routine cardiac examination were included in the study. Echocardiography was performed on the patients, and they were divided into two groups: patients with and without pericardial effusion. Demographic characteristics and, clinical and laboratory findings of the patients were recorded. The right ventricular functions of the patients were then evaluated. Results: Pericardial effusion was in 30 (33.3%) of 90 patients included in the study. The mean age of patients without pericardial effusion was 57.33±15.59, and the mean age of patients with effusion was 60.27±13.51, and it was similar between the groups (p=0.36). No statistically significant difference was detected between the groups in right ventricular (RV) fractionated area change, RV-early peak, tricuspid annular plane systolic excursion, pulmonary artery pressure, E/E', and heart failure with preserved ejection fraction values, which are parameters that indicate right ventricular functions and diastolic dysfunction. However, RV systolic velocity and RV-AM, which are indicators of diastolic dysfunction, were found at higher rates in the patient group with pericardial effusion (p-value 0.041 and 0.001, respectively). In addition, Mitral E velocity was found to be lower in the patient group with pericardial effusion (p=0.032). Conclusion: In malignancy patients who develop pericardial effusion, we recommend that diastolic parameters be checked and close clinical follow-up of the patients be performed before overt heart failure clinic develops. It should be kept in mind that the development of pericardial effusion in oncology patients receiving chemotherapy does not mean right ventricular failure. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/effect-of-pericardial-effusion-on-right-ventricula/63652 chemotherapypericardial effusiondiastolic heart failureright ventricular failure |
| spellingShingle | Sefa Tatar Yunus Emre Yavuz İrem Oktay Nergiz Aydın Yakup Alsancak Abdullah İçli Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy İstanbul Medical Journal chemotherapy pericardial effusion diastolic heart failure right ventricular failure |
| title | Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy |
| title_full | Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy |
| title_fullStr | Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy |
| title_full_unstemmed | Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy |
| title_short | Effect of Pericardial Effusion on Right Ventricular Functions in Oncology Patients Receiving Chemotherapy |
| title_sort | effect of pericardial effusion on right ventricular functions in oncology patients receiving chemotherapy |
| topic | chemotherapy pericardial effusion diastolic heart failure right ventricular failure |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/effect-of-pericardial-effusion-on-right-ventricula/63652
|
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