The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
IntroductionA worldwide increase in the incidence of thyroid cancer during the last decades is largely due to papillary thyroid microcarcinomas (MPTCs), which are mostly low-risk tumors. In view of recent clinical recommendations to reduce the extent of surgery for low-risk thyroid cancer, and persi...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1078258/full |
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| author | Tetiana Bogdanova Tetiana Bogdanova Serhii Chernyshov Liudmyla Zurnadzhy Liudmyla Zurnadzhy Tatiana I. Rogounovitch Norisato Mitsutake Norisato Mitsutake Mykola Tronko Masahiro Ito Michael Bolgov Sergii Masiuk Shunichi Yamashita Shunichi Yamashita Vladimir A. Saenko |
| author_facet | Tetiana Bogdanova Tetiana Bogdanova Serhii Chernyshov Liudmyla Zurnadzhy Liudmyla Zurnadzhy Tatiana I. Rogounovitch Norisato Mitsutake Norisato Mitsutake Mykola Tronko Masahiro Ito Michael Bolgov Sergii Masiuk Shunichi Yamashita Shunichi Yamashita Vladimir A. Saenko |
| author_sort | Tetiana Bogdanova |
| collection | DOAJ |
| description | IntroductionA worldwide increase in the incidence of thyroid cancer during the last decades is largely due to papillary thyroid microcarcinomas (MPTCs), which are mostly low-risk tumors. In view of recent clinical recommendations to reduce the extent of surgery for low-risk thyroid cancer, and persisting uncertainty about the impact of radiation history, we set out to address whether clinicopathological characteristics and prognosis of post-Chornobyl MPTCs were changing with regard to: i) the latency period, ii) probability of causation (POC) of a tumor due to radiation, and iii) tumor size.MethodsPatients (n = 465) aged up to 50 years at diagnosis who lived in April, 1986 in six northern, most radiocontaminated regions of Ukraine were studied.ResultsLatency period was statistically significantly associated with the reduction of POC level, tumor size and the frequency of fully encapsulated MPTCs. In contrast, the frequency of oncocytic changes and the BRAFV600E mutation increased. Invasive properties and clinical follow-up results did not depend on latency except for a lower frequency of complete remission after postsurgical radioiodine therapy. The POC level was associated with more frequent extrathyroidal extension, and lymphatic/vascular invasion, less frequent oncocytic changes and BRAFV600E, and did not associate with any clinical indicator. Tumor size was negatively associated with the latency period and BRAFV600E, and had a statistically significant effect on invasive properties of MPTCs: both the integrative invasiveness score and its components such as lymphatic/vascular invasion, extrathyroidal extension and lymph node metastases increased. The frequency of total thyroidectomy, neck lymph node dissection and radioiodine therapy also increased with the larger tumor size. The duration of the latency period, POC level or tumor size did not associate with the chance of disease recurrence.DiscussionIn summary, we did not observe overall worsening of the clinicopathological features or treatment results of radiogenic MPTCs that could be associated with the latency period or POC level, suggesting that radiation history did not strongly affect those in the analyzed MPTC patients. However, the increase in the invasive properties with tumor size indicates the need for individual risk stratification for each MPTC patient, regardless of radiation history, for treatment decision-making. |
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| language | English |
| last_indexed | 2024-04-12T01:44:02Z |
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| spelling | doaj.art-6657d2b66cce44db915d89a0c9bd60502022-12-22T03:53:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10782581078258The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposureTetiana Bogdanova0Tetiana Bogdanova1Serhii Chernyshov2Liudmyla Zurnadzhy3Liudmyla Zurnadzhy4Tatiana I. Rogounovitch5Norisato Mitsutake6Norisato Mitsutake7Mykola Tronko8Masahiro Ito9Michael Bolgov10Sergii Masiuk11Shunichi Yamashita12Shunichi Yamashita13Vladimir A. Saenko14Laboratory of Morphology of Endocrine System, State Institution “VP Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineDepartment of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanDepartment of Surgery of Endocrine Glands, State Institution “VP Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineLaboratory of Morphology of Endocrine System, State Institution “VP Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineDepartment of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanDepartment of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanDepartment of Fundamental and Applied Problems of Endocrinology, State Institution “VP Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineDepartment of Diagnostic Pathology, National Hospital Organization Nagasaki Medical Center, Omura, JapanDepartment of Surgery of Endocrine Glands, State Institution “VP Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkraineRadiation Protection Laboratory, State Institution “National Research Center of Radiation Medicine of the National Academy of Medical Science of Ukraine”, Kyiv, UkraineFukushima Medical University, Fukushima, JapanNational Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba, JapanDepartment of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanIntroductionA worldwide increase in the incidence of thyroid cancer during the last decades is largely due to papillary thyroid microcarcinomas (MPTCs), which are mostly low-risk tumors. In view of recent clinical recommendations to reduce the extent of surgery for low-risk thyroid cancer, and persisting uncertainty about the impact of radiation history, we set out to address whether clinicopathological characteristics and prognosis of post-Chornobyl MPTCs were changing with regard to: i) the latency period, ii) probability of causation (POC) of a tumor due to radiation, and iii) tumor size.MethodsPatients (n = 465) aged up to 50 years at diagnosis who lived in April, 1986 in six northern, most radiocontaminated regions of Ukraine were studied.ResultsLatency period was statistically significantly associated with the reduction of POC level, tumor size and the frequency of fully encapsulated MPTCs. In contrast, the frequency of oncocytic changes and the BRAFV600E mutation increased. Invasive properties and clinical follow-up results did not depend on latency except for a lower frequency of complete remission after postsurgical radioiodine therapy. The POC level was associated with more frequent extrathyroidal extension, and lymphatic/vascular invasion, less frequent oncocytic changes and BRAFV600E, and did not associate with any clinical indicator. Tumor size was negatively associated with the latency period and BRAFV600E, and had a statistically significant effect on invasive properties of MPTCs: both the integrative invasiveness score and its components such as lymphatic/vascular invasion, extrathyroidal extension and lymph node metastases increased. The frequency of total thyroidectomy, neck lymph node dissection and radioiodine therapy also increased with the larger tumor size. The duration of the latency period, POC level or tumor size did not associate with the chance of disease recurrence.DiscussionIn summary, we did not observe overall worsening of the clinicopathological features or treatment results of radiogenic MPTCs that could be associated with the latency period or POC level, suggesting that radiation history did not strongly affect those in the analyzed MPTC patients. However, the increase in the invasive properties with tumor size indicates the need for individual risk stratification for each MPTC patient, regardless of radiation history, for treatment decision-making.https://www.frontiersin.org/articles/10.3389/fendo.2022.1078258/fullradiogenic papillary thyroid microcarcinomaChornobyllatency periodprobability of causationinvasivenessclinical characteristics |
| spellingShingle | Tetiana Bogdanova Tetiana Bogdanova Serhii Chernyshov Liudmyla Zurnadzhy Liudmyla Zurnadzhy Tatiana I. Rogounovitch Norisato Mitsutake Norisato Mitsutake Mykola Tronko Masahiro Ito Michael Bolgov Sergii Masiuk Shunichi Yamashita Shunichi Yamashita Vladimir A. Saenko The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure Frontiers in Endocrinology radiogenic papillary thyroid microcarcinoma Chornobyl latency period probability of causation invasiveness clinical characteristics |
| title | The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| title_full | The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| title_fullStr | The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| title_full_unstemmed | The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| title_short | The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| title_sort | relationship of the clinicopathological characteristics and treatment results of post chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure |
| topic | radiogenic papillary thyroid microcarcinoma Chornobyl latency period probability of causation invasiveness clinical characteristics |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1078258/full |
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