Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB)
Introduction: Vitamin D is now known to be essential to Mycobacterium tuberculosis containment and killing through activation of 25-hydroxyvitamin-D receptors (VDRs) present on all immune cells or obtained from dietary food stuffs as either vitamin D3 or vegetable vitamin D2 (also known as ergoca...
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JCDR Research and Publications Private Limited
2017-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10636/30084_CE(RA1)_F(T)PF1-(SY_MJ_PY)_PFA(VJ_SS).pdf |
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| author | Swati Gautam Amita Jain Salman Akhtar Apala Priyadarshini Shyam Pyari Jaiswar |
| author_facet | Swati Gautam Amita Jain Salman Akhtar Apala Priyadarshini Shyam Pyari Jaiswar |
| author_sort | Swati Gautam |
| collection | DOAJ |
| description | Introduction: Vitamin D is now known to be essential to Mycobacterium tuberculosis containment and killing through activation
of 25-hydroxyvitamin-D receptors (VDRs) present on all immune
cells or obtained from dietary food stuffs as either vitamin D3 or
vegetable vitamin D2 (also known as ergocalciferol).
Aim: To evaluate the association of serum vitamin D level
between the Female Genital Tuberculosis (FGTB) cases and
healthy controls.
Materials and Methods: Total 120 cases and 120 controls
enrolled for the study following inclusion and exclusion criteria.
Detailed clinical history was taken from each subjects. Total of
3 ml of the blood was collected in EDTA vial from each subject
(case and control). Quantification of serum vitamin D level was
measured by active human vitamin D ELISA kit using an ELISA
reader. Statistical analysis was done using Statistical Package
for Social Science (SPSS) version 21.0. A p-value <0.05 was
considered as significant.
Results: A total of 120 confirmed FGTB cases and 120 healthy
control enrolled for study. Out of 120 women 97.5%, 10.0%,
3.3%, 3.3% were detected positive for M. tuberculosis respectively. Comparing the mean demographic value of age and BMI
were (29.03±3.127, 28.03±3.00) and (22.92±3.33, 24.15±3.97)
respectively with the p=0.012* and p=0.010* found to be significant among cases and controls. The mean serum vitamin D
level was 14.96±8.81 in cases and 23.00±8.83 in controls with
p-value<0.001. There was a significant positive association found
in low serum vitamin D level among FGTB cases than controls.
Conclusion: Vitamin D is important for normal immune cell
function, as well as regression of FGTB disease. FGTB may be
controlled by regulating the serum vitamin D level concentration.
This study suggests that, vitamin D deficiency and BMI is
strongly associated with the progression of active FGTB disease
which alters the expression of antimicrobial peptide and lead to
the persistence of TB infection. Therefore, serum vitamin D level
may play an important role in treatment of FGTB. |
| first_indexed | 2024-12-18T23:01:38Z |
| format | Article |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-18T23:01:38Z |
| publishDate | 2017-09-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-665a18f487214a69b25729264ed13c5e2022-12-21T20:48:33ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-09-01119DC18DC2010.7860/JCDR/2017/30084.10636Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB)Swati Gautam0Amita Jain1Salman Akhtar2Apala Priyadarshini3Shyam Pyari Jaiswar4PhD Scholar, Department of Biosciences, Integral University, and Department of Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, India. Professor, Department of Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, India. Assistant Professor, Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.Senior Resident, Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, Uttar Pradesh, India.Professor, Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, Uttar Pradesh, India.Introduction: Vitamin D is now known to be essential to Mycobacterium tuberculosis containment and killing through activation of 25-hydroxyvitamin-D receptors (VDRs) present on all immune cells or obtained from dietary food stuffs as either vitamin D3 or vegetable vitamin D2 (also known as ergocalciferol). Aim: To evaluate the association of serum vitamin D level between the Female Genital Tuberculosis (FGTB) cases and healthy controls. Materials and Methods: Total 120 cases and 120 controls enrolled for the study following inclusion and exclusion criteria. Detailed clinical history was taken from each subjects. Total of 3 ml of the blood was collected in EDTA vial from each subject (case and control). Quantification of serum vitamin D level was measured by active human vitamin D ELISA kit using an ELISA reader. Statistical analysis was done using Statistical Package for Social Science (SPSS) version 21.0. A p-value <0.05 was considered as significant. Results: A total of 120 confirmed FGTB cases and 120 healthy control enrolled for study. Out of 120 women 97.5%, 10.0%, 3.3%, 3.3% were detected positive for M. tuberculosis respectively. Comparing the mean demographic value of age and BMI were (29.03±3.127, 28.03±3.00) and (22.92±3.33, 24.15±3.97) respectively with the p=0.012* and p=0.010* found to be significant among cases and controls. The mean serum vitamin D level was 14.96±8.81 in cases and 23.00±8.83 in controls with p-value<0.001. There was a significant positive association found in low serum vitamin D level among FGTB cases than controls. Conclusion: Vitamin D is important for normal immune cell function, as well as regression of FGTB disease. FGTB may be controlled by regulating the serum vitamin D level concentration. This study suggests that, vitamin D deficiency and BMI is strongly associated with the progression of active FGTB disease which alters the expression of antimicrobial peptide and lead to the persistence of TB infection. Therefore, serum vitamin D level may play an important role in treatment of FGTB.https://jcdr.net/articles/PDF/10636/30084_CE(RA1)_F(T)PF1-(SY_MJ_PY)_PFA(VJ_SS).pdfbody mass indexcathelicidininfertilitylowenstein-jensenmycobacteria growth indicator tube |
| spellingShingle | Swati Gautam Amita Jain Salman Akhtar Apala Priyadarshini Shyam Pyari Jaiswar Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) Journal of Clinical and Diagnostic Research body mass index cathelicidin infertility lowenstein-jensen mycobacteria growth indicator tube |
| title | Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) |
| title_full | Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) |
| title_fullStr | Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) |
| title_full_unstemmed | Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) |
| title_short | Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB) |
| title_sort | serum vitamin d level as a risk factor for female genital tuberculosis fgtb |
| topic | body mass index cathelicidin infertility lowenstein-jensen mycobacteria growth indicator tube |
| url | https://jcdr.net/articles/PDF/10636/30084_CE(RA1)_F(T)PF1-(SY_MJ_PY)_PFA(VJ_SS).pdf |
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